Basic Information

Insect: Drosophila austrosaltans
Gene Symbol: wek
Assembly: GCA_035045865.1
Location: JAWNOQ010000180.1:2328721-2330637[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 1.7e-05 0.0019 19.2 1.9 1 23 277 300 277 300 0.98

2 8 3.6e-05 0.0041 18.2 8.0 1 23 310 332 310 332 0.99

3 8 0.00052 0.058 14.6 0.0 2 23 342 364 342 364 0.92

4 8 2.3e-05 0.0026 18.8 0.1 1 23 370 392 370 392 0.98

5 8 0.00012 0.014 16.5 3.4 1 23 398 420 398 420 0.95

6 8 5.4e-05 0.006 17.7 0.7 1 23 424 446 424 446 0.97

7 8 9e-05 0.01 17.0 2.4 2 23 453 474 452 474 0.95

8 8 0.012 1.4 10.3 3.1 1 23 480 503 480 503 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	1.7e-05	0.0019	19.2	1.9	1	23	277	300	277	300	0.98
2	8	3.6e-05	0.0041	18.2	8.0	1	23	310	332	310	332	0.99
3	8	0.00052	0.058	14.6	0.0	2	23	342	364	342	364	0.92
4	8	2.3e-05	0.0026	18.8	0.1	1	23	370	392	370	392	0.98
5	8	0.00012	0.014	16.5	3.4	1	23	398	420	398	420	0.95
6	8	5.4e-05	0.006	17.7	0.7	1	23	424	446	424	446	0.97
7	8	9e-05	0.01	17.0	2.4	2	23	453	474	452	474	0.95
8	8	0.012	1.4	10.3	3.1	1	23	480	503	480	503	0.98

Sequence Information

Coding Sequence: ATGGAAAAGGTGTTGCCCAAAGGAAAGATTAAAATGGAGAGCGACTGGCATCAGTGGTGTCGTCTTTGTGCTGGCCATTATCCGGACAATATAAATCTCTCTTCGATTGATCCAACAGGCTTGGTCATGGCAATTGGCAAATACTTTTGGGTAGACATTAAAGTGGATGATGGATTAAGTCAGTGTTTATGCCGAGAATGTCAAAGGCTGGTGGAATATCTAATCAAGTTTTCGGAGCAAGTTCATCGAGTGCAGAGAATGTATGGAAAACTGCAGTGTGCCAACCCTGACAGCAATTTTGATAATGATAATATACGCAAGGAGTGTGGCGATTGGGTTCACATGATACCCTGTCTAAGGAGTCCCCAAAATCCAGATACAGCAATAGTTACAGAAATAGAGGAGATGGATGATGCAAATGTGGAAGATTTCTTAATAATTGAAGAGGAGGCGGAGGAGGCTGAAATAGGGGGGGAATTGAAAGTAAATGAACAAGAAGTTGCAAATCATGAGCACATAGGAGAAGAGCAGGAGGAATACCAGGAGCAGTATGAAGAAGACCAGCAGCAATACGATGAAGTTCAGGTACAGGTCGAAGAAGTCCACGATCAGAACGAAGAAGACCTAGAGCAGGAGGTAGAAGATCAGGATGACGAGCTGGAAAAGTATGATATTGAAGTGCAGAATATAAAAGACCATATAACAACAGaatttgatgatgatgaaactGTAGACGAGGATAATACATCAAATTCGTTTCAACTTGAACTAAAATCAAACTCCAGCTTACAAACACTAGATGAAGATGTTGGGATAAAGGCCACGGAATACAAATGTAAACTTTGCCCCAAGATCTATAAGAAACCTACGACTTTTAAACAACACATGGCCACCACTCACGGTTCCTACTTCAAACATATGCCGAACTATCAATGTCATCATTGTGATAGCACATTTACCACAATCCATCAATTGACTGCCCACTATCGCACCCACATGACAATCAATGAGAAGAAGTCCAATTCTTGTCCAATGTGTGCCAAATTATTTACCACAGCTGGAGCTCTTAATAGACATATAGCTGgtacacataaaaaaataacgcCCTATGTCTGTGATATATGTGGCAAGGCGGTCAAAACTCTTGGTAGCCTTAAGGATCACAAGCTGGTGCACACAGATGCTTGCCCGTTTGAGTGTGATGTGTGTCATCGacgatttaaaaacaaatcaagACTCCGAGTTCATTCAGATTCCCATACCGAGGGTTATGACTGTGATATTTGTGGCATGACACTCAAAACCCGACGCACTCTAAACACACACCGTCAAGTGCATTCGGATGAGAGGAAATGCAAATGTGAGGTTTGTGGTGCAACCTTTAAACGTACCAAAACCCTGAAATCTCATCTCATTCTGCATACGGGCATACGACCGTACAAATGCAATTTCTGTGGTGCGGCATTTGCCAATGGTTCCAATTGCCGGATGCATAAGCGGAAAAAGCATCCCAAAGAACTGGCCGAAGAGGAATCAAGGCGTGTGATTCGCTCCACTCGATTGCCCTTAATTGATGACCTTAATGAGGCATCGAAGCGTATCAAAACACCGGCCAAAAAGCCATCAGTACgaacgaaaacaacaaaacccaACAGTATTAATCCATCAAGCAGGCTGGAAGAAGATGAAGACGATATTATCGATGATTTGGTGGGTGAAATgtag
Protein Sequence: MEKVLPKGKIKMESDWHQWCRLCAGHYPDNINLSSIDPTGLVMAIGKYFWVDIKVDDGLSQCLCRECQRLVEYLIKFSEQVHRVQRMYGKLQCANPDSNFDNDNIRKECGDWVHMIPCLRSPQNPDTAIVTEIEEMDDANVEDFLIIEEEAEEAEIGGELKVNEQEVANHEHIGEEQEEYQEQYEEDQQQYDEVQVQVEEVHDQNEEDLEQEVEDQDDELEKYDIEVQNIKDHITTEFDDDETVDEDNTSNSFQLELKSNSSLQTLDEDVGIKATEYKCKLCPKIYKKPTTFKQHMATTHGSYFKHMPNYQCHHCDSTFTTIHQLTAHYRTHMTINEKKSNSCPMCAKLFTTAGALNRHIAGTHKKITPYVCDICGKAVKTLGSLKDHKLVHTDACPFECDVCHRRFKNKSRLRVHSDSHTEGYDCDICGMTLKTRRTLNTHRQVHSDERKCKCEVCGATFKRTKTLKSHLILHTGIRPYKCNFCGAAFANGSNCRMHKRKKHPKELAEEESRRVIRSTRLPLIDDLNEASKRIKTPAKKPSVRTKTTKPNSINPSSRLEEDEDDIIDDLVGEM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00591149; iTF_00577972;
90% Identity: iTF_00591149; iTF_00577972;
80% Identity: -