Basic Information

Insect: Drosophila atripex
Gene Symbol: ZEB2
Assembly: GCA_035045925.1
Location: JAWNOP010000022.1:7449831-7451867[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 0.15 12 6.6 0.2 1 21 324 344 324 345 0.95

2 10 1.1e-06 8.3e-05 22.8 0.3 1 23 353 375 353 375 0.99

3 10 0.00031 0.024 15.1 0.3 1 23 378 401 378 401 0.93

4 10 6.5e-07 5.1e-05 23.5 0.8 2 23 408 429 407 429 0.98

5 10 3.1e-08 2.4e-06 27.7 1.0 1 23 435 457 435 457 0.98

6 10 4.6e-06 0.00035 20.9 0.8 1 23 463 485 463 485 0.99

7 10 0.0011 0.085 13.4 3.1 3 23 493 513 491 513 0.98

8 10 0.00093 0.072 13.6 0.3 1 23 519 541 519 541 0.98

9 10 8.7e-05 0.0067 16.8 3.7 1 23 547 569 547 569 0.99

10 10 0.0027 0.21 12.2 0.1 1 23 575 597 575 597 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	0.15	12	6.6	0.2	1	21	324	344	324	345	0.95
2	10	1.1e-06	8.3e-05	22.8	0.3	1	23	353	375	353	375	0.99
3	10	0.00031	0.024	15.1	0.3	1	23	378	401	378	401	0.93
4	10	6.5e-07	5.1e-05	23.5	0.8	2	23	408	429	407	429	0.98
5	10	3.1e-08	2.4e-06	27.7	1.0	1	23	435	457	435	457	0.98
6	10	4.6e-06	0.00035	20.9	0.8	1	23	463	485	463	485	0.99
7	10	0.0011	0.085	13.4	3.1	3	23	493	513	491	513	0.98
8	10	0.00093	0.072	13.6	0.3	1	23	519	541	519	541	0.98
9	10	8.7e-05	0.0067	16.8	3.7	1	23	547	569	547	569	0.99
10	10	0.0027	0.21	12.2	0.1	1	23	575	597	575	597	0.96

Sequence Information

Coding Sequence: ATGGATGTTGACAAAATTTGCCTAACATGCCTCAGCTCCTCAGGTCCTTTGGTGTCCATTTACGACGGGGGATCAGGTAGCTGTCTGGCAGACATGCTGCGTGAATTCACAAAAACAAAGCCTCGAAAGAACGATAACTTGCCGGAGAGGGTGTGCCTAGGCTGCTTGAGCGAGATAAACCACTGCTATACGTTTAAGATCAAGTGCGAAAACTCCAGTCGGACCCTGAGGCAACTGTTACCCAACGCATTGCCTGAGGAGCCCGACCAGAAGGTGTCCGCTAAAGAGGCAGTAGACACCGCGGAACAGGGTGTTCAAACGATAGACTGGACACCCAGGCAATGCACCTCGTCCGTTCAAACGGACGCAGTGTCCACCGCGAATGCCGAACAGAATACCAGTCTGGAGAAGCCGGATTTGCCAGAAGATCTGGAGGAGGATGAAGGAGAGGTTTTCGACTATGAACTAACTGATGCTCCAGAGGAGAAGACACAGAACATTATTCTTCACTTGCAGGACAGCTTAAAGAACGAGAAAGAAGTGGTGTTTACCCAAACTGATGTAATTTATGATGGCGACGACAATGAACTGGAGCAGCAGATTCGAGAGTGCAACATGGCCATATTCGAGACGGCTGACGGTGAGGCGGAGATTGTGGAACTGCCCTCTCCCCAGGTAACCACCAGAAATAGCGCGGCTAAACTTCAAATGCAGCAGCAGAAACCAGTCAGGGAAACGTCAGAAAGAAACGTCAAATCAGAAGCTAAAGGCGAGGAACCGCCACCGACGGGTAAGAGGACATCACGCCGCAGACCAGCACCTCAGCCGGAAGAACAAGTAAAGCCACCAATAGCAACAGCTAGTCCAGCAAAACAACTCCGTTTGGGTAGCACCCGGAAATCCCTGAATTCGGCGGTCTCCGTTACCATCCCGGGAGCAACCGCAGCAAGCTTAACAGCCGAACTGAAGTACCATTGCGATCGTTGCAATGCGGGTTTTGCGCTGGAAAAGTCGCTGATCATACACAAGCGCCAGAAGGGCTGCACCAACCGCAACTTCAAGTGTAATGAGTGCGAAAGGGTCTTCGTATCGCCGGAGCACTTAGCTGAGCATCAGGCTACTCATGGAACACATACTTGCGCGGAATGCGGGCTGCAGTTCGAGTCCAAAGAGCAGTTGGGCAAACACATGGTGCAGGGTCACAAGCGAAACCTGCGTAATCAGTGCAACATTTGCCAAAAGGTCTTTACGATGCTTTCCACCTTACGTGACCACATGCGCATCCATACCGGCGAGAAGCCGTTCGTTTGCAATATCTGCGGAAAGAGCTTCACCCAGAACGCCAACTTGAGGCAGCACAAACTGCGCCACTCGGAGACCAAGAGCTTTAAATGTGACCTGTGCCCGCACTCGTTCGTCACCAAGGCGGAGTTGGCTTCTCATGAACGCACCCACACTGGTGATAAGCCCTTTGGGTGCGATGTGTGCCAGGCGAAGTTCACGACCAGTTGCTCTCTGGCCAAGCACAAAAGAAAACACACTGGGGAGCGACCCTATGCCTGCGACCTTTGTCCAATGCGATTCACGGCCCTGAATGTCCTTAAGAATCACAGAAGGACGCACACTGGGGAGCGACCGTACGTGTGTCCCTTCTGCTCCAAGACCTTCACGCAAAGAGGCGATTGCCAAATGCACCAGCGCACCCATCAGGGCGACCGTATTTACATCTGTCCCGTGTGCAGCGAAGAGTTTAAATCTATGCCGGATATGCGATCCCATTTGTCGGAACACGAACAGCATGACAAGCGACTGGTGCATTTCACCCTGCTGAGCAACAAGGAGAATGGCAGTGGAAGCGGTGGTATCGAGGAAGACCTAAATGAAATGGCAGAGACGGCACTAATGCtataa
Protein Sequence: MDVDKICLTCLSSSGPLVSIYDGGSGSCLADMLREFTKTKPRKNDNLPERVCLGCLSEINHCYTFKIKCENSSRTLRQLLPNALPEEPDQKVSAKEAVDTAEQGVQTIDWTPRQCTSSVQTDAVSTANAEQNTSLEKPDLPEDLEEDEGEVFDYELTDAPEEKTQNIILHLQDSLKNEKEVVFTQTDVIYDGDDNELEQQIRECNMAIFETADGEAEIVELPSPQVTTRNSAAKLQMQQQKPVRETSERNVKSEAKGEEPPPTGKRTSRRRPAPQPEEQVKPPIATASPAKQLRLGSTRKSLNSAVSVTIPGATAASLTAELKYHCDRCNAGFALEKSLIIHKRQKGCTNRNFKCNECERVFVSPEHLAEHQATHGTHTCAECGLQFESKEQLGKHMVQGHKRNLRNQCNICQKVFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCDLCPHSFVTKAELASHERTHTGDKPFGCDVCQAKFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGDRIYICPVCSEEFKSMPDMRSHLSEHEQHDKRLVHFTLLSNKENGSGSGGIEEDLNEMAETALML

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00476066;
90% Identity: iTF_00580112;
80% Identity: -