Dara006256.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila arawakana
Gene Symbol
run
Assembly
GCA_018151165.1
Location
JAECWX010000002.1:11345850-11373013[+]

Transcription Factor Domain

TF Family
Runt
Domain
Runt domain
PFAM
PF00853
TF Group
Beta-Scaffold Factors
Description
The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.3e-65 9e-62 206.2 0.1 14 129 7 122 3 122 0.96

Sequence Information

Coding Sequence
ATGTATTTTCATGTCATAGTTGCGGGTAGCTCATGGCCGGTCTGCACCACGCTCCCCACCCATTGGCGGTCCAATAAAACGCTGCCCATTGCTTTCAAGGTGCTGGCACTCGGTGAGGTCATGGATGGCACCATTGTGACCATACGTGCTGGCAACGATGAGAACTTTTGTGGTGAACTACGTAACTGCACCGCCGTGATGAAGAACCAGGTAGCGAAATTTAATGACCTGCGATTTGTAGGACGCAGCGGCAGAGGCAAAAGCTTTACGCTTACAATTGTCATCTCAACAAATCCGATACAGATTGCCACCTACACGAAGGCCATCAAGGTGACTGTCGATGGTCCACGAGAGCCCCGTTCGAAGGTGCGTCACCAGGGCTTTCATCCGTTCGCCTTTGGCCCCCAACGCTTTGGCCCAGATCCACTTATGGCCGGATTACCCTTTAAGTTGCCAGGTTTCGCCCATCACTTGGTGGGCATGCACAGTCACCTGCACGCACCCGATTGGCGAGCTCACATGGCGCTGGGTGGACGACCCGGTTTTCCGGCAGGACCCTTCTTTGCACATCATCACGGAGGCGGCTTTCCCACCGCTGCGGCGAGTGGACTGCGCAGTCTAAATGACAATCAGCAGCAATTGGCGACAGTGGGAGCAGCACATAGTACCACCAGTCCGGAGGGTTCGCCGACAACTACAACGAGTGCGACACTGAGTGCGTTCGTACAGCCACCGGCTTGCAATACCAGCGTGGACAGCTCACCGCCTCTGACCTTGAGTCTGACCAGTTTGCAGCATCACGACAATAACAACAACAATAGCAGCAGCAATATTGATGCAGGATTCGAGAGTGATAGCATTTCGGTGACGGGATCGCCAAGGAAAAGTATTAGCTCCTTGACCCATGACGAGGAGGAGCCCGATCCGGAGGCAGGACGTAGTCGTAGTCCTACAGTGCTCAGTGCCGATGCCAGCAGTGTGGCAACCCTGGCAGAACCGACACCTGGCAACGGCGGTGCCTTTACAGCACTGATACAGCGCAGCAAGAATCCTACGGAATTGTTTGGCGGATTTGCAGCTGCAGGAGCGGGACACTTTGCTCCTACTGCGCATAGTTTTAATCCTGCATTGGCAGCCCAGCTATTCCTGCAGAGTCCACTGTTGCCTCAGTCGAGTCAGTGGCTCTACACGCAGCTCTACGGCAGCTACAGTGAACTGCCCTGGTTGCGTAGTGCAGCGGCTGCAGCAGCAGCAAGCACAGCTCCACAGCAACAGCAGCCACAGGAGCCTCCAGTGCATCCGACGCTAACCACAGACACCGATGGGGTTAATCTTATCAAGCGTTGTGTGACGCTGATTACGCATAATCCGCCGGATGCCGAAAATGCCAATCCGAATGCGTCACCGCCAGTCAGCTCCACACGACGTTCGCCCTCGCCCGTGGAGACTATTGATCTTGATGATGTCAGCACTACGTCGAGATCGGCCAGTGGCTCGAGCGGAGCTGGCGGTCCGATACGTACACGTACGCCCAAACCGGCGGCGGATGTATGGCGTCCCTACTAG
Protein Sequence
MYFHVIVAGSSWPVCTTLPTHWRSNKTLPIAFKVLALGEVMDGTIVTIRAGNDENFCGELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTIVISTNPIQIATYTKAIKVTVDGPREPRSKVRHQGFHPFAFGPQRFGPDPLMAGLPFKLPGFAHHLVGMHSHLHAPDWRAHMALGGRPGFPAGPFFAHHHGGGFPTAAASGLRSLNDNQQQLATVGAAHSTTSPEGSPTTTTSATLSAFVQPPACNTSVDSSPPLTLSLTSLQHHDNNNNNSSSNIDAGFESDSISVTGSPRKSISSLTHDEEEPDPEAGRSRSPTVLSADASSVATLAEPTPGNGGAFTALIQRSKNPTELFGGFAAAGAGHFAPTAHSFNPALAAQLFLQSPLLPQSSQWLYTQLYGSYSELPWLRSAAAAAAASTAPQQQQPQEPPVHPTLTTDTDGVNLIKRCVTLITHNPPDAENANPNASPPVSSTRRSPSPVETIDLDDVSTTSRSASGSSGAGGPIRTRTPKPAADVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00521124;
90% Identity
iTF_00568749; iTF_00470641; iTF_00537285; iTF_00585738; iTF_00608215; iTF_00610423; iTF_00490557; iTF_00616683; iTF_00562957; iTF_00474992; iTF_00526353;
80% Identity
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