Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 2.9e-06 0.00025 21.5 0.4 1 23 173 195 173 195 0.99

2 5 4.9e-06 0.00042 20.8 4.8 1 23 201 223 201 223 0.98

3 5 1.9e-07 1.7e-05 25.2 1.3 1 23 229 251 229 251 0.99

4 5 1.1e-05 0.00097 19.6 0.5 3 23 259 279 257 279 0.98

5 5 3.1e-06 0.00027 21.4 1.7 1 23 285 309 285 309 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	2.9e-06	0.00025	21.5	0.4	1	23	173	195	173	195	0.99
2	5	4.9e-06	0.00042	20.8	4.8	1	23	201	223	201	223	0.98
3	5	1.9e-07	1.7e-05	25.2	1.3	1	23	229	251	229	251	0.99
4	5	1.1e-05	0.00097	19.6	0.5	3	23	259	279	257	279	0.98
5	5	3.1e-06	0.00027	21.4	1.7	1	23	285	309	285	309	0.93

Coding Sequence: ATGGAACTTAAACTGGATATGCTAACCGTGTGCCGGACTTGCCTACAGGACGGTGACGCCCAAATGATATCCATTTACGAGGTAgatgaggaaaaaaataaagatggGCTCTCCCTCTCCGAGAAAATAGAGGATTTTACGGGAATTCAAATAAATCGCAAAGAAGATCTTCCCACTAGAATTTGTCTGAAATGCAAAGCCTTTCTAACTCTAGCTCACAAATTCCGGCAAATTTGTCACAGATCTAATGAATTCCTCAGGGAATACGTGGTCAAGGATTCGTGCAATGGTGCGGCGACGGAGAAAGCCCAAGAAACCGAACAGTATGAGCAGCTAGGGGTCGAAGTACTTGAAGAGGAAATTTGGGGCACTGAGGAAACGATTGAGGAAACAGCTCCGCCTCCTTCTTCCGCTCCAGATGACTCTGTTGTTCCGCCATCGCAATTCCCAGATTCTAAGGATAACCCTGTTGTTTTGGCCGTAGAAACGGTACCGGCTCCGACAACAGGAAAGCTATATGTCTGTGATATATGCAAAAATGGATACCCTAGGAAGAGTACCTTGGCCACGCACATGCGGAGGCACAACAACGATCGACCCTACGAATGCGAgATTTGCCACAAACGCTTTCATGTTAACTATCAATTGATGCGCCACATTCGCCAGCACACTGGGGCCAAGCCGTATACCTGCGAATACTGCAATCGGAGTTTTGCAGATCGGACTTCTTTGGTCAAGCACGAAAGgACCCACCGGAATGAACGTCCTTATGGCTGTGATACCTGCGGTAAAACGTTTACCTATGCCAACGTCCTGAAAGTTCATTATAAAACGCACACAACCGAAAAGCCGTACACGTGCAGGCTATGTGAAAAGAGTTTCGCGCGCAACCACAACTTGGTGGCCCACTTGCAGACCCAACAGCATCTAAACGACCCCCGAACTCCTGCGTATTTGAACACTCTTAAGCTTGGAAATATTAGTTAG
Protein Sequence: MELKLDMLTVCRTCLQDGDAQMISIYEVDEEKNKDGLSLSEKIEDFTGIQINRKEDLPTRICLKCKAFLTLAHKFRQICHRSNEFLREYVVKDSCNGAATEKAQETEQYEQLGVEVLEEEIWGTEETIEETAPPPSSAPDDSVVPPSQFPDSKDNPVVLAVETVPAPTTGKLYVCDICKNGYPRKSTLATHMRRHNNDRPYECEICHKRFHVNYQLMRHIRQHTGAKPYTCEYCNRSFADRTSLVKHERTHRNERPYGCDTCGKTFTYANVLKVHYKTHTTEKPYTCRLCEKSFARNHNLVAHLQTQQHLNDPRTPAYLNTLKLGNIS

Sequence clustering based on sequence similarity using MMseqs2