Basic Information

Insect: Drosophila anomelani
Gene Symbol: topi
Assembly: GCA_035045905.1
Location: JAWNOO010000032.1:18620388-18622303[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 8.3 7.4e+02 1.2 0.1 12 23 39 50 36 50 0.89

2 8 0.0035 0.32 11.8 0.5 2 23 363 385 362 385 0.94

3 8 0.0046 0.41 11.5 6.8 1 23 393 416 393 416 0.97

4 8 3.9e-06 0.00035 21.1 0.8 1 23 421 443 421 443 0.97

5 8 2.3e-05 0.002 18.7 0.6 1 23 452 475 452 475 0.91

6 8 0.0015 0.14 13.0 1.7 1 23 481 503 481 503 0.97

7 8 1.9e-05 0.0017 19.0 1.2 2 23 510 531 509 531 0.96

8 8 0.00045 0.04 14.7 0.7 2 23 537 559 536 559 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	8.3	7.4e+02	1.2	0.1	12	23	39	50	36	50	0.89
2	8	0.0035	0.32	11.8	0.5	2	23	363	385	362	385	0.94
3	8	0.0046	0.41	11.5	6.8	1	23	393	416	393	416	0.97
4	8	3.9e-06	0.00035	21.1	0.8	1	23	421	443	421	443	0.97
5	8	2.3e-05	0.002	18.7	0.6	1	23	452	475	452	475	0.91
6	8	0.0015	0.14	13.0	1.7	1	23	481	503	481	503	0.97
7	8	1.9e-05	0.0017	19.0	1.2	2	23	510	531	509	531	0.96
8	8	0.00045	0.04	14.7	0.7	2	23	537	559	536	559	0.97

Sequence Information

Coding Sequence: ATGATTTGCGCGAATCTTTTGGCGTGGAACAACTACGAGCACTTTACGCTAGCCTGTACGGGTTCCGCTGGCGAAGATGATGACAGCCCCTGTCCCATGGAGATGGAGCTGGAGCGGTGGCGGGAGTTTATCCAGCACATAAGAGACCACCAACGAACGGTTGCTGAAGAGGAAGATGGAGAGAAAGACGGGTTCTGTGACAGCGATATAGGCGAGCTGAAGCAGGTGGCGGAGGAGGATTGCCTGGCCGAGGACATGTTCGTGGATCTGCCCGTGTCCTCAGAACCAGATTCTGATAGCGAAGCGAGAGATGGAGATGTGGATGATGCCAACATGACGCTTGACAGCGAGCAGGGAGCCACAGATTTTAGCCCTTTGTCAAAATTCAATCCCACGTTTTATCGGCGCAGTCCAAGAATTACACGCTTCATTGAACTGTACCAGCAAAAACCCTGCCTCTGGGATCCAGCGGATGAGGCGTACAAGGACAAAGAGAAGCGCACGGCTGCCTACAAGGAGTTACTAGAGCAGCTAAAGACCTCGGTCAACCTCCATCTCACTTCTTACAAGCTGAAGAAGTGCATCTCGAGCTTGCACTCCCAATATGCGTCAATTACGCGCCAGAAGAAGACCCAAAAGTTGACCCAGGTTCCGCTGCACTACCACGCCAAGTATACCTTCTTAGCCAAGTGTGGAGATCCCGCAGAGGCCGAGACCGATGATGACGAGGGCTGTGCCAAGATCAAGCTAGTGTTTACGGAGGAGAACCGGCTGACCAGCCTGTTCATCGATCTGTACGAAAAATTTCCGCATCTCTACGATCCAGCGCACAAACACTTCTCGAACCTGAGCGAACGTAAGTCTGCCATCTTGGAGATGACGGATTTGCTGAGCTCTGAAATTTCGGGATTGAGCCTGCACACGCACTACGAGGTATACGACAGTATTCAGAGCCTGCGGCAATGGTATTCGCGTCGGATTAAGACCCTTACCGATGTGCAGTCCGTTGGCCTGTCCGTGGCCGAGAAGCGGTACATTGAGCGCTGCAGGGCATTCATGCCCACGAAGACGTTCCGCCAGAAGCTGAAGTGCGAAGCGTGCGAGCAGGCCTTTAGCACAGATCACGCCCTGCAGGCGCACCAGTTTCGGGACCACAAGATGGGCGACGGCGGCTGGTTCAGGTGCACGGTGTGCGAGCTGAACTTTGACCGCCGATGCCACCTGCATCAGCACATACAGCGGGTGCACATGAGCAAGGCGTTCGCCTGCGACCTTTGCGACCGGAGCTTCGCCTTCAACAACCAGCTAACGGCTCACAAACGCACCCATGACGAGCAGCATGTCGCGAAGCCGTTTGTCTGCGAGttctgcggcaaatcgttcaAGCAGAAAATCCAAATGACCACACACGTGACGGCGGTGCATACGAAAATCCGCGCCTTTAAGTGCACCATGTGTACCAAGGACTTTCTCACCAAGCGCGATCTCAAGGATCACGTGAAGGCGCACCTGAACATCCGCGACAAGGTGTGCGAAATCTGCCAGAAGACATTCACCAACGCAAATGCGTTGGTCAAGCATCGCCACATTCACAAGGAAAAGACGCTACAGTGCTCCCTGTGCACCACACGCTTCTCGGAGCGCGTCAGCTTGGGCGTTCATATGCGACGCACGCACAAGATCATCAAGAGCACGCAGAAAGTGGCGGAGCCAGCGGGCGAAGCCCTCTTTTCAGCCACATTCCCTCAGACACAAGGCAATACATCCAGCGAATAA
Protein Sequence: MICANLLAWNNYEHFTLACTGSAGEDDDSPCPMEMELERWREFIQHIRDHQRTVAEEEDGEKDGFCDSDIGELKQVAEEDCLAEDMFVDLPVSSEPDSDSEARDGDVDDANMTLDSEQGATDFSPLSKFNPTFYRRSPRITRFIELYQQKPCLWDPADEAYKDKEKRTAAYKELLEQLKTSVNLHLTSYKLKKCISSLHSQYASITRQKKTQKLTQVPLHYHAKYTFLAKCGDPAEAETDDDEGCAKIKLVFTEENRLTSLFIDLYEKFPHLYDPAHKHFSNLSERKSAILEMTDLLSSEISGLSLHTHYEVYDSIQSLRQWYSRRIKTLTDVQSVGLSVAEKRYIERCRAFMPTKTFRQKLKCEACEQAFSTDHALQAHQFRDHKMGDGGWFRCTVCELNFDRRCHLHQHIQRVHMSKAFACDLCDRSFAFNNQLTAHKRTHDEQHVAKPFVCEFCGKSFKQKIQMTTHVTAVHTKIRAFKCTMCTKDFLTKRDLKDHVKAHLNIRDKVCEICQKTFTNANALVKHRHIHKEKTLQCSLCTTRFSERVSLGVHMRRTHKIIKSTQKVAEPAGEALFSATFPQTQGNTSSE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00606549;
90% Identity: iTF_00613010;
80% Identity: -