Basic Information

Gene Symbol
-
Assembly
GCA_037356375.1
Location
CM074799.1:11053450-11063459[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 0.43 35 5.4 1.8 1 23 691 713 691 713 0.96
2 7 1.7e-05 0.0014 19.3 1.1 1 23 719 741 719 741 0.98
3 7 7.3e-06 0.00061 20.4 0.2 1 23 747 769 747 769 0.98
4 7 3.4e-06 0.00028 21.5 1.4 1 23 775 797 775 797 0.98
5 7 0.00079 0.066 14.0 1.7 1 23 803 825 803 825 0.98
6 7 5e-06 0.00042 20.9 2.4 3 23 833 853 831 853 0.94
7 7 3.9e-05 0.0032 18.1 3.4 1 23 859 882 859 882 0.98

Sequence Information

Coding Sequence
ATGTTGCCGCTGCAGGAGCAagtgcagcagccacaacccCAGCCCTTTAATTGGCAACTGGAGGATTACGCCTACTTTCGAAAATGTGGAGAGCTTACCACATCGCCGGATGTGCAGAGCTTTGGCTTCAATTGCGCCTTCTGCCCTGCAATTTGCCTGCAGTTCTCGGTGTTTATGGATCACATTCGCAGCCAGCACATTCAGGACGTGAGACGACGGTATGAGGACTCCGAGGATACAATCGAACAAACAACACAAACTGATTTAATGATAATGGAAATGGACTGCCATGACATATTCCAACTGGAAGACCAAGACCAGACCACAGCCAACAAATGCACTAAGAAATCGAATTTGAGTGGGCTAGAGATTGAGGCGGAACCGGAATCCACGATAGCGGCAGACACGCAACGCCTGGGGGTGATAGACATGGACATTCAGCTAATGAATATAGTCGCGGCGACCCCCACAATGCAGCTATCCCATGCAGTGGGAACACCCGAAATAGATTTGGTCTATGTTATGGAAAATCCATTGCCACCCTCACCGCCACCATCCGCGGACATTTCGGGTGACGAGCAGACCTGCCTGCAGGCACTGGGCCCGTTTGAAGTGCTTCATGAAGTGGTGGGCATGGTCACGCCTACGCCGACGCCCTCACCTTTGGCTGGGATTGGCGCTAGCGTTGGGGTCGCTCCACTTCCACCGCCGCGATACGAGACACGACGCGTGGCAATGCAGCGCAAGCTTCGTCAGGCGGAAAACGAGAATGCAAAAGATTTCAGCCggcaagaggcagaggcagcggcagcggcagagagagaccCAGAGACGGGAGTGGCAGATGCAGCGCAATTCTCCACCGAAAACGTGTCGGAGCTGACACCGCCTGCGACGCCGCCAACCCCAGGGCCGCCCACATCCCCCACGAGCAGCATTGGCAGCAACGCGGACTTCCAGGCGCGAACTCGTCGCGAGCTGGAACGCAATCGGGAATTCGTTGGCTCTCTGCTGGCAGCCTACGAGCGCATGGAAAAGCTGTGGAATCCACGGCATCCCGACTACAAGTACAATGCCAAGCGAAGTGTGTACGGAGAGCTGGCGGCCCCGCTGGAGGGCATCTGCCAGATGCAGCTGACGGGCGTGGAAATCTTTGCCGTGCTCAAGGAGCTGCGTGGCCGCTATCGCCGGGAGCTGAGCAAGCTGAATGCCCTCGGGGGCAAGTACAAGTCCCGCCTGTGGTACTTTGACAAGATGCACTTCCTCAGAGGCGTCATCGAGAACAAGCGGGCCGAAAGGGAAGCCAAGCTCACCAATGATAGCACCGAAAGCGAAAAGTCCTGCGAAACCGATGGCGAGTCGTGCAGCAAGTCTGCCCTGTACCGTGAGGTGCTCAGCTTCATACTGGATGCGTTCAAGCGGCTGGAGTGTCTGTGGAATCCGCAGCACTACGAGTACGCCAGCTGCTGCAAGAAGGAGCTGTACCGGGAGATCTCCGCCCAGCTGCAGGAGGAGCTCAGCTACGAGCTGAGTGGCGAGGAGTGCCACAAGGAGATACAGAAGCTGAGGACGCGCTACCGCAAGGAGCTGCGCATGGTGATCAAGCACAAGGGCCTGTATCTGCCCAAGCTCTGGTGCTACGACGAGATGGAGTTCCTGCAGCCGATACTGCAGGAACAGATCTTCAATAAGATCAGCAAGAAAGTCGGTGTGGTGGAGACCAACCAGAAGACGAAGTTCATCGATGCCAGCTCCATTGAGTTCGGAACGGCGGAGGATCAGCTGCAGTTCGTGGAGATATATCGCAACTACGCGGCGTTGTGGGATGTGGATCATCCCGACTTCAGATCGAATGCCTACCGCAGTCAGGCGCTGACCCAGATGCTGGACGAGCTGAACGCAACCTTCCACACGGCATATGCCGCGGAGCAGCTGGAGAAGACCCTGTTCGAGCTGCGCAAGGAGTTCTCAGCGCAGAAACGAAAAATACTCACCAGCCCAGGGGACGCGTGCAGCATTCCCCTGCTGCACGCGAGACTGGCAGACTTTCTGGAACAGAATCTGGGTCCCTTCCGCTGCGATGTCTGCTCGGAGCTCATCAAGACCTGCGACCAGTACAAGGTGCATCGGTCCGGGCACGACGGCACCCCGCCCTTCATTTGCACGCTCTGCGGCAAGGGCTTCCAGATGCCGTGCAACCTGACCGTGCACATTCGACGGCATCGTCGCGACTTTCCCTATGCGTGCGAGAAGTGCGACAAGCGCTTTGCCACATCCACTGAGGTGGCCATCCACCTGCGGACGCACACTGGGGAGCGGCCCTACATCTGCGACCTGTGTGGGAAGTCCTTCAAGACGTGGTCCTTCTTCGACATCCATCGGCGCAGGCACCTCAACCAGTCGACATTCAGCTGCACCATCTGCGAGAAGGGGTTCTACGAGAAGAACCGCTTCACCGACCACATGAACTCCCACTGGGCCATACGCAAGCACCTGTGCACGGTGTGCGGCAAGACCTTCACCACCTACGGAAACCTCAAGAAGCACACCGAACTGCATTTGGCCGTGAAGAAGTACAAGTGCTGCACGTGCGGCAAACGCTTCGCCCAGTTCGCCAGTCTGCGCTGGCACAGAAAGCGGGCACACGGCTCCGGGCAATCGGAGGAGAAGTAG
Protein Sequence
MLPLQEQVQQPQPQPFNWQLEDYAYFRKCGELTTSPDVQSFGFNCAFCPAICLQFSVFMDHIRSQHIQDVRRRYEDSEDTIEQTTQTDLMIMEMDCHDIFQLEDQDQTTANKCTKKSNLSGLEIEAEPESTIAADTQRLGVIDMDIQLMNIVAATPTMQLSHAVGTPEIDLVYVMENPLPPSPPPSADISGDEQTCLQALGPFEVLHEVVGMVTPTPTPSPLAGIGASVGVAPLPPPRYETRRVAMQRKLRQAENENAKDFSRQEAEAAAAAERDPETGVADAAQFSTENVSELTPPATPPTPGPPTSPTSSIGSNADFQARTRRELERNREFVGSLLAAYERMEKLWNPRHPDYKYNAKRSVYGELAAPLEGICQMQLTGVEIFAVLKELRGRYRRELSKLNALGGKYKSRLWYFDKMHFLRGVIENKRAEREAKLTNDSTESEKSCETDGESCSKSALYREVLSFILDAFKRLECLWNPQHYEYASCCKKELYREISAQLQEELSYELSGEECHKEIQKLRTRYRKELRMVIKHKGLYLPKLWCYDEMEFLQPILQEQIFNKISKKVGVVETNQKTKFIDASSIEFGTAEDQLQFVEIYRNYAALWDVDHPDFRSNAYRSQALTQMLDELNATFHTAYAAEQLEKTLFELRKEFSAQKRKILTSPGDACSIPLLHARLADFLEQNLGPFRCDVCSELIKTCDQYKVHRSGHDGTPPFICTLCGKGFQMPCNLTVHIRRHRRDFPYACEKCDKRFATSTEVAIHLRTHTGERPYICDLCGKSFKTWSFFDIHRRRHLNQSTFSCTICEKGFYEKNRFTDHMNSHWAIRKHLCTVCGKTFTTYGNLKKHTELHLAVKKYKCCTCGKRFAQFASLRWHRKRAHGSGQSEEK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00484618;
90% Identity
iTF_00487502;
80% Identity
-