Basic Information

Insect: Drosophila ambigua
Gene Symbol: zfh1
Assembly: GCA_018150905.1
Location: JAECWS010000086.1:15559935-15583368[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.00071 0.048 13.9 1.2 2 23 75 97 74 97 0.95

2 9 0.0018 0.12 12.6 0.1 1 23 302 324 302 324 0.96

3 9 9.8e-05 0.0066 16.6 1.7 2 23 339 360 338 360 0.97

4 9 4.8e-06 0.00032 20.7 6.3 1 23 369 391 369 391 0.99

5 9 0.00028 0.019 15.2 1.2 3 21 399 417 397 418 0.94

6 9 0.008 0.54 10.6 1.8 2 21 667 686 666 687 0.92

7 9 1.3e-05 0.00086 19.4 0.5 1 23 1043 1065 1043 1065 0.94

8 9 4.7e-05 0.0032 17.6 7.4 1 23 1071 1093 1071 1093 0.98

9 9 0.0024 0.16 12.3 4.3 1 21 1099 1119 1099 1120 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.00071	0.048	13.9	1.2	2	23	75	97	74	97	0.95
2	9	0.0018	0.12	12.6	0.1	1	23	302	324	302	324	0.96
3	9	9.8e-05	0.0066	16.6	1.7	2	23	339	360	338	360	0.97
4	9	4.8e-06	0.00032	20.7	6.3	1	23	369	391	369	391	0.99
5	9	0.00028	0.019	15.2	1.2	3	21	399	417	397	418	0.94
6	9	0.008	0.54	10.6	1.8	2	21	667	686	666	687	0.92
7	9	1.3e-05	0.00086	19.4	0.5	1	23	1043	1065	1043	1065	0.94
8	9	4.7e-05	0.0032	17.6	7.4	1	23	1071	1093	1071	1093	0.98
9	9	0.0024	0.16	12.3	4.3	1	21	1099	1119	1099	1120	0.96

Sequence Information

Coding Sequence: ATGTTGTCCTGCCTGGCGCCGTCGTCTACACGTTTTGGCCAAGAGGATAACAGCATAATACAGCAGAGCATGCCATCGTCCACAGCCTTCACCATGCAGTTTCCCTCTTTGGCTTCCAGTCTGCACCACCACCAGGCACCGCACAGCAAGCCCAGCAATGGCTCCGCTGGCAGCCAGGAGCAGCACGCCCAGCCAGGTGTCTCCGTCGACGATTTCCTGGTCAAGTGCCCGCAGTGCCACAAACGCTTCACCGAGTTTCAGTCCCTCAGCGAGCACATTGCCAGCGAGCATCCGCACGATAAGCTGAACTTCGAGGCAAGTCGCGGCTCCAGCGGCGCCGTGCAGCCCGAGAGCGATGCCGAGGACGAGCAGAGCAACCTGAGTGGCAGCCGGTACGCCAAGTCGCCGGCAACCACCAGCCATGCCACCCCAAGCAACAACAACAACAACAGCGAGCTGGCCAAGAACCACAACAACAGCCACAGCAACGGCAACAGCAGTAAGCTCTCGCCCATGTGCTCTCCGGGATCGGTGGGTCCCGCCGCAGATCTCTTCGCCCACCTCTCACACGGAGCCCCGCCCCAGCTGCCCTCCCACCTGCACGCCCAGTTCATGGCCGCCGCCGCCCTGGCCATGCAGTCGGCCCGATCCGTCAGCTCCTCCGCCAGTTCGCCCAACAGCCACCATNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCGGGAAGCAACAGCAGTGTGGGCAGCAATTCCGCCTACGATCTGGACCTGAGTGCCCCACGGTCCACCTCCAGTCCGGGCTCCACCACCGGCGACCTGAGCGGCGCCTATCCCTGCATGCAATGCACCGCCGCCTTCAGCAGCCGCGAGCAGCTGGAGCAGCACGAGCTCCTCCACTCGCCCACCGGCGGCCAGCCCACGGCACAGAATGTCTCCCAGACTTGCCGAATCTGCCACAAAGCCTTCGCAAATGTGTACCGCCTGCAACGGCACATGATCAGCCACGACGAGTCGGCGCTGCTGCGAAAATTCAAGTGCAAGGAGTGCGACAAGGCGTTCAAGTTCAAGCACCACCTGAAGGAGCATGTGCGCATCCATTCCGGCGAGAAGCCCTTCGGCTGCGACAACTGCGGCAAGCGTTTCTCGCACTCCGGCAGCTTCTCCTCCCACATGACCTCCAAGAAGTGCATCAGCATGGGCCTCAAGCTGAACAACAATCGGGCGCTGCTCAAGCGCCTGGAGAAGAGTCCGGGCGCCGGGCCACGACGCTCGCCCACGGACCTGCAGGGCCCCAAAAACGGTGCCGGAAAGATGTCCGATCAGCAGTCCCTGCCACCGCTGCCCAATCCCATGATCTACTTTGCCGGCGAGGCGCAGGCGCAGGCTGCCGCTGCGAATGGAGCTCCTCCACCGTTCTACCCAAACTACATGAATGCGGCCCTGCTGGCCTTCCCCAATCCCTTCATGGCAGCGGCCCTGGATCCCCGTGTCCACCCCTACAGCATACAGCGGCTCCTGGANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGGAACGCGAGGAGCAGGAGCAGCACGAAGAGCCTGAGGCGCCGGAGGAGCCCAAGCTGGTCATGGACATTGATGAGGCCGAGGCCAAGGAGCGTATGGTGCCACACGCGAGCCCGCAAACCATGCCAGAGGAGATCGAACCCGTTGTCGCCATGGCCACTGCTCCCATCAAGCAGGAGCCCAGCCGCGAGCCCACTCCACTCCCGGAGAGTGCACCGCCCACGCCCAAGTCCTTCAAGCAGGAGCAAGAAGAGCCCCGTTGCCTGGAAGAGGATCAGCCCATGGCATCGGCTCAACCCGAAGCCTCTGTCTCCTCCCCAAGGGACACACCCGTCGAGCTGCGGTGCAGCCGCTGCGACAAGCAGTTCAATCACCACACAGAGCTGGTGCAGCACGAGAAGGTCCTCTGCGGCCTGATCAAGGAGGAGCNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNGCACCCTTTGCCCTGCCCTCGGCCAGCGAGGATGACGAGGAGGAGGAGGAGCGCGAGAACGACAACGACACGGAGCAGCGTCCGGACAGCAACGAGCGCAAGGTGCGCGTCCGCACGGCCATCAACGAGGAGCAGCAGCAGCAGCTGAAGCAGCACTACGCCCTCAATGCGCGGCCGAGTCGCGACGAGTTCCGAATGATTGCGGCCCGCCTCCAGCTGGATCCGCGCGTGGTCCAGGTCTGGTTCCAGAACAACCGCTCACGTGAGCGGAAGATGCAGAGCTATGCGACGGCAGCTCCAGCCGCCAATGAAGTGCCCACCACTCCGGTGACCAGCCGTCCCACAACCGAGGACCAGCCCCTGGATCTGTCCGTGAAGCGCGACTCCTTGACGCCCAAGAGCGACCACTCCGCCGTGTACGGATTGCCCCAGCAGCAGGCTGCCGGACAGCCAGCCCCCGCCGACTTCCAGGAGGCCATCAACCTGAGTCGCAAGTTCTCCAGCTCGGCCTCCATGTCGCCAGCCTCGCTGTCGCCCTCGTCGGGCGCCTCTCTGCAGCAATCCTCGGCAGCTGCGGCCGCCGCTGCGGCAGCCCTCTGGCCCTTTGGCGGGCAGCCTCCATCGCCGCCCAGCCAGCACGAGGCCACGCCCGCCCAGCACTGCTCGACGCCGCGCGGTGGCCAGGCCTTCCCGGGACTCCAGTACATGCTGCCAATGCAGCGGCTACCCATGGAGGCCCTCTTCCAGATGCGCCCTGGCGGCGAGTACGCCCCCAATCCCCTGATAAACAGTATTAAGATGCCCGACTTCCGCGGCACCAGCCTCAGTCCGGGCGGCTCCGAGAAGCGCTCCTGGCGGGACGACGACTCGCGCATCTCCCACGAGGACGACTTCGGCAACGGCTTGATGCCGCCCAAGCCACGCCGCGGCAAGGCAGAGACCCACGGGCATGCCGGGGATCCGGATCTGCCATTCGTCTGCGACCAGTGCGACAAGGCGTTTGCCAAGCAGAGCTCCCTGGCCAGGCACAAGTACGAGCATTCCGGTCAACGACCATACCAGTGCATGGACTGCCCGAAGGCCTTCAAGCACAAGCACCACCTGACGGAGCACAAGCGTCTGCATAGCGGGGAGAAGCCCTTCCAGTGCTCCAAATGCCTGAAGCGCTTCTCGCACTCGGGAAGCTACAGCCAGCACATGAACCACCGTTACTCCTACTGCAAGCCCTACAGGGAATAG
Protein Sequence: MLSCLAPSSTRFGQEDNSIIQQSMPSSTAFTMQFPSLASSLHHHQAPHSKPSNGSAGSQEQHAQPGVSVDDFLVKCPQCHKRFTEFQSLSEHIASEHPHDKLNFEASRGSSGAVQPESDAEDEQSNLSGSRYAKSPATTSHATPSNNNNNSELAKNHNNSHSNGNSSKLSPMCSPGSVGPAADLFAHLSHGAPPQLPSHLHAQFMAAAALAMQSARSVSSSASSPNSHHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDLSGAYPCMQCTAAFSSREQLEQHELLHSPTGGQPTAQNVSQTCRICHKAFANVYRLQRHMISHDESALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGLKLNNNRALLKRLEKSPGAGPRRSPTDLQGPKNGAGKMSDQQSLPPLPNPMIYFAGEAQAQAAAANGAPPPFYPNYMNAALLAFPNPFMAAALDPRVHPYSIQRLLXXXXXXXXXXXXXXXXXXXXXXEREEQEQHEEPEAPEEPKLVMDIDEAEAKERMVPHASPQTMPEEIEPVVAMATAPIKQEPSREPTPLPESAPPTPKSFKQEQEEPRCLEEDQPMASAQPEASVSSPRDTPVELRCSRCDKQFNHHTELVQHEKVLCGLIKEEXXXXXXXXXXXXXXXXXXXXXXXAPFALPSASEDDEEEEERENDNDTEQRPDSNERKVRVRTAINEEQQQQLKQHYALNARPSRDEFRMIAARLQLDPRVVQVWFQNNRSRERKMQSYATAAPAANEVPTTPVTSRPTTEDQPLDLSVKRDSLTPKSDHSAVYGLPQQQAAGQPAPADFQEAINLSRKFSSSASMSPASLSPSSGASLQQSSAAAAAAAAALWPFGGQPPSPPSQHEATPAQHCSTPRGGQAFPGLQYMLPMQRLPMEALFQMRPGGEYAPNPLINSIKMPDFRGTSLSPGGSEKRSWRDDDSRISHEDDFGNGLMPPKPRRGKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00603548;
90% Identity: iTF_00563802;
80% Identity: iTF_00474405;