Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 8.5e-06 0.00048 19.9 0.6 2 22 164 184 163 184 0.95

2 6 0.025 1.4 9.0 0.1 2 23 194 215 194 215 0.96

3 6 1.9e-05 0.0011 18.8 3.3 2 23 222 243 221 243 0.96

4 6 4.6e-05 0.0026 17.6 0.7 1 23 249 271 249 271 0.98

5 6 0.00018 0.0099 15.7 6.4 2 23 279 300 278 300 0.96

6 6 7e-08 3.9e-06 26.4 1.5 1 23 307 329 307 329 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	8.5e-06	0.00048	19.9	0.6	2	22	164	184	163	184	0.95
2	6	0.025	1.4	9.0	0.1	2	23	194	215	194	215	0.96
3	6	1.9e-05	0.0011	18.8	3.3	2	23	222	243	221	243	0.96
4	6	4.6e-05	0.0026	17.6	0.7	1	23	249	271	249	271	0.98
5	6	0.00018	0.0099	15.7	6.4	2	23	279	300	278	300	0.96
6	6	7e-08	3.9e-06	26.4	1.5	1	23	307	329	307	329	0.99

Coding Sequence: ATGAGCACAGCACGGccgttttgtttcgtttgtgGCAAGGTGAAGTCTGTTGGCGTCTTTCAGCTCATTGAAGGATGCATCGTCCCGGGCACATTTAAGCCCATTAAAGACATACTGAAATACTTTGAAAAGGTAATTAATCAACGCTTGGATCTGACTCCCACGTCGGCTGCTTGCAATGATTGCCTCGAATATCTCTTCAATTACGACCGGCTCGTTCGGAACCTGAGCCAAGTGCAGCGACAAATTGCGAACTCTTTGCTCAGTTGTCGTAAAAAGAAACCGATATGCTTACAGCCCAAGAAGGATACAGTTAAACCTAAAATACCGGAAATGCGATCAAGAATCGTGGAAAATGAGTCGCCACAGAAGAGCTACAAGCGGGAAGCAGATGAATTTCTGGATTTGGAAGAGTCAAATCGAGAGTCCCCATTTACCGAGAGCGAGGAGAGCATGGACGATTCAGATGGGGATGATAACCTAGATATTCCATGTCACATATGCGGCGAACTTTTCTCGAATCAGGACTGTCTCGAAAAGCACATCAAAACGGACAATTGTCAAAAGAACGAATTGGCCACCTGCAATATATGTGGCATTAAAGTGAAAAACGACGAAGTTCTCGATCTGCACATGAATCTTCATGAGGGCAAAACGGAACTGGAATGCCGGTACTGCTCGAAAAAGTTCTCACATAAACGGAACGTCCTGCGTCACATGGAGGTACATTGGGACAAGAAGAAATATCAGTGCGAAAAGTGTGGCGAACGCTTCTCACTGTCCTGGCTAATGTACAATCATCTAATGCGGCACGATGCCGAGGAACATGCCCTGATCTGTGATGTTTGTCATCAGCAATTCAAAACGAAACGCACCTACAAACATCACCTGCGTACTCATCAAACTGATCGTCCGCGCTACCAGTGCACAGACTGCGAAAAGTCCTTCGTCGATAAATACACTTTAAAGGTGCACAAACGCGTCCATATGCCAGCTGAGTCAACAATGTCGGCCACATAA
Protein Sequence: MSTARPFCFVCGKVKSVGVFQLIEGCIVPGTFKPIKDILKYFEKVINQRLDLTPTSAACNDCLEYLFNYDRLVRNLSQVQRQIANSLLSCRKKKPICLQPKKDTVKPKIPEMRSRIVENESPQKSYKREADEFLDLEESNRESPFTESEESMDDSDGDDNLDIPCHICGELFSNQDCLEKHIKTDNCQKNELATCNICGIKVKNDEVLDLHMNLHEGKTELECRYCSKKFSHKRNVLRHMEVHWDKKKYQCEKCGERFSLSWLMYNHLMRHDAEEHALICDVCHQQFKTKRTYKHHLRTHQTDRPRYQCTDCEKSFVDKYTLKVHKRVHMPAESTMSAT

Sequence clustering based on sequence similarity using MMseqs2