Damb014727.1
Basic Information
- Insect
- Drosophila ambigua
- Gene Symbol
- Hsf
- Assembly
- GCA_018150905.1
- Location
- JAECWS010000095.1:7576533-7579852[+]
Transcription Factor Domain
- TF Family
- HSF
- Domain
- HSF_DNA-bind domain
- PFAM
- PF00447
- TF Group
- Helix-turn-helix
- Description
- Heat shock factor (HSF) is a transcriptional activator of heat shock genes [1, 4]: it binds specifically to heat shock promoter elements, which are palindromic sequences rich with repetitive purine and pyrimidine motifs [1]. Under normal conditions, HSF is a homo-trimeric cytoplasmic protein, but heat shock activation results in relocalisation to the nucleus [2]. Each HSF monomer contains one C-terminal and three N-terminal leucine zipper repeats [3]. Point mutations in these regions result in disruption of cellular localisation, rendering the protein constitutively nuclear [2]. Two sequences flanking the N-terminal zippers fit the consensus of a bi- partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus [3]. The DNA-binding component of HSF lies to the N terminus of the first NLS region, and is referred to as the HSF domain.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 2e-36 1.5e-32 111.8 1.3 1 100 49 148 49 148 0.97
Sequence Information
- Coding Sequence
- ATGTCCAGGCCGCGTTCATCTGTAAAAGCCGTGCAACACAGGCACGAGTCAAGCGAGGAGGAGGACGACGAAGAGGAGCAGCGCTCTCCGCGTCGCAATATGCATTCATTCGGGGATTCGAGCATGGGCAGCGGTGTGCCCGCCTTTCTTGCCAAGCTCTGGCGTCTGGTGGAGGACACCGAAACCAATCATTTGATTTGTTGGACAAAGGATGGCCACAGCTTTGTCATACAAAACCAGGCGCAATTCGCGAGGGAACTACTGCCGCTCAACTACAAGCACAACAACATGGCCAGCTTCATCAGGCAGCTGAATATGTATGGATTTCATAAGATCACATCTATTGAGAATGGCGGCTTGCGGTTCGATCGCGACGAGATCGAGTTCTCCCATCCGTTCTTCAAGCGCAACTCTGCGTATCTGCTGGACCAAATAAAGCGAAAGATATCCAACAACAAGAATGTGGATGACAAGGCGGTGATGAAGCCGGAGGCTGTGTCCAAGATATTGAACGATGTGAAGGTGATGCAGGGCCGGCAGGATACCATGGACTCGCGCTTCTCAGCCATGAAGCAGGAGAACGAAGTGCTGTGGCGCGAAATCGCCAGTCTTCGGCAGAAGCATTCGAAGCAGCAGCAGATAGTCAACAAATTGATACAGTTCCTCATTTCGATCGTGCAGCCATCAAGGAATATGTCAGGAGTGAAGCGGCACATGCAGCTCATGATCAATGATACGCCGGAAAATGCACGCGCGCGTACCACCAGCGAAACGGAGAGCGAAGGTGGCAGTGGCCCTGTTATACACGAGCTCAGCGAGGAGCTGCTCGACGAAGTAATGAATCCCTCGCCTAATCGATACGCCAACGCCGCTCACTATGACCAGGAGAGCGCCTCTCCACAGTCCGTTGAGCGTCCACAGTCAATTAATTTTGACTACTCCAATCAGAGCGTCGAGGACTTGCTGCGGACTAACAATGGAGGAGGTGGCAATCTTCTGCAAGTGGGGGCTGGAGCTGCCTCCCCTCTGGTCAGTCAGTCGCCGTCTGAACAAATTGCATATACAGTGACCGAGCTCCCGGATGCTCATGTCCCAGAGGTGTCCAGCAGTCCTGTCTACACCGATGAGCATAATGTGCTCACGCCCCTGGTGCGTGAACAGCAGCGTGAGGAGGAGCGCCAGCAGCGCCAGCAACTGAAGGAGAAAAACAAACAGCGGCGACAGGCCGGAGATCAGATGCTTGCCGCCAACGCCATCTTAGTCGAAGAAGGCTCTCCCAAGACTGTGCGCACGCGCTCCCAGCTCAAAACGGATTCACAGTCCAATGTGATGCCGCAGCCTGTATTCATCAAGACAGAGCCCGAAACCGATTCCGGATTGCTAGACCTGATGAATGGCACGGACTCGGACATGTACAACGTGAACTTTATCAGCGAAGATATGCCGTCGAATATATTTGAGGACTCCTCAACGCTCTCGACTGATGTTGGCGGGGCTGACAAGTTGAATCAGCAGCAGACATTCGGCAAGTCCACAGTCGGCAGTGGAAAGTTTGCTGGCAACTTTGATGTGCCCATTACTGGCAGTAGCAGCAGCCGCTCTCTGCTAGACGCCAATCAGGCATCCACTTCGAGAGCAGCGGCAGCCACAAAGGCCTCAGCATCAGCCTCAGCCACTGAGGGCGAGGCAGCAGCCATGGCTGTGACCAAGTATGCGGGCGAAAACAGTGCTGTTCGGGAGGGGAGCAATGGTCCTCTGATAAGGATTAATTCTGTTGACGATGTCCATGGGCATTTGGATAATGTGCAAGATGAGCTTGAGACCCTCAAGGATTTGCTGCGTGGCGACGGCGTCTCCATCGATCAGAACATGCTTTTGGGTGCTCTGGCTAGGACGTCCATTTTGCAGCTGACCGAAGACGACCAGTTGATAAAGCTCTTCAATGACTCGGAACTATTGGACACCTACGGCCTATCGTTTCCCCTTGACAGCATGAGCGGTGACAAGAAAGCTTCGAACGGCTCGCAAATGATGGCCTATCAGCCCAGCCCGTACGATCTATCCGACATACTGGACACAGACGACAATGAAAAGAGCCAGGAGCCCATCAGTCGTCAGTCGTTTCAAACGCAGAGTTCAGTTTTGAATACACCGCGACACGATTTTTAA
- Protein Sequence
- MSRPRSSVKAVQHRHESSEEEDDEEEQRSPRRNMHSFGDSSMGSGVPAFLAKLWRLVEDTETNHLICWTKDGHSFVIQNQAQFARELLPLNYKHNNMASFIRQLNMYGFHKITSIENGGLRFDRDEIEFSHPFFKRNSAYLLDQIKRKISNNKNVDDKAVMKPEAVSKILNDVKVMQGRQDTMDSRFSAMKQENEVLWREIASLRQKHSKQQQIVNKLIQFLISIVQPSRNMSGVKRHMQLMINDTPENARARTTSETESEGGSGPVIHELSEELLDEVMNPSPNRYANAAHYDQESASPQSVERPQSINFDYSNQSVEDLLRTNNGGGGNLLQVGAGAASPLVSQSPSEQIAYTVTELPDAHVPEVSSSPVYTDEHNVLTPLVREQQREEERQQRQQLKEKNKQRRQAGDQMLAANAILVEEGSPKTVRTRSQLKTDSQSNVMPQPVFIKTEPETDSGLLDLMNGTDSDMYNVNFISEDMPSNIFEDSSTLSTDVGGADKLNQQQTFGKSTVGSGKFAGNFDVPITGSSSSRSLLDANQASTSRAAAATKASASASATEGEAAAMAVTKYAGENSAVREGSNGPLIRINSVDDVHGHLDNVQDELETLKDLLRGDGVSIDQNMLLGALARTSILQLTEDDQLIKLFNDSELLDTYGLSFPLDSMSGDKKASNGSQMMAYQPSPYDLSDILDTDDNEKSQEPISRQSFQTQSSVLNTPRHDF
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00611270; iTF_00563818; iTF_00603262; iTF_00600973; iTF_00473698; iTF_00574728; iTF_00484362; iTF_00471531; iTF_00487215; iTF_00580631; iTF_00514808; iTF_00535961; iTF_00517628;
- 90% Identity
- iTF_00611270;
- 80% Identity
- -