Basic Information

Insect: Drosophila bakoue
Gene Symbol: ewg
Assembly: GCA_008044335.1
Location: VNJL01007197.1:54543-60168[-]

Transcription Factor Domain

TF Family: Nrf1
Domain: Nrf1_DNA-bind domain
PFAM: PF10491
TF Group: Basic Domians group
Description: In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 9.9e-109 2.8e-104 348.1 0.0 1 212 47 257 47 258 0.98

2 2 0.08 2.3e+03 -1.3 0.9 92 117 365 390 332 404 0.63

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	9.9e-109	2.8e-104	348.1	0.0	1	212	47	257	47	258	0.98
2	2	0.08	2.3e+03	-1.3	0.9	92	117	365	390	332	404	0.63

Sequence Information

Coding Sequence: ATGCTGGACGAGGACATCCAGAGTTTGGGctccgatgacgatgacgaggatCTGATTAGCAGCGATGGCAGCCTGTATGAGGGCGATCTCGGCTCTATACCCGTCAACGATGATGTGGCCCATCAGTTGGCCGCTGCCGGACCGGTGGGTGTAGCCGCAGCGGCGGCCATAGCCAGCTCCAAGAAGCGCAAGAGGCCGCACTGCTTCGAAACGAATCCATCGGTGCGAAAGAGGCAACAGAATCGGCTACTCCGCAAGCTCCGTGGCATCATCTACGAGTTCACGGGGCGGGTGGGTAAGCAGGCCGTGGTGCTGGTGGCAACGCCGGGAAAGCCCAACACCAGCTACAAGGTTTTCGGGGCCAAGCCGCTCGAGGATGTGCTGAGGAATCTAAAGAACATCGTCATGGATGAGCTGGACAATGCGCTGGCACAgcaggcgccgccgccgccgcaggaTGATCCGTCGCTGTTCGAGCTGCCGGGCCTCGTTATCGATGGAATACCCACGCCCGTGGAGAAGATGACGCAGGCACAGCTGCGAGCCTTCATCCCGCTGATGCTCAAGTACTCCACCGGCAGGGGGAAGCCCGGCTGGGGCCGTGAGTCGACCCGTCCGCCCTGGTGGCCGAAGGAACTGCCGTGGGCTAATGTACGGATGGATGCACGCTCCGAGGACGACAAGCAGAAGATCAGCTGGACGCATGCCCTGCGCAAGATCGTGATCAACTGCTACAAGTACCATGGCAGGGAGGACCTGCTGCCCACCTTTGCCGACGACGAGGACAAGGTCAATGCTCTCATTTCACAGTCGGgcgacgaggatgaggacatGGAGCTGTCCAATCCGCCGACCATTCACACGGTGACCACCATGACGCCACCGACGGGCAACAGCAATCAACCGCAGCAGGTGAACGTGGTGAAGATCAACAGCGCCGGCACCGTGATCACCACGCACACGGCCCAGAGCAATACGCCCGCTCCGACGATCATCCAGAGTACCAACAACCAGCACGTGACCACAACGGCCACGCTGCCCGCCTCCACAAAGATTGAGATCTGCCAGGCGCCCGccccgcagcaacagcagcagcagcaccagcagcatcatcaccagcaacagcagcaacaccatcaCCAGCAACACCATCAGACCAGCGTACCCAGCACCGTTCACATACAGCCGGTGAGCGGCGGTCAGCCGCAGACCATTCAGCTGACCACGGCCAGTGGCACCGCCACGGCCACAGCGGTGCCGACGACAGCTGCTGCCGTAAGTGCCGCTCAAGCGGcagcggccgccgccgcccaagcAGCCGCCGCCCAGTCGAATGCCCAGCAGACGGTCACTGCCCAGCAGATAGCCAACGCCCAAGTCTGCATCGAGCCCATAACGCTGAGCGACGTTGATTACACCACGCAAACGGTGCTCTCGCAGAATGCCGATGGCACAGTGTCTCTGATCCAGGTGGATCCCAATAATCCCATCATCACGCTGCCGGACGGAACCACCGCCCAGGTGCAGGGTGTTGCCACGcTCCATCAGGGCGAAGGCGGTGCCACCATTCAGACCGTACAGAGTCTCACGGATGTCAATGGCCATGAGAACATGACCGTGGACCTCACCGAGACGCAGGATGGCCAGATATTCATCACCACCGAGGATGGTCAAGGCTATCCCGTGTCGGTCAGCAATGTGATCTCGGTGCCCGTCTCCATGTACCAGTCGGTGATGGCCAACATGCAGACAATTCAGACGAACAGCGATGGCACCGTGTGCCTGGCCCCCATGCAGGTGGAGAACGGCGACCAATTGGAGACCATTACCATGTCACCGGGCATGCACCAAATGATGATCCAAGGCGGTCCCGGCCAGGAGCCGCAGCTGGTGCAGGTGGTTAGCCTCAAGGATGCCACGCTGCTGAGCAAGGCCATGGAGGCCATCAATTCGGGGAATGTCAAGACCGAGGATACGATCATAATGGAACAATAG
Protein Sequence: MLDEDIQSLGSDDDDEDLISSDGSLYEGDLGSIPVNDDVAHQLAAAGPVGVAAAAAIASSKKRKRPHCFETNPSVRKRQQNRLLRKLRGIIYEFTGRVGKQAVVLVATPGKPNTSYKVFGAKPLEDVLRNLKNIVMDELDNALAQQAPPPPQDDPSLFELPGLVIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGRESTRPPWWPKELPWANVRMDARSEDDKQKISWTHALRKIVINCYKYHGREDLLPTFADDEDKVNALISQSGDEDEDMELSNPPTIHTVTTMTPPTGNSNQPQQVNVVKINSAGTVITTHTAQSNTPAPTIIQSTNNQHVTTTATLPASTKIEICQAPAPQQQQQQHQQHHHQQQQQHHHQQHHQTSVPSTVHIQPVSGGQPQTIQLTTASGTATATAVPTTAAAVSAAQAAAAAAAQAAAAQSNAQQTVTAQQIANAQVCIEPITLSDVDYTTQTVLSQNADGTVSLIQVDPNNPIITLPDGTTAQVQGVATLHQGEGGATIQTVQSLTDVNGHENMTVDLTETQDGQIFITTEDGQGYPVSVSNVISVPVSMYQSVMANMQTIQTNSDGTVCLAPMQVENGDQLETITMSPGMHQMMIQGGPGQEPQLVQVVSLKDATLLSKAMEAINSGNVKTEDTIIMEQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00359211;
90% Identity: iTF_00477761; iTF_00604577; iTF_00488454; iTF_00580424; iTF_00359211; iTF_00480621; iTF_00594285; iTF_00491255; iTF_00489119; iTF_00505144; iTF_00593592;
80% Identity: -