Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 1.9e-06 0.00017 22.1 2.3 1 23 74 96 74 96 0.98

2 6 1.4e-05 0.0012 19.4 0.8 1 23 102 124 102 124 0.95

3 6 1.5e-06 0.00013 22.5 1.0 1 23 130 152 130 152 0.98

4 6 7.9e-06 0.0007 20.2 1.7 1 23 203 225 203 225 0.98

5 6 6.6e-06 0.00059 20.4 0.4 1 23 231 255 231 255 0.90

6 6 0.00013 0.011 16.4 0.3 1 23 261 283 261 283 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	1.9e-06	0.00017	22.1	2.3	1	23	74	96	74	96	0.98
2	6	1.4e-05	0.0012	19.4	0.8	1	23	102	124	102	124	0.95
3	6	1.5e-06	0.00013	22.5	1.0	1	23	130	152	130	152	0.98
4	6	7.9e-06	0.0007	20.2	1.7	1	23	203	225	203	225	0.98
5	6	6.6e-06	0.00059	20.4	0.4	1	23	231	255	231	255	0.90
6	6	0.00013	0.011	16.4	0.3	1	23	261	283	261	283	0.97

Coding Sequence: ATGGGAGCGGAGAATCCCCAAGTGATGCCCCTGGAGAGTGAGAGCAACAGCTATGGCGTAAGCCTGGAGGATCTGCAGCTGTTTGCCCAGCTGGAAGAAAATCTCAGCGGAAAGTTGGAGCTGGATCTGCTGGAGCTGGTAACTGCTCGGGATAATTCGCCAAAGCCTTTGCCACAGCCATTAAAGCGTTCCAGAGCGACCACCAAAGCATCCAGCGGGCACACCTGTGAGACCTGCGGAAGACGCTTCTCGGAGGCCTACAACCTGCGCATCCACAAGATGACCCACACGGACGAGAAGCCGCATATTTGCAGCGATTGCGGCAAGGGCTTCCGGCAGCTGAATAAGCTGCGCATCCATGCCGTCACCCACACAGAGGAACGGCCGCACAAGTGCGATATTTGCGGCAAGGGATTTCGCTATGCCAACTACTTGGCTGTCCATCGACGGCTGCATACGGGCGAGAAACCATATGCGTGTCTGGTCAAGAGCTGTTCGTTGTCCTTTCACTCCATTCATGCCCGGCGGATCCACCAGAAACTGCAACATGCTGGGGATCTTGAGCTGCTGCCGCAGGAAGACCAGATCTTCACAGAGATCTCCACATTCACGTGTCCCGTGTGCGGGCGTGTCCTCACCGACCAGTGCTACCTGAGCACCCATCTCAAGCGTCACTACAACCAGCGGGACTTTGCCTGTGGCCAGCCGGAGTGCGGCAAAAGCTTCTTCAGCGCCTCGGAGTTGAAGCATCACCAGATAGCCCATAGCCAGCAGCGTCCCTTTGCCTGTGCGCTGTGTCCAGCGCGCTTCCTGCGCAAATCCAATCTCAAGCAGCATCTCAAGGTGCACGAGAGGAATTAG
Protein Sequence: MGAENPQVMPLESESNSYGVSLEDLQLFAQLEENLSGKLELDLLELVTARDNSPKPLPQPLKRSRATTKASSGHTCETCGRRFSEAYNLRIHKMTHTDEKPHICSDCGKGFRQLNKLRIHAVTHTEERPHKCDICGKGFRYANYLAVHRRLHTGEKPYACLVKSCSLSFHSIHARRIHQKLQHAGDLELLPQEDQIFTEISTFTCPVCGRVLTDQCYLSTHLKRHYNQRDFACGQPECGKSFFSASELKHHQIAHSQQRPFACALCPARFLRKSNLKQHLKVHERN

Sequence clustering based on sequence similarity using MMseqs2