Damb013794.1
Basic Information
- Insect
- Drosophila ambigua
- Gene Symbol
- -
- Assembly
- GCA_018150905.1
- Location
- JAECWS010000095.1:757755-764979[-]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 11 0.0002 0.014 15.6 3.4 1 23 275 297 275 297 0.98 2 11 0.0011 0.072 13.4 10.4 1 23 304 326 304 326 0.96 3 11 0.0001 0.0068 16.6 6.5 1 23 332 354 332 354 0.98 4 11 0.00046 0.031 14.5 1.6 1 23 360 382 360 382 0.95 5 11 2.2e-05 0.0015 18.7 0.5 1 23 388 410 388 410 0.97 6 11 1.5e-05 0.00098 19.2 0.1 1 23 416 438 416 438 0.98 7 11 0.00012 0.0083 16.3 2.0 1 23 443 466 443 466 0.97 8 11 0.052 3.5 8.1 0.3 1 23 472 495 472 495 0.94 9 11 0.00017 0.011 15.9 0.1 1 23 560 582 560 582 0.98 10 11 0.015 1 9.7 2.7 1 23 698 720 698 720 0.95 11 11 0.0044 0.3 11.4 4.9 5 23 733 751 725 751 0.92
Sequence Information
- Coding Sequence
- ATGTGCGCCGCCCAGAACCCACAGCCGCCCTTCGGCTACACCTGGGGCTTCGCAGACAACGGCAGCCGTACCGCCGAATCGGTTCTGGAGATATCGCCCAACATTAACTACACCGTCAGTGGGGAATCGATGCCCTATCTGCTGTCCACGGATGGATCATTGGCCGTACAAAAGGATGTCAAAGGTGCTCTCAGCGGCAATAAGGGGAATGTTGTGCGTCGCATGTACGTTGTGAACGATCCTTCGTTTCCGCCGGGTACACAGAGAGTAATAACCACTGGGGGCGGCTCGTCGGTAGTCAAGAAACAGGATTCGCAGCAGCAGGTGCTGAGCCTGGACAAGAACTATCTCCTGGTCGATCAGGCAACTGCAGCAGCAGCTGCAGCCGCGGCGGCCGGTGATCCCTCGGTTGCCCACCACCACACATTGACCAACGGTAGTATTGTTGATGCCAAGACCGGACAGACGGTGCTGACGGCGGGCTCAGCGGCGGCCAAGTCGCACTTTGGGTCGATCGGGGCGCTGCACCTCACCCAAGAGGAGTGTAACGAGATCCTTATTAAGCGCGCCATCGCTGCCGGCCACCATCAGACGCACACAATCACCGCTGCCGACGGATCGCATCATCATAGCTCGGCGTCTGGCGCGACACCAATTCAAGTCCAGAAAGTAATACAAGGACTCGAAGAGAACGAGGACTCGCAGGGCGACGCACCCAACTTAAAGTTGGAGCCAGGCACATTAGAGTTGTCCCCAAAGACCGAACTACAGGAATCAATGCATTTCAGCGAAACGGACGCCACCATCAAGAAGGAACGCCCGTACAGTTGCGACGAGTGCGGCAAGTCCTTTCTGCTCAAGCATCATTTGACAACACACGCACGCGTGCACACAGGTGGTGAGCGACCCCATATCTGTTCCCATTGCGGCAAGAGCTTTGCGCACAAACACTGTCTGAACACGCATCTACTGCTGCACTCAACCGACCGACCCTACCAGTGCCAGGAGTGCAAGAAGAGCTTCACCCTCAAGCATCATCTGCTGACGCACTCGCGCGTCCACAGCCGCGAGCGACCCTTCGTGTGCCAGGAGTGCGGACGTGCCTTCCCGCTTAAGCGGCACCTGGTCACGCACAGCAAATTCCACGCCGGCGAACGTCCATACGTCTGCGAGGAATGCGGTGAGAGCTTTGCCCAGGAAAACCATCTTATTATGCACTCGCGCTTCCATGGTTCATTGAATCCATTTGTTTGCGCTGACTGCGGTGCCTCGTTTCCACGCAAGTTCCAGTTGGTGAATCACGGACGCATACACGGCAAGATCCCCCACTCCTGCACCGTTTGCGGAAAAGAGTTTTTACAGAAGCGAACACTAGTTTCCCACATGAGACGCGTACACACGGGCGAGCAGGCGCATCCCTGCGTCAGCTGCGGCGAGGGATTCCTCACCAAGGCTGAGCTGCACCAGCACGTGCGGGCAGCTCACAACGGCGTCAATCCTAATACGAGCAGTGCCACCATCATTGCCAACCAGCAGTTTATCGATTTCAAGCAGCTGCAACAGCCTCACCACCATCCCGGACAGCATCCGCAGACGATCACCGTCGTGAGTAATCCGGGCAACTCTACGCTTCTCACGGTCTCCACTACGGATGCCAATGGTGTGGCGCGTCCGCAGTTCGTTTGCCGCGAGTGCGGTAGCGCCTTCAACAGCCGCGAGGCCTTGGCCTTGCACTTGCGCCTGCACACCGGCGACAAGAGCCTCATGACCGATTTGTGCGCCTTGACAGCAGCGCTGCCGGGTCACTTCTTGAGCACGGCCGGCCTGAACCCGGGCACTGTGGTGACGGCCAACCCGAATTTGGTGGGCCAGAATCCAGTGCCCGTGCAGATCATATCGTCCACCGGCCAGGTTATGTCGCAGACCACGCTGGTGCAGGCCGCCAACTCGACCCATCCGCAGGCCGTCGTCACTGCCGTGCCAACGATGCCCGTGCATCAGCAGCAGCACATGCAGCATGTGGCCCAGCAGCAACAGCAGCAGCAGCAACAGCACGTGGTCAATGTGGTGCCGGCCAACAAGCCCAAGTCGCATTTCTGCGCCAGCTGTGGCAAAGGATTCGCTGCCAAGCACGGCCTCATGCAGCACAACCGCCGCCATCCGAATGGCGGCTGCACGGTGCGCACCCACGTCTGCGAGTGCGGCAAGGCCTTCTTCCAGAAGAACCATCTGATGCTGCACCAGCGCCAGCACTTGGAGACGAAGCCAGCCATATCGCAGCAACAGGAGCAGCAACAACAGGAGGCAGTAGTGGCAGCGTCGGCGGCTGGACAGCAACCGGTGCAGGTGCAGATCCTGCCCGATGGTCATATACACGGCAAGGTCATCAAGTACGAGATTTGTCGCAGTGTGCTGCCAGAGGATCAGGCCACAGCACAGCAACAGCAGCAGGCAGGCATGGACGTCGAGTAG
- Protein Sequence
- MCAAQNPQPPFGYTWGFADNGSRTAESVLEISPNINYTVSGESMPYLLSTDGSLAVQKDVKGALSGNKGNVVRRMYVVNDPSFPPGTQRVITTGGGSSVVKKQDSQQQVLSLDKNYLLVDQATAAAAAAAAAGDPSVAHHHTLTNGSIVDAKTGQTVLTAGSAAAKSHFGSIGALHLTQEECNEILIKRAIAAGHHQTHTITAADGSHHHSSASGATPIQVQKVIQGLEENEDSQGDAPNLKLEPGTLELSPKTELQESMHFSETDATIKKERPYSCDECGKSFLLKHHLTTHARVHTGGERPHICSHCGKSFAHKHCLNTHLLLHSTDRPYQCQECKKSFTLKHHLLTHSRVHSRERPFVCQECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFAQENHLIMHSRFHGSLNPFVCADCGASFPRKFQLVNHGRIHGKIPHSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKAELHQHVRAAHNGVNPNTSSATIIANQQFIDFKQLQQPHHHPGQHPQTITVVSNPGNSTLLTVSTTDANGVARPQFVCRECGSAFNSREALALHLRLHTGDKSLMTDLCALTAALPGHFLSTAGLNPGTVVTANPNLVGQNPVPVQIISSTGQVMSQTTLVQAANSTHPQAVVTAVPTMPVHQQQHMQHVAQQQQQQQQQHVVNVVPANKPKSHFCASCGKGFAAKHGLMQHNRRHPNGGCTVRTHVCECGKAFFQKNHLMLHQRQHLETKPAISQQQEQQQQEAVVAASAAGQQPVQVQILPDGHIHGKVIKYEICRSVLPEDQATAQQQQQAGMDVE
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01556276;
- 90% Identity
- iTF_00603515;
- 80% Identity
- -