Basic Information

Insect: Drosophila algonquin
Gene Symbol: hb
Assembly: GCA_035041765.1
Location: JAWNKY010000824.1:1143210-1145582[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00018 0.015 15.9 0.2 1 23 254 276 254 276 0.99

2 6 0.0061 0.51 11.1 4.5 2 23 284 305 283 305 0.97

3 6 0.00026 0.022 15.4 5.0 1 23 311 333 311 333 0.98

4 6 0.034 2.8 8.7 5.3 1 23 339 363 339 363 0.93

5 6 9.6e-05 0.008 16.8 0.4 1 23 737 759 737 759 0.96

6 6 0.0031 0.25 12.0 0.2 1 22 765 786 765 789 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00018	0.015	15.9	0.2	1	23	254	276	254	276	0.99
2	6	0.0061	0.51	11.1	4.5	2	23	284	305	283	305	0.97
3	6	0.00026	0.022	15.4	5.0	1	23	311	333	311	333	0.98
4	6	0.034	2.8	8.7	5.3	1	23	339	363	339	363	0.93
5	6	9.6e-05	0.008	16.8	0.4	1	23	737	759	737	759	0.96
6	6	0.0031	0.25	12.0	0.2	1	22	765	786	765	789	0.91

Sequence Information

Coding Sequence: ATGCAGAACTGGGAGACGACTCCGGCCGCCAGCTACGAGCAGCACAATCCATGGTACAGCAGCATGTTTGCGGCAAACATTAAGCAGGAGCCGGGAttgaccagcagcaacagtgtgGCCAGCGGCAGCCCCAGCCCGAGGCAGTCGCCACTGCCATCGCCGGGAAATCACTTGGAGCAGTACctcaaacagcagcagcagcagcaccagcagcaacagttgcaacaACAGCCCATGGATACCATGTGTGGGGCAGCAATGACACCATCGCCGAGCCAGAATGATCAGAATAGTCTGCAGCACTTTGATGTGACGCTGCAGCAACAgttgttgcaacagcagcaataccaGCAGCACTTTCAGGcagcgcaacaacaacagcagcagcaggcccaccaccatcatcatcacttGGGACTAGGTGGATTCAATCCATTGACACCGCCAGGATTGCCCAATCCCATGCAGCATTTCTATGCCGGAAATCTGGGTCGCCCCAGTCCACAGCCAACGCCAACGGCAACCCAAGTGGTGGCACCCACACAAGTGGGGGAGAAACTGCAAGCCCTGACGCCACCCATGGATGTGACGCCACCAAAGTCACCAGCCAAATCCATGGATAAGGAGCTGCTGCACCACGAAAAGGAGCACGATCAGATgtccaactccagtgaggataTGAAATACATGGCCGAGTCCGAGGATGATGATCAGAACATTCGCATGCCCATCTACAATTCGCATGGAAAGATGAAGAACTACAAATGCAAGACATGCGGTGTGGTGGCCATCACAAAGGTGGACTTTTGGGCGCACACCCGCACCCACATGAAGCCCGACAAGATTCTGCAGTGCTCCAAGTGTCCCTTTGTGACGGAATTCAAGCATCATCTGGAGTATCACATCCGGAAGCACAAGAACCAGAAGCCCTTCCAGTGCGACAAGTGCTCCTACACGTGCGTCAACAAATCCATGCTGAACTCCCACCGCAAGTCGCATTCATCCGTGTATCAGTATCGTTGTGCGGACTGTGACTATGCCACCAAATACTGCCACAGCTTCAAGCTGCATCTGAGGAAATATGGCCACAAGCCCGGCATGGTCTTGGATGAGGACGGCACACCCAATCCTTCGCTGGTGATTGATGTCTATGGCACGAGACGTGGTCCCAAGAGCAAGAATGGTGGCActgaaaggagcagcagcagtggcaccagcagcagcagcagtcgaaaGAGCAacgtggcagcagtggcaccacaacagcaacaacagcagcagccacagcagccaccagtAGCAGCAGTCACCTCGCAGTTGAGTGCCGCCCTGCAAGGATTCTCCACATCGGTGTCAGCACCCTCGCCAGTAATGCCCGCCTCTCCAGCCAAGAgtgtggcaagcagcagcagcaaagcggatcagcagcagcagcaacatcagcaacagcagcagcagtctccTGCCAATCTCCTGCCGCCGCTGGCCAGCCTTCTGCAGCAGAATCGCAACATGGCCTTCTTCCCCTACTGGAATCTCAATCTCCAGATGTTGGCCGCACAGCAGCAGGCCGCAGTTTTGGCACAACTTTCCCCACGAATGCGAGAGcagctccaacagcagcagcagcaacagcaccactcgcagtcgcagtcgcagcacAGCGAcaatgaggatgaggagcagGATGATGAGTACGAGCGCAAGTCGGTGGATTCTGCCATGGATCTGTCCCAGGGAACACCCGTGAAAGATGACGAAcagcatccacagcagcagcagcagcaacagcagcagcagcagaagccctTGGCGATGGTCATGAATCTGAAGCACGAGGAGGAGGCCACTCCTCTGATGAGCAGCACGAATGCCTCACGGCGCAAGGGTCGTGTCCTGAAGCTGGATACCCTCCTGCAAATGAAATCCGCGGCATTGACCTCCCCAGAGCAACTAAAGGTTATGCCCACCGCATCATCGCCCATTGCAGGACGCAAGCAGCTACCCGAAGAGCATTGTTCGGGTGCCAGCTCTGCGGATGAGTCGATGGAGACGGCGCATGTACCTCAGGCTAATACGAGTGCCAGTTCCACTGCCTCCAGCTCTGGGAATAGCtccaatgccagtgccagtagCAATGGGAACAGCAGCTCCAACAGTACAGCAGCACCCGTTGTGGCATCCacaccagcggcagcaggggcCATCTACGAGTGCAAGTACTGTGATATCTTCTTCAAGGATGCGGTGCTCTACACCATCCACATGGGCTATCACAGCTGCGACGATGTGTTCAAGTGCAACATGTGCGGCGAGAAGTGCGACGGACCCGTCGGCCTCTTCGTTCACATGGCACGCAATGCGCACTCCTAA
Protein Sequence: MQNWETTPAASYEQHNPWYSSMFAANIKQEPGLTSSNSVASGSPSPRQSPLPSPGNHLEQYLKQQQQQHQQQQLQQQPMDTMCGAAMTPSPSQNDQNSLQHFDVTLQQQLLQQQQYQQHFQAAQQQQQQQAHHHHHHLGLGGFNPLTPPGLPNPMQHFYAGNLGRPSPQPTPTATQVVAPTQVGEKLQALTPPMDVTPPKSPAKSMDKELLHHEKEHDQMSNSSEDMKYMAESEDDDQNIRMPIYNSHGKMKNYKCKTCGVVAITKVDFWAHTRTHMKPDKILQCSKCPFVTEFKHHLEYHIRKHKNQKPFQCDKCSYTCVNKSMLNSHRKSHSSVYQYRCADCDYATKYCHSFKLHLRKYGHKPGMVLDEDGTPNPSLVIDVYGTRRGPKSKNGGTERSSSSGTSSSSSRKSNVAAVAPQQQQQQQPQQPPVAAVTSQLSAALQGFSTSVSAPSPVMPASPAKSVASSSSKADQQQQQHQQQQQQSPANLLPPLASLLQQNRNMAFFPYWNLNLQMLAAQQQAAVLAQLSPRMREQLQQQQQQQHHSQSQSQHSDNEDEEQDDEYERKSVDSAMDLSQGTPVKDDEQHPQQQQQQQQQQQKPLAMVMNLKHEEEATPLMSSTNASRRKGRVLKLDTLLQMKSAALTSPEQLKVMPTASSPIAGRKQLPEEHCSGASSADESMETAHVPQANTSASSTASSSGNSSNASASSNGNSSSNSTAAPVVASTPAAAGAIYECKYCDIFFKDAVLYTIHMGYHSCDDVFKCNMCGEKCDGPVGLFVHMARNAHS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00536310;
90% Identity: iTF_00471920;
80% Identity: -