Basic Information

Insect: Drosophila affinis
Gene Symbol: -
Assembly: GCA_037356375.1
Location: CM074802.1:5419173-5421326[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.015 1.3 10.0 1.7 3 23 286 307 284 307 0.95

2 8 0.00078 0.065 14.0 1.5 1 23 370 392 370 392 0.97

3 8 8.5e-06 0.00071 20.2 1.0 2 23 400 422 400 422 0.96

4 8 0.00016 0.013 16.2 0.7 3 23 431 452 429 452 0.93

5 8 0.013 1.1 10.2 0.3 2 23 461 482 460 482 0.97

6 8 0.029 2.4 9.1 1.6 1 23 491 513 491 514 0.96

7 8 0.00046 0.038 14.8 0.4 1 23 519 541 519 541 0.98

8 8 0.046 3.8 8.5 7.1 1 23 547 570 547 570 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.015	1.3	10.0	1.7	3	23	286	307	284	307	0.95
2	8	0.00078	0.065	14.0	1.5	1	23	370	392	370	392	0.97
3	8	8.5e-06	0.00071	20.2	1.0	2	23	400	422	400	422	0.96
4	8	0.00016	0.013	16.2	0.7	3	23	431	452	429	452	0.93
5	8	0.013	1.1	10.2	0.3	2	23	461	482	460	482	0.97
6	8	0.029	2.4	9.1	1.6	1	23	491	513	491	514	0.96
7	8	0.00046	0.038	14.8	0.4	1	23	519	541	519	541	0.98
8	8	0.046	3.8	8.5	7.1	1	23	547	570	547	570	0.97

Sequence Information

Coding Sequence: aTGATGATATGTCGACTCTGCCTGGAGGATACAGAGCACAGTGTGCCCATCTTCGATCAGGATGAAGAACCGGTGCCTCAAACGGTGCAGCATCTGGCGAAACTGATAGAGAAGCATCTTCAGCTGGTGCTTGCGGCCAATGATGCCGTGTCCACTTGCCTGTGTGGCACATGCTGGCAGCAGCTATCCAGCTTTGAGCAGTTTTGCGCCATGGTGGCGGACAAGCAACGCGCATTGCAGCTTAAGATCGAGCTCTCAGATCCAGAGCCGGAACCAGGTCTCATCGTGTGGAATACTGAGTCTCCTATCGAGTCGAAGATCGATTTCGATGGCGGTGATGTTAAGGACCACATTTTGTGTGAGCCCGTCATCGACGCAATGGCCGCCAGAGACGATAATGCGGATGATAGTGACGATGGCGACCGATTTGAGACGGACTTCGAGCCCAATGCCATCGAGCCAGATCCTGTAAAACCTAAACCAGgtaggggcagaggcaggcccCGTAAAACTCTCAAAACAGATTCCCAGCTCATAAAAAAGAAATACGAGAAGCACAAACAGACGAGGGCGGGCCTCACTGGACTTACACTTCGCGAGTCCCGGTCACGTGCCCGCGAACTTAGACGTAGACCTGAGGCTGTATCATCAGACAACGACTCGAAACCTGCGGAAAACATTCCCAGCGTGCCGATCCGGAGCAGCGGAAATCGTGGCCGTCCGAAGACTATGACTAAGTGCAAGAGAAAGACTCCAACTGTTGTGGTGGCACCTAAAACTGACACTGAACCTGCTGTGAAGCGAAACAGCATCCAGGAGATGGACGAGTTTATAGCGGCCAATGTGAAGCTCGATTGTTGCCTGTGCGGGACTCCCCTTAAGGACTTTAACGATCTGAAGCGACACTTTCGATCGGAGCACAATGTCTTGGGATACGTGAAGTGCTGCAACAATCGGTATAAGAAGCGTACTCTGTACGTGGACCACCTACACTGCCACAAGGACCCGCAGTATTTCAGCTGTCAGCCCTGCCGCAAGAACTTCCTGAATCGCAACAGCCAGGTCATGCACATGCTGCGCTTTCACTCCGAACAGCAGGAGCTGGTGCATCAGTGCTCCATCTGCGAGGCACGGTTTGCCAAGAAATTCCTGCTGACCATGCATCTGAAAGGACACAAGGGCACCGAGCGTCCCGAGGTTTGCGACACATGTGGCAAGACATTCCGCACCAAATTCGAGCTGAGCGCTCACGAGAAGCGAATGCACGCGGCGGACTTCACCCCCATCATCTGTGACATCTGTGGCACGCATTTCCGTTCAAAGGCCAACTTTCTCATCCACAAGAAGGCACTGCATCCGGATGGGCCCGTGGCGGAAGTGCAGTGTACCCTGTGCGGCCGCTGGCTGCGGGATGAGCGGAGTCTCCGCAAGCATCTGGCACGACATGATGATCGCGACAATGAGAACAAGTATCGCTGTTCGCTGTGCAACGCGGAGAAGTCCTCTCGTGCCGCACTCAGCAGCCACATGAGGTACCATCACTCTGCCAAGCGGCACAAGTGCAGCCTCTGTGCCAAGGAGTTCAAACTGCCTCGTGCTCTGGTTGAGCACATGGCCACGCACACCGGAATCGATCTGTACTCGTGTCAGTTCTGCGCTCGCACTTTCAAGTCGCACGCTAACATGCACAACCACAAGAAGAAGATGCATCCAAATGAGTGGGTGCGAAAGTATTCACAGCCCACAACTAGTTCCGCTTTGGGTTCCTCCTCAGGCCATCTCACCAGtacagaggcggaggcagagacGAAGGCTGTGACTGATGCGAATCTTTTGGGGCCGGCCACCAACTTAATGGATGACCCATCCGTTGTAGAGACCTTTGAGCTGCTTAGCAACAGCTCCACATGCCCCACGCTCGACTGA
Protein Sequence: MMICRLCLEDTEHSVPIFDQDEEPVPQTVQHLAKLIEKHLQLVLAANDAVSTCLCGTCWQQLSSFEQFCAMVADKQRALQLKIELSDPEPEPGLIVWNTESPIESKIDFDGGDVKDHILCEPVIDAMAARDDNADDSDDGDRFETDFEPNAIEPDPVKPKPGRGRGRPRKTLKTDSQLIKKKYEKHKQTRAGLTGLTLRESRSRARELRRRPEAVSSDNDSKPAENIPSVPIRSSGNRGRPKTMTKCKRKTPTVVVAPKTDTEPAVKRNSIQEMDEFIAANVKLDCCLCGTPLKDFNDLKRHFRSEHNVLGYVKCCNNRYKKRTLYVDHLHCHKDPQYFSCQPCRKNFLNRNSQVMHMLRFHSEQQELVHQCSICEARFAKKFLLTMHLKGHKGTERPEVCDTCGKTFRTKFELSAHEKRMHAADFTPIICDICGTHFRSKANFLIHKKALHPDGPVAEVQCTLCGRWLRDERSLRKHLARHDDRDNENKYRCSLCNAEKSSRAALSSHMRYHHSAKRHKCSLCAKEFKLPRALVEHMATHTGIDLYSCQFCARTFKSHANMHNHKKKMHPNEWVRKYSQPTTSSALGSSSGHLTSTEAEAETKAVTDANLLGPATNLMDDPSVVETFELLSNSSTCPTLD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00603665;
90% Identity: iTF_00518023;
80% Identity: -