Basic Information

Insect: Drosophila affinis
Gene Symbol: zfh1
Assembly: GCA_037356375.1
Location: JAZHFB010000003.1:38694701-38719728[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.003 0.25 12.2 1.9 2 23 75 97 74 97 0.95

2 9 0.0022 0.18 12.6 0.1 1 23 310 332 310 332 0.96

3 9 0.00012 0.01 16.6 1.7 2 23 347 368 346 368 0.97

4 9 5.8e-06 0.00049 20.7 6.3 1 23 377 399 377 399 0.99

5 9 0.00035 0.029 15.1 1.2 3 21 407 425 405 426 0.94

6 9 0.0098 0.81 10.6 1.8 2 21 674 693 673 694 0.92

7 9 1.6e-05 0.0013 19.4 0.5 1 23 1056 1078 1056 1078 0.94

8 9 5.8e-05 0.0048 17.6 7.4 1 23 1084 1106 1084 1106 0.98

9 9 0.0029 0.24 12.2 4.3 1 21 1112 1132 1112 1133 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.003	0.25	12.2	1.9	2	23	75	97	74	97	0.95
2	9	0.0022	0.18	12.6	0.1	1	23	310	332	310	332	0.96
3	9	0.00012	0.01	16.6	1.7	2	23	347	368	346	368	0.97
4	9	5.8e-06	0.00049	20.7	6.3	1	23	377	399	377	399	0.99
5	9	0.00035	0.029	15.1	1.2	3	21	407	425	405	426	0.94
6	9	0.0098	0.81	10.6	1.8	2	21	674	693	673	694	0.92
7	9	1.6e-05	0.0013	19.4	0.5	1	23	1056	1078	1056	1078	0.94
8	9	5.8e-05	0.0048	17.6	7.4	1	23	1084	1106	1084	1106	0.98
9	9	0.0029	0.24	12.2	4.3	1	21	1112	1132	1112	1133	0.96

Sequence Information

Coding Sequence: ATGTTGTCCTGCCTGGCGCCGTCGTCTTCACGTTTTGGCCAAGAGGATAACAGCATCATACAGCAGAGCATGCCATCGTCCACAGCCTTCACCATGCAGTTTCCCTCTTTGGCTTCCAGTCTGCACCACCACCAGGCACCGCACAGCAAGTCGATCAATGGCTCCGGTGGCAGCCAGGAGCAGCACGCACAGCCAGGTGTATCGGTCGATGATTTCCTGGTCAAGTGCACGCAGTGCCACAAACGCTTCACAGAGTTTCAGTCCCTCAGCGAACACATTGCCAGCGAGCATCCGCACGATAAGCTGAACTTTGAGGCAAGTCGTGGCTCCAGCGGTGCCGTGCAGCCGGAGAGCGATGCCGAGGACGAGCAGAGCAATCTGAGTGGCAGCCGATATGCCAAGTCCCCTGCCGCCACCACCCATGCCACgcccagcaacaacaacaacaacagcgatcTGGCCAagaaccacaacaacaacaacaacaacaacagcaacagcagcagcagtaagcTCTCGCCGATGTGCTCTCCCGGCTCGGCGGGtcccaccaccgccgccgcagATCTCTTCGCCCACCTCTCACACGGAGCCCCGCCCCAGCTGCCCCCCCACCTGCACGCCCAGTTcatggccgccgccgccctgGCCATGCAATCGGCCCGCTCCGTCAGCTCTTCCGCCAGTTCGCCCAACagccaccatcaccaccagcagcagcaacagcagcagcagtcgcaccttcatcatcaccagcagcagcagcaccagcagctccaccagcagcaggcgcagcagcagctgctgccgccccAGCTACcgggcagcaacagcagcgtgggcagcaaTTCCGCCTACGACCTGGACCTGAGTGCCCCGCGCTCCACCTCCAGTCCGGGCTCCACCACCGGCGACCTGAGCGGCGCCTATCCCTGCATGCAATGCACCGCCGCCTTCAGCAGCCGCGAACAGCTGGAGCAGCACGAGCTCCTCCACTCGCCCACCGGGGGCCAGCCCACGGCACAGAATGTCTCTCAGACCTGCCGAATCTGCCACAAAGCCTTCGCGAATGTCTACCGCCTGCAACGGCACATGATCAGCCACGACGAGTCGGCGCTACTGCGCAAATTCAAGTGCAAGGAGTGCGACAAGGCCTTCAAATTCAAGCACCACCTGAAGGAGCATGTGCGCATCCATTCCGGCGAGAAGCCCTTCGGCTGCGACAACTGCGGCAAGCGATTCTCGCACTCCGGCAGCTTCTCCTCCCACATGACCTCCAAGAAGTGCATCAGCATGGGCCTCAAGCTGAACAACAATCGGGCGCTGCTCAAGCGTCTGGAGAAGAGTCCTGGCGCCACCGGTCCCCGGCGCTCGCCCACGGACCTGCAGGGCCCCAAAAACAGTGCTGGAAAGATATCCGATCAGCAGTCCCTGCCACCACTGCCCAATCCCATGATCTACTTTGCCGGCGAGGCCCAGGCGCAAGCTGCGGCCGCGAATGGAGCTCCTCCACCGTTCTATCCCAACTACATGAATGCGGCCCTGCTGGCCTTTCCCAATCCCTTCATGGCAGCGGCCCTGGATCCGCGCGTCCATCCGTACAGCATACAGCGTCTCCTAGAGCTGACTGCCGccggacagcagcaacaacatcagcagcagcaacgcgaGGAACGcgaagagcaggagcaggatcaGCACGAAGAGCCTGAGACGCCGGAGGAGCCCAAGCTGGTCATGGACATCGATGAGTCTGAGGCCAAGGAACGTATGGTGCCACAGGCAAGCCCTCAGATTGTGCCAGAGGAGATCGAACCCGTTGTCGACATGGCCGTTGCTCCCATAAAGCAGGAGCCCAGCCGCGAGCCCACCCCACTCCCGGAGAGTGCACCGCCCTCGCCCAAGTCTTTCAAGCAGGAGCATGAGGAGCCCCGTTCCGTAGAGGAGGATCAGCCCATGGAATCGGCTCAGCCCGAAGTCTCTGTCTCCTCCCCCAGGGTGGACACACCGGCCGAGCTGCGTTGCAGCCGCTGTGACAAGCAGTTCAACCACCACACGGAGCTGGTGCAGCACGAGAAGGTCCTCTGCGGCCTGATCAAGGAGGAGCTCGAGCAGCActaccaccagcagcagcagcaacaacagcaccaccaacatctccagcaacagcagcatcagcaacaggcTGCCTTTGCCATGCCCTCTGCCAGCGAGGATgatgacgaggaggaggagcgggaGAACGACAACGACACGGAGCCACGTCAAGACAGCAACGAGCGCAAGGTGCGCGTGCGCACAGCCATCaacgaggagcaacaacagcagctgaAGCAGCACTACGCCCTCAATGCGCGGCCGAGTCGCGACGAGTTCCGTATGATTGCGGCCCGTCTTCAGCTGGATCCGCGCGTGGTCCAGGTCTGGTTCCAGAACAATCGGTCACGCGAGCGCAAGATGCAGAGCTATGCGAATGTCCACACTGCAGCTCCAGCCGCCAATGAAGTGCCCACCACTCCAGTGGCCAGCCGTCCCACGACCGAGGATCAGCCCCTGGATCTGTCGGTGAAGCGCGACTCCTTGACGCCCAAGAGCGACCACTCCGCCGTGTACGGAttgccccagcagcaggctgCCGGACAGCCAGCCCCCGCCGACTTCCAGGAGGCCATCAACCTGAGCCGCAAGTTCTCCAGCTCGGCCTCCATGTCGCCAGCCTCGCTGTCGCCCTCGTCGGGCGCCTCTCTGCAGCAATCCTCGGCAGCTgcggccgccgctgctgcagccctCTGGCCCTTTGGCGGCCCGCCTCCGTCGCCCCCCAGCCAGCACGAGGCCACGCCCGCCCAGCACTGCTCGACGCCGCGTGCTGGCCAGGCCTTCCCTGGACTACCGTACATGCTGCCCATGCAGCGGCTTCCCATGGAGGCCCTCTTCCAGATGCGCCCTGGCGGCGAGTACGCCCCCAATCCCCTGATGAACAGTATTAAGATGCCCGACTTTCGCGGCACCAGTCTCAGTCCGGGCGGCTCCGAGAAGCGCTCCTGGCGGGACGACGACTCGCGCATCTCCCACGAGGACGACTTCGGCAACGGCCTGATGCCGCCCAAGGGCCGTCGTGGCAAGGCCGAGACCCACGGGCATGCCGGCGATCCGGATCTGCCCTTTGTCTGCGACCAGTGCGACAAGGCGTTCGCCAAGCAGAGCTCCCTGGCGAGGCACAAGTACGAGCATTCCGGTCAAAGACCCTACCAGTGCATGGACTGCCCGAAGGCCTTCAAGCACAAGCACCACCTGACGGAGCATAAGCGTCTGCATAGCGGAGAGAAGCCCTTCCAGTGCTCCAAGTGCCTAAAACGTTTCTCGCATTCGGGAAGCTACAGCCAGCACATGAACCACCGTTACTCCTACTGCAAGCCGTACAGGGAATAG
Protein Sequence: MLSCLAPSSSRFGQEDNSIIQQSMPSSTAFTMQFPSLASSLHHHQAPHSKSINGSGGSQEQHAQPGVSVDDFLVKCTQCHKRFTEFQSLSEHIASEHPHDKLNFEASRGSSGAVQPESDAEDEQSNLSGSRYAKSPAATTHATPSNNNNNSDLAKNHNNNNNNNSNSSSSKLSPMCSPGSAGPTTAAADLFAHLSHGAPPQLPPHLHAQFMAAAALAMQSARSVSSSASSPNSHHHHQQQQQQQQSHLHHHQQQQHQQLHQQQAQQQLLPPQLPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDLSGAYPCMQCTAAFSSREQLEQHELLHSPTGGQPTAQNVSQTCRICHKAFANVYRLQRHMISHDESALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGLKLNNNRALLKRLEKSPGATGPRRSPTDLQGPKNSAGKISDQQSLPPLPNPMIYFAGEAQAQAAAANGAPPPFYPNYMNAALLAFPNPFMAAALDPRVHPYSIQRLLELTAAGQQQQHQQQQREEREEQEQDQHEEPETPEEPKLVMDIDESEAKERMVPQASPQIVPEEIEPVVDMAVAPIKQEPSREPTPLPESAPPSPKSFKQEHEEPRSVEEDQPMESAQPEVSVSSPRVDTPAELRCSRCDKQFNHHTELVQHEKVLCGLIKEELEQHYHQQQQQQQHHQHLQQQQHQQQAAFAMPSASEDDDEEEERENDNDTEPRQDSNERKVRVRTAINEEQQQQLKQHYALNARPSRDEFRMIAARLQLDPRVVQVWFQNNRSRERKMQSYANVHTAAPAANEVPTTPVASRPTTEDQPLDLSVKRDSLTPKSDHSAVYGLPQQQAAGQPAPADFQEAINLSRKFSSSASMSPASLSPSSGASLQQSSAAAAAAAAALWPFGGPPPSPPSQHEATPAQHCSTPRAGQAFPGLPYMLPMQRLPMEALFQMRPGGEYAPNPLMNSIKMPDFRGTSLSPGGSEKRSWRDDDSRISHEDDFGNGLMPPKGRRGKAETHGHAGDPDLPFVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00603548;
90% Identity: iTF_00563802;
80% Identity: iTF_00471511;