Basic Information

Insect: Drosophila austrosaltans
Gene Symbol: topi
Assembly: GCA_035045865.1
Location: JAWNOQ010000194.1:5919277-5921864[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.00013 0.015 16.5 1.0 2 23 244 265 244 265 0.97

2 9 0.75 84 4.6 0.6 2 23 292 313 291 313 0.91

3 9 0.1 12 7.3 0.0 2 23 372 393 371 393 0.95

4 9 0.00025 0.028 15.6 0.5 1 22 440 461 440 464 0.90

5 9 5.2e-07 5.8e-05 24.0 1.9 1 23 522 544 522 544 0.95

6 9 0.00053 0.059 14.5 1.1 1 23 550 575 550 575 0.96

7 9 0.45 51 5.3 1.7 1 23 581 603 581 603 0.88

8 9 3.8e-08 4.3e-06 27.6 0.4 1 23 609 631 609 631 0.99

9 9 0.0018 0.2 12.9 2.0 1 23 637 660 637 660 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.00013	0.015	16.5	1.0	2	23	244	265	244	265	0.97
2	9	0.75	84	4.6	0.6	2	23	292	313	291	313	0.91
3	9	0.1	12	7.3	0.0	2	23	372	393	371	393	0.95
4	9	0.00025	0.028	15.6	0.5	1	22	440	461	440	464	0.90
5	9	5.2e-07	5.8e-05	24.0	1.9	1	23	522	544	522	544	0.95
6	9	0.00053	0.059	14.5	1.1	1	23	550	575	550	575	0.96
7	9	0.45	51	5.3	1.7	1	23	581	603	581	603	0.88
8	9	3.8e-08	4.3e-06	27.6	0.4	1	23	609	631	609	631	0.99
9	9	0.0018	0.2	12.9	2.0	1	23	637	660	637	660	0.96

Sequence Information

Coding Sequence: ATGAGTGGCTCAGATTTGTGGAACCTACAGTCGAATGGGACAGCTGGCGAATATACAGTTGCCGAAATTGAAGTTGAGGATGGAGCACAATTTGTCATAGATGAATTGCAATCGGGTGCTACTGTGCTGGCGGCCAATGAAGGTGATGGTAACGTGGAGCGAGTTTTTGGTCATGAAGAGTTGTCGAGATTTTTTGTAGCGCCACCAAAAGCCAATATCGAAATGCCCACTGAGGTGGTAGTGCAACGCACTTTAGCTGATCCGGCTCTGAAGCAGATTTTGCAGGAAGCAGATGGCAAACCTGGATTTGATCCTGAGGCTGAGCAAATGAAAATCCGCGACTTTTTAGCTGGTGTTAGTAAAGGCAAAATGACGACGGAGGAAAGTGTCTTTCTTGCACCTCGGCCCGGAACATCGTCCAGTGTGGCACCAACGAGTCGCACCATTAAATGCAGTCGCTGCGATATGCCCTGCGATGTGCATTCCTTCAATAAACATGAATGCGAAGGGGAACGCAAACCGGTCGACACTTCAAATGGAAAGCAAGAAAAGCAGCCGGAATCCAAAGTGATGTCAATATCGCCACCGGCTCCATGTAAGCCGGCCAATGAACGCGTCATCTTGGAGAACCAAATACGGTTACGCCGCTACATGAAGGATGAACTTAAATGCGATCTGACAACTGGCACGATCAATACCAGGTCAAAGAAGGCGGTTAAGGGGCCCAATGAGTGTACCATGTGTGAGCGCAAATTCGTACATGCTTCAGGCTTGGTTCGTCACTTAGAGAAGCATGCTCTGGATCTAATTCCTACACATAACATTCAGCCACACGTAATACCCCCACCAGCTCCAGGACTCCATGTCGTTCTCAAGTGCAATACTTGCTTTCGTATCTTTTATAACGTCAAGTTTGCTAATGAACATGTCCTGATTCACTATCCACCACAGCCGAAGCTTAGCGAGCCCAAGGCCACTATTAAGGATACCTTTGATATAGAACAGTTCCTGCTAGAAGGAGAGCAACTACTCGCCTCGTCCAAAGAAATTTCCTACGTTAAATCAAGCCTGGAGAACGATTTATTCGAGACCCTAATTGTGGGCAGCGTCCTGCAGTGCGAGTTTTGTGAATATATTTTTGCGGGAATATCGGAGCTGCTCCTGCATTCGGCCACCCATGTTGCTGAAAGGCGGTTTGAGTGCACCGCCTGTGATCTTACAATGAATACAGCAAAAGAGGCTAGTGTTCACTTTCAGACCGACTGCATTTTTATGCGGGAAGGACTTAAGCTTCTTAACGTCTCACTGAATCGTTATTTTGTGTGCAATGTATGCGAGCAAAAGTTCTCCAATGCGGAACTACTGCAGGAGCATCGATCTAGCACCTATCATTATTTTCCTCGTCTCAGCGAGAATAGTAAACGTCTACTCCTTCCTTGTGAGTTTTgtgaaacaaattttgaatttgctCATGAGATTTTACCACACAACGAGGAGAAGcatttgaataaaaagaaGCGGGAGAAGGAGGCCCGCAATACTGCAACTGGTCGGGTTCGTCAGTATTTGTGTGACATCTGTGGCAAATCTTACACCCAGTCTAGTCATCTTTGGCAACATTTGCGCTTCCATCAGGGTGTCAAGCCGTTTGTTTGTCAGGAGGAGAACTGCGGCAGAAAATTCACCATTCGTCCGGATCTCAATGATCACATTCGCAAATGTCATACTGGAGAGCGGCCCTATCATTGCTTGGTTTGTGGCAAGCGTTTTCTCACGGGATCCGTGTTCTATCAACATCGCTTGATTCATCGCGGGGAGCGGCGCTATGAGTGCGAGGAATGCGGCAAGCGATTCTATCGTGCCGACGCCCTTAAAAACCATCAGCGTATCCATACAGGTGAAAAGCCTTATAGCTGTCTATTCTGCACCAAGACATTTCGCCAGCGTGGTGACCGTGACAAGCATATCCGAGCACGCCATTCCCATCTTGATGCCAATTCGCGCCTCAtgatgcaaatgcaaaaatttcaattggagTCGGCTGCCAAGGCAAAGAGAAACGGCGGTCAACCAGAACGtcctaaaaaggaaaatgatgAATCAGTGGAAGGTGATGAGAATGCTAAGCTTGAAGCCATTGCCAAACTATCGGAGGAACAGGAATTCCTGGCTTGTGTGCCCGGAACAGAGGATTATGGACCTCCTCCCATTTTGGTGGAGAACGCTCCAGTCAGTCAAGAGGATATTATGTACGAGAACCAAATGCagatgcaaatgcaaatgcaaatgcagatGCAGGCACAGGATGTGATTAACACCAACGATAATATCGTAATGTCTATTTTTGATCCAACGCCAGAGCCAAGTCAATCTAGTATTTTAGAAAGCATTCCTTTGCTGCAAAGCAGTGATCATGCCAAAGTAGTGGTGGTCAAAAACAATCCCTCACAGCCAATGTTTTCAGATTCTTATTTGTGA
Protein Sequence: MSGSDLWNLQSNGTAGEYTVAEIEVEDGAQFVIDELQSGATVLAANEGDGNVERVFGHEELSRFFVAPPKANIEMPTEVVVQRTLADPALKQILQEADGKPGFDPEAEQMKIRDFLAGVSKGKMTTEESVFLAPRPGTSSSVAPTSRTIKCSRCDMPCDVHSFNKHECEGERKPVDTSNGKQEKQPESKVMSISPPAPCKPANERVILENQIRLRRYMKDELKCDLTTGTINTRSKKAVKGPNECTMCERKFVHASGLVRHLEKHALDLIPTHNIQPHVIPPPAPGLHVVLKCNTCFRIFYNVKFANEHVLIHYPPQPKLSEPKATIKDTFDIEQFLLEGEQLLASSKEISYVKSSLENDLFETLIVGSVLQCEFCEYIFAGISELLLHSATHVAERRFECTACDLTMNTAKEASVHFQTDCIFMREGLKLLNVSLNRYFVCNVCEQKFSNAELLQEHRSSTYHYFPRLSENSKRLLLPCEFCETNFEFAHEILPHNEEKHLNKKKREKEARNTATGRVRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCGRKFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQKFQLESAAKAKRNGGQPERPKKENDESVEGDENAKLEAIAKLSEEQEFLACVPGTEDYGPPPILVENAPVSQEDIMYENQMQMQMQMQMQMQAQDVINTNDNIVMSIFDPTPEPSQSSILESIPLLQSSDHAKVVVVKNNPSQPMFSDSYL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00600541;
90% Identity: iTF_00600541;
80% Identity: -