Basic Information

Insect: Drosophila anomalata
Gene Symbol: ZEB2
Assembly: GCA_035046425.1
Location: JAWNNY010000846.1:496263-508063[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 7.6 6.5e+02 1.3 2.3 3 23 285 307 283 307 0.90

2 15 1.2 1e+02 3.8 1.8 3 21 449 467 447 471 0.91

3 15 1 85 4.1 1.1 2 23 493 515 492 515 0.93

4 15 1.5 1.3e+02 3.6 3.0 1 23 532 555 532 556 0.94

5 15 0.49 42 5.1 0.2 1 21 560 580 560 584 0.90

6 15 0.0033 0.28 11.9 0.2 2 23 629 651 628 651 0.92

7 15 0.034 2.9 8.7 0.2 1 21 656 676 656 677 0.94

8 15 3.9 3.4e+02 2.2 2.4 1 23 700 722 700 722 0.93

9 15 0.00081 0.069 13.8 4.3 2 23 735 755 734 755 0.97

10 15 4.9e-06 0.00042 20.8 1.1 1 23 761 784 761 784 0.97

11 15 0.00039 0.034 14.8 0.4 1 23 808 830 808 830 0.98

12 15 1.9 1.6e+02 3.2 0.3 1 23 838 862 838 862 0.92

13 15 0.16 13 6.6 3.2 1 23 867 892 867 892 0.96

14 15 0.12 9.9 7.0 2.4 1 23 902 924 902 924 0.97

15 15 0.00083 0.071 13.8 3.1 1 20 930 949 930 951 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	7.6	6.5e+02	1.3	2.3	3	23	285	307	283	307	0.90
2	15	1.2	1e+02	3.8	1.8	3	21	449	467	447	471	0.91
3	15	1	85	4.1	1.1	2	23	493	515	492	515	0.93
4	15	1.5	1.3e+02	3.6	3.0	1	23	532	555	532	556	0.94
5	15	0.49	42	5.1	0.2	1	21	560	580	560	584	0.90
6	15	0.0033	0.28	11.9	0.2	2	23	629	651	628	651	0.92
7	15	0.034	2.9	8.7	0.2	1	21	656	676	656	677	0.94
8	15	3.9	3.4e+02	2.2	2.4	1	23	700	722	700	722	0.93
9	15	0.00081	0.069	13.8	4.3	2	23	735	755	734	755	0.97
10	15	4.9e-06	0.00042	20.8	1.1	1	23	761	784	761	784	0.97
11	15	0.00039	0.034	14.8	0.4	1	23	808	830	808	830	0.98
12	15	1.9	1.6e+02	3.2	0.3	1	23	838	862	838	862	0.92
13	15	0.16	13	6.6	3.2	1	23	867	892	867	892	0.96
14	15	0.12	9.9	7.0	2.4	1	23	902	924	902	924	0.97
15	15	0.00083	0.071	13.8	3.1	1	20	930	949	930	951	0.95

Sequence Information

Coding Sequence: ATGAATCCAGACGACTTGGAGGACACCCATTTGTGTATAAAATGCAATGCCACGATTCTGGgattggaaaaatatattgaacATCGGAAGCAAAACTGTCGGACTGCCGAAAAGCAGACAGTGACTACCACGGCGGAAGGTCCCGTCACCACATCAACTCCCACCCAAGTCTCGACTATCAGTCGCAGCAATTTGGACCACAGCTACGATGGCTTCCATTTCACGGAACCGGAAGCCCCCAGCAGTTATTTGCGGAAAACAGCAGCCAGTCACGGCGGAAAGACCTCAAAGTCCCTCACTGAAGCCTATGATCTGACCTATGAGCTGGGAGCTGACCTGTTCTTTTCTTCGCTGCAGCTGCAGAGTGTTTCCACGGGCGGGAAGACAGGGTCAGTGGCCCGACAGGAGAGGCCAAAGGAGGAGTCATGGCCAGCACCCGGAAGAGATCCTTTGCTGAAAGCTGTTCGGGAACACGAAGATACTGTTTTCAAGCCACTCAATTTCGACCACGACTCCCCGGAAGCCAGCGAGGATGAAGATGAGGAGGAAGAGCCCGATGATTTTGACCCGGAACCGGAGGAAGACGACGAGGAGTACGAGGTGAGGCGTCACTCGCCACCGGCCGTGCCCGTCACTCATACAGGTGGCAAGTGGAAGCCCGAGCACCGCCCGCAACTCCGGCATCCGCACATCGAACGCCTCTCGCCCAGCTGGGATGAGCCAGCCGAGGAGGTGTTCCCCCACCCGCCAGAGGATCACACTAAGGGCAAGTGGGTGCCCGGCAGCAAGCAGTTAGAGTACCGCGAAAACATAGACCTCACCAAGTTGGAGCAGCCGGGGGCCAGTTATTGGTGCAACATTTGCTGCCGGCGCTTGAAGAGTCGCCTGAACTACGAGCAACATTTGAAAAGTGGCTACCACTTGAAGAGGGCTGAGGCCGAATGCCAGTTGGAGCAGGCCACCCTGGGCAGAGAGCTCAGCCTGAGTAAAGAGTTTGCCGTGGAGGTCAAGGACAAGGAGAAGGATCCACCAGAACCGAAAAAGAGGCAGAGGCGAGCCAACCTCCTGCGCTGCGATCTTTGCCGGCACACAATGGCGCGCCACTTGATGGGAAAACACCTGATCTCCCATTACCATTACCGACgcctgcagcagcaacaaaaccAAATAAGGAGACAGGCGTCCCTGCAGGACATCCTTAACCACATGGGCAGCATAGTGAGGCAGTCCCCGTTTCAGTGCCTGCCCTGCAAATTTTATGCCAACTCGGAGGACACTTTCCTTGACCATTGGCAGTCCCAGACACACTCGGTCCTCACCCAGAAGCTGGGTGGCTCCTTCTGGTGTGGCTACTGTCAGTTCGAGTGCCGCACCAACGACGAGATGTGGATGCACCTGCTCCATGCCTCCCACAAGGAAGTGGTCATGGCTCTGAATCGGTCTGTCCCCATCTACATAGCCCAGAGACGTCATCTCCACTGCTCTAGTTGTGGGGTGCGATTCCTCTACAACATCCAACTGCGCCAGCACTTTGCGACCGAACATCCTGGCCAGGCTGCCACTGGCAGTGCTGCGGATGACTATCAGTGTCGCTTTCGGTGTGGCCTGTGCGGCATGCCGCAAAAATCCCGCCTGGCCCTGCAGCGCCACGAAAAGCACAAGCATCATGTGGCCAGGTATTACTGTGCCATTTGTCGGCTGGACTTTGAGACGCCTCTTGACGCACGACGCCATCGGAGCTTGTTGCAACACAAGCTGAAGGCTAGACCGAAAGTGTCCACAGTCCACTCGGACAAAGAAATTGAAAGTATGCTTCGGGAAGTGCTGGATGACACCGCAGACTCCAAAGCCAATCCCtcaaagaaaaccaaaactaTTCCCAAAAAATGCGCAAACTGCGAGGAGGTCTTTGATTCTCCTCAAAATTTAGCCCAACATCGAGCTGAGAAGCATCCTGCCGACAACCACGTCTGTCTGAGCTGTGGACTAAGCTTCCAATCGGCTCAAGCTTTGGGAAGGCATACCCGGAGCTGTCAGCCCAAGGCCAGCACATCCTCATCAGCATCCGCAACACCCGAAAATCCCAAGAACACCAGCTACTCCTGCGATCAGTGCCAGTTTCGCTCTCAATTCGAGTCTGATCTTATATACCATCGCTTCTTCCACACCCGTACAGGGAGTATCGCCAAAAACGAGCTCCTTCAGTGTCCGCTGTGCCCCAAGCACTTCAAAAAGCACTCCCTCAGAGCTCATCTCAGAAACCACACCGATGAGAGGATCTTCGAGTGTCCAGAGTGCAAGCTAAAATTTGCCAGAAGACACAACTTGAAGAACCATGTGGCCACCGTTCACGGGAAGAAGGAGGATCTGGAGGCGACTAAGCTGGCCAAGAAGAATGCAAGCgaacaaaacaaagccaaatacCAGTGTGGAACCTGTGGAAAAATTCTAGCTAAAAAgtacaGTCTTAAACTGCATGAGCTGAGCCACAAGGAGACAttgaaaaagaattttaaatgcCAGTTTCCGGAGTGTTCCTATGCGGGTCTGACCCAGGAAAGTCTGAAGACCCACCTCGTCTCCCACTCCCAGGGCACACACAAATGTGACCGGGAAAACTGCACCTATGTGGGGAAAAGTGAACTACATCTGAAGAGACACCTCAAGTCGGCCCATGCCGCGGAGAAGGATGGAGAGGAGTGGTACTCGTGCGATCAGTGCGAGTTCAGGGCCCGCATCAAGGGCCACCTTCGCCGGCACTCGCTGCGCCACTCGGGCCAGAAGCCCCACCAGTGCCCCCACTGCGACTTCCAGTGCAGCACCATCGACAACTTACGCAAGCACATCGTCAAGACCGGCAAGCATCCCGGCAAGTTCATCTACGAGTGCAAAAAGTGTGCGGACCTGGAATCCGGTGAAATATTTAAGAGCAACAGCTACAAGGACTACCATAAACATTTAAGTACACACAAAGTagactaa
Protein Sequence: MNPDDLEDTHLCIKCNATILGLEKYIEHRKQNCRTAEKQTVTTTAEGPVTTSTPTQVSTISRSNLDHSYDGFHFTEPEAPSSYLRKTAASHGGKTSKSLTEAYDLTYELGADLFFSSLQLQSVSTGGKTGSVARQERPKEESWPAPGRDPLLKAVREHEDTVFKPLNFDHDSPEASEDEDEEEEPDDFDPEPEEDDEEYEVRRHSPPAVPVTHTGGKWKPEHRPQLRHPHIERLSPSWDEPAEEVFPHPPEDHTKGKWVPGSKQLEYRENIDLTKLEQPGASYWCNICCRRLKSRLNYEQHLKSGYHLKRAEAECQLEQATLGRELSLSKEFAVEVKDKEKDPPEPKKRQRRANLLRCDLCRHTMARHLMGKHLISHYHYRRLQQQQNQIRRQASLQDILNHMGSIVRQSPFQCLPCKFYANSEDTFLDHWQSQTHSVLTQKLGGSFWCGYCQFECRTNDEMWMHLLHASHKEVVMALNRSVPIYIAQRRHLHCSSCGVRFLYNIQLRQHFATEHPGQAATGSAADDYQCRFRCGLCGMPQKSRLALQRHEKHKHHVARYYCAICRLDFETPLDARRHRSLLQHKLKARPKVSTVHSDKEIESMLREVLDDTADSKANPSKKTKTIPKKCANCEEVFDSPQNLAQHRAEKHPADNHVCLSCGLSFQSAQALGRHTRSCQPKASTSSSASATPENPKNTSYSCDQCQFRSQFESDLIYHRFFHTRTGSIAKNELLQCPLCPKHFKKHSLRAHLRNHTDERIFECPECKLKFARRHNLKNHVATVHGKKEDLEATKLAKKNASEQNKAKYQCGTCGKILAKKYSLKLHELSHKETLKKNFKCQFPECSYAGLTQESLKTHLVSHSQGTHKCDRENCTYVGKSELHLKRHLKSAHAAEKDGEEWYSCDQCEFRARIKGHLRRHSLRHSGQKPHQCPHCDFQCSTIDNLRKHIVKTGKHPGKFIYECKKCADLESGEIFKSNSYKDYHKHLSTHKVD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00550565;
90% Identity: iTF_00566405;
80% Identity: -