Basic Information

Gene Symbol
-
Assembly
GCA_009650485.1
Location
NC:12577139-12580011[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.063 3.8 7.8 5.9 3 23 273 293 271 293 0.96
2 12 0.0099 0.59 10.3 0.4 1 23 299 324 299 324 0.92
3 12 0.0043 0.26 11.4 0.7 2 23 332 356 331 356 0.93
4 12 0.00067 0.04 14.0 2.1 1 23 368 390 368 390 0.98
5 12 2.2e-06 0.00013 21.8 0.2 1 23 397 419 397 419 0.98
6 12 0.0062 0.37 10.9 0.1 1 23 425 447 425 447 0.98
7 12 0.006 0.36 11.0 4.0 1 23 453 476 453 476 0.98
8 12 0.0082 0.49 10.6 3.9 1 23 482 504 482 504 0.96
9 12 0.00014 0.0083 16.1 3.6 2 23 511 532 510 532 0.96
10 12 3.6e-05 0.0022 18.0 0.3 1 23 649 672 649 672 0.96
11 12 0.0096 0.57 10.3 1.2 1 19 678 696 678 700 0.94
12 12 1.6e-06 9.5e-05 22.2 4.1 1 23 706 728 706 728 0.99

Sequence Information

Coding Sequence
ATGAATGAAGGAGGGAGTGGATACTCCATACACACAATATGCCGCATCTGCTTAAACCTCCTGCAAAATGATGTCGCCTATGATTTGTTTCTGGTTCCGGGTCTGGCCaaaaagttgtgtgtgtgcacttcgCTTGCCGTGGAGCAACAAGACGGCTTCCCTATGAATCTGTGCACACAGTGCTTTAGCCGGCTCAATGATCTGCATGATTTTCAGAAGCTGTGCGTGGACTCGGTACAACGCTTTCAGCAGATGGTGGCCAACAATTTCTTTggagtaacagcaacaacagcagcagctgcaacaccgCTCAATCACATCGATAACTTTGATGTGCTGAATGTGGCTGGAGGAGCACAAGATGGGGAACTGGCTGGCGAGGAGGAGGATCGCATTAACTATGATCCGCTGCTCAATCACAAAATGGAGATCATTGAGAACGAGGAGGATGTGTTTAAAATGCTCGAACATGTCGATAAAGAGGCTGAAGAGGTTGAGAAAGAAGTCAAGGCTGATGTAGACGATCAGGCGGCGGGCATTATGCAAATGTTCGACGACGGTGACgatgtcgatgatgatgacgacggtGTTTCTTCTGCCGATGATCACGATGTGGACTTTGAGCCCAACAGCAGCGATGCTGACGATGATATGCCGCTGGCACAACGTCTGCGAGGCAATAAAATGAGCTCGCAAAAGCAAGTTGAAGATGTGGAGGATGAGGGCAGCTCCGAGTCGGATGAGGAAGGCGTCAAATCGAAGTCGAAACGCAAGCGTATTCCGGCGGCTGAGCGGCATCTGCATCGCATCATCGACTGCCACATCTGTCATCAAAAGTTCAAGAAAGCCATACGCTACGAGGAGCACATGAAGCACCACAACGATCTGCTTCCCTTCCAATGCAAAGTGGAGAGTTGCCGCAAGGGCTTCACTACAGCTGGCGGTCTGCGACTGCATGTGGATCATGCCCACACGGAGTTGTCCGAGGTTCATGCGTGCAGCGTTGAGGGCTGCGGCAAAACGTTTCCGCGCATACGTCTGCTCACCTTCCATATGAAAAAGGTGCACAATATTTCGAAAGCGGCAGCGCCGCCTCGTGATTATCCTTGCACCGAATGTGAGAAGATCTTCCGTTGTCCTATGGCGCTGAAGAAGCACATGTATAAGCACGATGGCAAGGAGCTACCGTTTCCCTGTAACATTTGTGGCAAACGCTTTGTGATCAACAGCGCCCTCAAGGATCATCTGATGCGGCATGCGGGCATCAAGAACTATGTGTGTCCCTATTGTGGCGTGGGTAAGACCACCCGACAGGAGTGGAACACACACATTCTGACACACACGCAGGAGAAGAAGTTCAAGTGCCATATATGTGAGCATGCGTCGCACAACAAACAGAGTCTGGCCAATCACATAAAGATTGTACACGAGAAGATCAAGAACTATGCGTGTCAATATTGTGGCAAGACCTTTGGCAAGTCGCATGCCTGCAAGATCCATGAGATGACGCACACTGGGGAGAAGCGTTGCGAGTGCAAGGTGTGTGGCAAAAAGTTCCTCTATCCAAAGAGCCTGACGAAGCATCTGAAGACGCACGAGAAGCGCGTGTTGCGGGCTATGGAAACGTATCGTCAGCGTCAGGTGGAACTGGGCGAAGGTGCtacagcaggagcagcagccactGAGAGCACGGACATCGCCGAAGTAGTTGGCTCACAAGCGCACAATCCCGCGGACGTCGTTGTCGATGGGCTGATGTCGCAGAATGCTGCTGATGAACTGTTGAAAGTGTGCGCCGAATCGGTGGCCACAATACCTAAGGATCCGCGTCGTGTGCAACGTGTGGACATTTCACAGCTGGCTGGCACCGCTGTCAATCCCATACCCTCAGTTTCGGTGCCGTCGTGGTCACCTCAAGTCAACTTCACCAAGAAGGAAGGCAAACACATTTGTCCGGGTTGCGGTCAAGGCTTCAACAACATTGGCAACATGAAACGTCACTATAAGATCATACACGAGAAGGTCAAGGATTTCGCCTGTCGGTTTTGTCCAAAGCGTTTCGCCAAGGCGCAAACGCTGCGACACCACGAATGGATTCATACGGGCGAGAAGCCCTTTGAGTGCAAGACGTGTGGCACACACTTCCGCCAGGAGACGGCGCTGAAGCGACATCAGCGCACGCACGAGAATCGCCCGCCTGTCATCTCATCCAAGTTCTATGCGGCACGCGAAGAACTGGAGGAGCAGGAGCGTATGAAACGTGAGGCGCGTCGCAAGGCGGATGCGAAGCGTAAAGAGATTGCCGAGGCGGCTAAGGAGCAGCTGTCGTCGCTGCACAAACTGGAGGCAACCGACAAGAATCTGCACTCGTACGACGAGTATCAAGAGGCAGCTGCGGAGCGTGCGGCTGCCTCGGCTGAGCTGCAGGCACAGCAGTACGAGGAGAACGAGGTGAAACGGCGAGCGGACATGGAGCGTCGCAAGATCCAGGAAGCAGCGTACGAGCAGCTGCagaaactgcagcagcagcaggagatcGAGAAGGCGCAAAGCTCCTACGATGGCTACTATGCGCAAAAGGCGCATGCCGAAGGCACCTCAATCGATGACCTCAAGATTGATCATGTGTGA
Protein Sequence
MNEGGSGYSIHTICRICLNLLQNDVAYDLFLVPGLAKKLCVCTSLAVEQQDGFPMNLCTQCFSRLNDLHDFQKLCVDSVQRFQQMVANNFFGVTATTAAAATPLNHIDNFDVLNVAGGAQDGELAGEEEDRINYDPLLNHKMEIIENEEDVFKMLEHVDKEAEEVEKEVKADVDDQAAGIMQMFDDGDDVDDDDDGVSSADDHDVDFEPNSSDADDDMPLAQRLRGNKMSSQKQVEDVEDEGSSESDEEGVKSKSKRKRIPAAERHLHRIIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCKVESCRKGFTTAGGLRLHVDHAHTELSEVHACSVEGCGKTFPRIRLLTFHMKKVHNISKAAAPPRDYPCTECEKIFRCPMALKKHMYKHDGKELPFPCNICGKRFVINSALKDHLMRHAGIKNYVCPYCGVGKTTRQEWNTHILTHTQEKKFKCHICEHASHNKQSLANHIKIVHEKIKNYACQYCGKTFGKSHACKIHEMTHTGEKRCECKVCGKKFLYPKSLTKHLKTHEKRVLRAMETYRQRQVELGEGATAGAAATESTDIAEVVGSQAHNPADVVVDGLMSQNAADELLKVCAESVATIPKDPRRVQRVDISQLAGTAVNPIPSVSVPSWSPQVNFTKKEGKHICPGCGQGFNNIGNMKRHYKIIHEKVKDFACRFCPKRFAKAQTLRHHEWIHTGEKPFECKTCGTHFRQETALKRHQRTHENRPPVISSKFYAAREELEEQERMKREARRKADAKRKEIAEAAKEQLSSLHKLEATDKNLHSYDEYQEAAAERAAASAELQAQQYEENEVKRRADMERRKIQEAAYEQLQKLQQQQEIEKAQSSYDGYYAQKAHAEGTSIDDLKIDHV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00575777;
90% Identity
iTF_00553862;
80% Identity
-