Damb012219.1
Basic Information
- Insect
- Drosophila ambigua
- Gene Symbol
- -
- Assembly
- GCA_018150905.1
- Location
- JAECWS010000002.1:18288728-18290131[-]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 9 9.4e-06 0.00064 19.8 1.3 2 23 173 194 172 194 0.96 2 9 1.9e-06 0.00013 22.0 0.1 1 23 200 224 200 224 0.96 3 9 0.00097 0.066 13.5 2.1 1 23 231 256 231 256 0.96 4 9 0.00087 0.058 13.6 1.9 1 23 265 287 265 287 0.97 5 9 0.035 2.4 8.6 0.1 1 23 295 319 295 319 0.94 6 9 0.00096 0.065 13.5 2.1 1 23 325 347 325 347 0.97 7 9 0.0002 0.013 15.7 2.9 2 23 354 376 353 376 0.96 8 9 9.4e-05 0.0064 16.7 1.1 1 23 382 404 382 404 0.97 9 9 7.5e-06 0.00051 20.1 0.1 3 23 412 432 410 432 0.97
Sequence Information
- Coding Sequence
- ATGGATGGCCTGGACAAATGCCGCGTCTGTTGCTGCACCATTGAGTGCAAGGAGAAGGCCTGCAACTTGCTGCAGCTGCCCGAAGTGGCCGCAATGTTCACCGACTGCACGGATTTGTTGGTGGATCCGCGGGAGGATATGCCCAGTGTCCTCTGCTGTGGCTGCTACGAGGAGTTAAAAAAGTTCCATTCATTCCGTAAACTCTGCATAGAGGCGGACACCAAATGGCGCTTGCAGAAAAGGGACACACCTTTGGAATCGAAGTATACAATTGCGGAATCTGAGGACGGCTTCGAGGATGTGGACGACATGCCGCTTTGCGCATTGGAAACGAAAAGCCCGGGCCCCCCCATTGAAGCCACCGAGGTGGTGCTGGTCGATGGCGAATTCCATGAGAAAAAACCATGCCAAAGATTAAAGAAAGAAAATAGGGAAAAAGTAAAGAAAAGGACAGGGAGACGACCGAAGGTAAATGTAAAAGAGGTGCCCCCAACAGAAGAGCAGCGTGCGAGCTGCAAGTGCGAGATCTGCTCGAAAGAGTTTGTCGATGAGTATCGCCTGCAGGCGCACATGCGAGAGCACGATGGTCACCTGCTCTTTCCCTGCACAGAGCCTGGCTGTGACAAGAGCTTCAGTCGACTGCAGGATCTTAATGTGCACCTGCGGGAGCACAATGGCACGGGCACGTGGTATACCTGCGGCCAGGAGGGCTGCAGCAAGAGCTACCGCCACAAGGGCACGCTGGTGATGCACAAGCGCCAGAGCCATGGAATAGGACCGAAACTCAAGTTGCACGTGTGCGAATTCTGCGGCAGGGTCTTGAACAGTCTGGCAGCCCTCAACCACCATCGGTTCACGCACAAGGACAAGCTGGTGAAGCCGTATGCCTGCGAGGAGCCGGGCTGCTCGGTACGCTTTCTCAGCGAGGAGAAGCTCAAGGTGCACATGATGCGGCATAGGGGCATCAAGAACTTCACGTGTCCCCACTGCGGCGCCAAGAAGACAACAAAGAATGAGCTGAAGCTGCACATCAACTATCACACGCTGGAGCGCACCTGGCCCTGTCCGCACTGTCCCAAGGTGTGCAACAGCTCCACCAGCCGGAAGATGCACATACGCACGAATCACGAGAAGACCAAGAGCTATGCCTGCAGCATCTGTGACAAGAGATTCACCAAGCCGGACACGCGCAAGTATCACGAGTTGACGCACACGGGCGAGCGGAATTACGGGTGCGCAGTGTGTGGCAAGCGTTTCGTCCAGCCTGCGGCCCTGCGCACCCACCGAAAGATCCATGAGCGTGATCAGGCGAAGGCTCCTGTTGTTAAAGATGTGGAATCCTGA
- Protein Sequence
- MDGLDKCRVCCCTIECKEKACNLLQLPEVAAMFTDCTDLLVDPREDMPSVLCCGCYEELKKFHSFRKLCIEADTKWRLQKRDTPLESKYTIAESEDGFEDVDDMPLCALETKSPGPPIEATEVVLVDGEFHEKKPCQRLKKENREKVKKRTGRRPKVNVKEVPPTEEQRASCKCEICSKEFVDEYRLQAHMREHDGHLLFPCTEPGCDKSFSRLQDLNVHLREHNGTGTWYTCGQEGCSKSYRHKGTLVMHKRQSHGIGPKLKLHVCEFCGRVLNSLAALNHHRFTHKDKLVKPYACEEPGCSVRFLSEEKLKVHMMRHRGIKNFTCPHCGAKKTTKNELKLHINYHTLERTWPCPHCPKVCNSSTSRKMHIRTNHEKTKSYACSICDKRFTKPDTRKYHELTHTGERNYGCAVCGKRFVQPAALRTHRKIHERDQAKAPVVKDVES
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00473985;
- 90% Identity
- iTF_00564134; iTF_00611534;
- 80% Identity
- -