Basic Information

Insect: Drosophila algonquin
Gene Symbol: zfh1
Assembly: GCA_035041765.1
Location: JAWNKY010000678.1:543076-569276[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.0027 0.23 12.2 1.9 2 23 75 97 74 97 0.95

2 9 0.002 0.17 12.6 0.1 1 23 314 336 314 336 0.96

3 9 0.00011 0.009 16.6 1.7 2 23 351 372 350 372 0.97

4 9 5.3e-06 0.00044 20.7 6.3 1 23 381 403 381 403 0.99

5 9 0.00031 0.026 15.1 1.2 3 21 411 429 409 430 0.94

6 9 0.0089 0.74 10.6 1.8 2 21 678 697 677 698 0.92

7 9 1.4e-05 0.0012 19.4 0.5 1 23 1057 1079 1057 1079 0.94

8 9 5.3e-05 0.0044 17.6 7.4 1 23 1085 1107 1085 1107 0.98

9 9 0.0026 0.22 12.2 4.3 1 21 1113 1133 1113 1134 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.0027	0.23	12.2	1.9	2	23	75	97	74	97	0.95
2	9	0.002	0.17	12.6	0.1	1	23	314	336	314	336	0.96
3	9	0.00011	0.009	16.6	1.7	2	23	351	372	350	372	0.97
4	9	5.3e-06	0.00044	20.7	6.3	1	23	381	403	381	403	0.99
5	9	0.00031	0.026	15.1	1.2	3	21	411	429	409	430	0.94
6	9	0.0089	0.74	10.6	1.8	2	21	678	697	677	698	0.92
7	9	1.4e-05	0.0012	19.4	0.5	1	23	1057	1079	1057	1079	0.94
8	9	5.3e-05	0.0044	17.6	7.4	1	23	1085	1107	1085	1107	0.98
9	9	0.0026	0.22	12.2	4.3	1	21	1113	1133	1113	1134	0.96

Sequence Information

Coding Sequence: ATGTTGTCCTGCCTGGCGCCGTCGTCTTCACGTTTTGGCCAAGAGGATAACAGCATCATACAGCAGAGCATGCCATCGTCCACAGCCTTCACAATGCAGTTTCCCTCTTTGGCTTCCAGtctgcaccaccaccaggcaCCGCACAGCAAGCCGATCAATGGCTCCGGTGGCAGCCAGGAGCAGCACGCACAGCCAGGTGTATCCGTCGATGATTTCCTGGTCAAGTGCACGCAGTGCCACAAACGCTTCACAGAGTTTCAGTCCCTCAGCGAACACATTGCCAGCGAGCATCCGCACGATAAGCTGAACTTTGAGGCAAGTCGTGGCTCCAGCGGCGCCGTGCAGCCGGAGAGCGATGCCGAGGACGAGCAGAGCAATCTGAGTGGCAGCCGATATGCCAAGTCCCCTGCCGCCACCACCCATGCCAcgcccagcaacaacaacaacaacagcgatcTGGCCaagaaccacaacaacaacaacaacagcaacagcagcagcagtaagcTCTCTCCGATGTGCTCTCCCGGCTCGGCGGGtcccaccaccgccgccgcagaTCTCTTCGCCCACCTCTCACACGGAGCCCCGCCCCAGCTGCCCCCCCACCTGCACGCCCAGTTcatggccgccgccgccctggCCATGCAATCGGCCCGCTCCGTCAGCTCCTCCGCCAGTTCGCCCAGCagccaccatcaccaccagcagcaccagcagcaccagcagcaacagcagcagcagcagtcgcaccttcatcatcaccagcaccagcagcagcagcagctccaccagcagcagtcgcagcagcagctgctgccgccccaGCTAccgggcagcaacagcagcgtggGCAGCAATTCCGCCTACGATCTGGACCTGAGTGCCCCACGCTCCACCTCCAGTCCGGGCTCCACAACCGGCGACCTGAGCGGCGCCTATCCCTGCATGCAATGCACCGCCGCCTTCAGCAGCCGCGAACAGCTGGAGCAGCACGAGCTCCTCCACTCGCCCACCGGGGGCCAGCCCACGGCACAGAATGTCTCTCAGACCTGCCGAATCTGCCACAAAGCCTTCGCGAATGTCTACCGCCTGCAACGGCACATGATCAGCCATGACGAGTCGGCGCTACTGCGTAAATTCAAGTGCAAGGAGTGCGACAAGGCCTTTAAATTCAAGCACCACCTGAAGGAGCATGTGCGCATCCATTCCGGGGAGAAGCCCTTCGGCTGCGACAACTGCGGCAAGCGATTCTCGCACTCCGGCAGCTTCTCCTCCCACATGACCTCCAAGAAGTGCATCAGCATGGGTCTCAAGCTGAACAACAATCGGGCGCTGCTCAAGCGCCTGGAGAAGAGTCCTGGCGCCGCCGGTCCCCGACGCTCTCCCACGGACCTACAGGGACCCAAAAACGGTGCCGGAAAGATGTCCGATCAGCAGTCCCTGCCACCGCTGCCCAATCCCATGATCTACTTTGCCGGCGAGGCACAGGCGCAAGCTGCGGCTGCGAATGGAGCTCCTCCACCATTCTATCCCAACTACATGAACGCGGCCCTGCTGGCCTTTCCCAATCCCTTCATGGCAGCGGCCCTGGATCCGCGCGTCCATCCGTACAGCATACAGAGACTTCTGGAGCTGACGGCCGccggacagcagcaacaacatcagcagcagcaacgcgaGGAACGcgaagagcaggagcaggatcaGCACGAAGAGCCTGAGACGCCGGAGGAGCCCAAGCTGGTCATGGACATCGATGAGTCTGAGGCCAAGGAGCGTATGGTGCCACAAGCAAGCCCTCAGACCATGCCAGAGGAGATCGAACCCGTTGTCGACATGGCCGTTGCTCCCATAAAGCAAGAGCCCAGCCGCGAGCCCACCCCACTCCCGGAGAGTGCACCGCCCTCGCCCAAGTCCTtcaagcaggagcaggaggagcccCGTTCCGTAGAGGAGGATCAGCCCATGGAATCGGCTCAGCCCGAAGCCTCTGTCTCCTCCCCCAGGGTGGACACACCGGCCGAGCTGCGGTGCAGCCGCTGTGACAAACAGTTCAACCACCACACGGAGCTGGTGCAGCACGAGAAGGTCCTCTGCGGCCTGATAAAGGAGGAGCTCGAGCAGCAttaccaccagcagcaccaacagcaacagcaccaccaacatctccagcagcagcagcaggcagccttTGTCCTGCCCTCTGCCAGCGAGgatgacgacgaggaggaggagcgcgaGAACGACAACGACACGGAGCCACGTCAAGACAGCAACGAGCGCAAGGTGCGCGTACGCACAGCCATCAACgaggagcaacaacagcagctgaagcagcaCTACGCCCTCAATGCGCGGCCGAGTCGCGACGAGTTCCGGATGATTGCGGCCCGCCTCCAGCTTGATCCGCGAGTGGTCCAGGTCTGGTTCCAGAACAATCGGTCACGCGAGCGCAAGATGCAGAGCTATGCGAATGTCCACACTGCAGCTCCAGCCGCCAATGAAGTGCCCACTACTCCAGTGGCCAGCCGTCCCACGACCGAGGATCAGCCCCTGGATCTGTCGGTGAAGCGCGACTCCTTGACGCCCAAGAGCGACCACTCCGCCGTGTACGGAttgccccagcagcaggctgCCGGACAGCCAGCCCCCGCCGACTTCCAGGAGGCCATCAACCTGAGCCGCAAGTTCTCCAGCTCGGCCTCCATGTCACCAGCCTCGCTGTCGCCCTCGTCGGGCGCCTCTCTGCAGCAATCCTCGGCAGCTgcggccgccgctgctgcagccctCTGGCCCTTCGGCGGCCCGCCTCCATCGCCGCCCAGCCAGCACGAGGCCACGCCCGCCCAGCACTGCTCGACGCCGCGTGTCAGCCAGGCTTTCCCCGGACTACCGTACATGATGCCCATGCAGCGGCTTCCCATGGAGGCCCTCTTCCAGATGCGCCCTGGCGGCGAGTACGCCCCCAATCCCCTGATGAACAGTATTAAGATGCCCGACTTTCGCGGCACCAGTCTCAGTCCGGGCGGCTCCGAGAAGCGCTCCTGGCGGGACGACGACTCGCGCATCTCCCACGAGGACGACTTCGGCAACGGCCTGATGCCGCCCAAGGGCCGTCGTGGCAAGGCCGAGACCCACGGGCATGCCGGCGATCCGGATCTGCCCTTTGTCTGCGACCAGTGCGACAAGGCGTTCGCCAAGCAGAGCTCCCTGGCGAGGCACAAGTACGAGCATTCCGGTCAAAGACCCTACCAGTGCATGGACTGCCCGAAGGCCTTCAAGCACAAGCACCACCTGACGGAGCACAAGCGTCTGCATAGCGGAGAGAAGCCCTTCCAGTGCTCCAAGTGCCTGAAACGTTTCTCGCATTCGGGAAGCTACAGCCAGCACATGAACCACCGTTACTCCTACTGCAAGCCGTACAGGGAATAG
Protein Sequence: MLSCLAPSSSRFGQEDNSIIQQSMPSSTAFTMQFPSLASSLHHHQAPHSKPINGSGGSQEQHAQPGVSVDDFLVKCTQCHKRFTEFQSLSEHIASEHPHDKLNFEASRGSSGAVQPESDAEDEQSNLSGSRYAKSPAATTHATPSNNNNNSDLAKNHNNNNNSNSSSSKLSPMCSPGSAGPTTAAADLFAHLSHGAPPQLPPHLHAQFMAAAALAMQSARSVSSSASSPSSHHHHQQHQQHQQQQQQQQSHLHHHQHQQQQQLHQQQSQQQLLPPQLPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDLSGAYPCMQCTAAFSSREQLEQHELLHSPTGGQPTAQNVSQTCRICHKAFANVYRLQRHMISHDESALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGLKLNNNRALLKRLEKSPGAAGPRRSPTDLQGPKNGAGKMSDQQSLPPLPNPMIYFAGEAQAQAAAANGAPPPFYPNYMNAALLAFPNPFMAAALDPRVHPYSIQRLLELTAAGQQQQHQQQQREEREEQEQDQHEEPETPEEPKLVMDIDESEAKERMVPQASPQTMPEEIEPVVDMAVAPIKQEPSREPTPLPESAPPSPKSFKQEQEEPRSVEEDQPMESAQPEASVSSPRVDTPAELRCSRCDKQFNHHTELVQHEKVLCGLIKEELEQHYHQQHQQQQHHQHLQQQQQAAFVLPSASEDDDEEEERENDNDTEPRQDSNERKVRVRTAINEEQQQQLKQHYALNARPSRDEFRMIAARLQLDPRVVQVWFQNNRSRERKMQSYANVHTAAPAANEVPTTPVASRPTTEDQPLDLSVKRDSLTPKSDHSAVYGLPQQQAAGQPAPADFQEAINLSRKFSSSASMSPASLSPSSGASLQQSSAAAAAAAAALWPFGGPPPSPPSQHEATPAQHCSTPRVSQAFPGLPYMMPMQRLPMEALFQMRPGGEYAPNPLMNSIKMPDFRGTSLSPGGSEKRSWRDDDSRISHEDDFGNGLMPPKGRRGKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00603548;
90% Identity: iTF_00563802;
80% Identity: iTF_00473681;