Basic Information

Insect: Drosophila affinis
Gene Symbol: -
Assembly: GCA_037356375.1
Location: CM074802.1:43483405-43485723[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 12 0.067 5.6 7.9 5.9 3 23 253 273 251 273 0.96

2 12 0.0065 0.54 11.1 0.6 1 23 279 304 279 304 0.93

3 12 0.001 0.086 13.6 0.8 1 23 311 336 311 336 0.95

4 12 5.6e-05 0.0046 17.6 2.5 1 23 345 367 345 367 0.97

5 12 9e-05 0.0075 17.0 0.1 1 23 374 396 374 396 0.97

6 12 0.0073 0.6 11.0 0.5 1 23 402 424 402 424 0.97

7 12 0.072 6 7.8 2.1 1 23 430 453 430 453 0.97

8 12 0.012 0.99 10.3 4.5 1 23 459 481 459 481 0.96

9 12 0.00033 0.027 15.2 2.4 2 23 488 509 487 509 0.96

10 12 1.6e-05 0.0013 19.3 1.9 1 23 585 608 585 608 0.96

11 12 0.043 3.6 8.6 7.1 1 23 614 636 614 636 0.94

12 12 3.5e-06 0.00029 21.4 2.3 1 23 642 664 642 664 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	12	0.067	5.6	7.9	5.9	3	23	253	273	251	273	0.96
2	12	0.0065	0.54	11.1	0.6	1	23	279	304	279	304	0.93
3	12	0.001	0.086	13.6	0.8	1	23	311	336	311	336	0.95
4	12	5.6e-05	0.0046	17.6	2.5	1	23	345	367	345	367	0.97
5	12	9e-05	0.0075	17.0	0.1	1	23	374	396	374	396	0.97
6	12	0.0073	0.6	11.0	0.5	1	23	402	424	402	424	0.97
7	12	0.072	6	7.8	2.1	1	23	430	453	430	453	0.97
8	12	0.012	0.99	10.3	4.5	1	23	459	481	459	481	0.96
9	12	0.00033	0.027	15.2	2.4	2	23	488	509	487	509	0.96
10	12	1.6e-05	0.0013	19.3	1.9	1	23	585	608	585	608	0.96
11	12	0.043	3.6	8.6	7.1	1	23	614	636	614	636	0.94
12	12	3.5e-06	0.00029	21.4	2.3	1	23	642	664	642	664	0.99

Sequence Information

Coding Sequence: atgaaCGAGGGGAGTCAGTACTCCATACATACGGTATGCCGCACATGTCTGAGCACCCTGCACGACACAATGGCGTACGATCTCTTTTTGATTCCGGGCCTGGCCAAAAAACTATGCGTGTGCACTTCGCTATCGGTGGAGCAGCAGGATGGCTTTCCCAAGAACCTGTGCTTCAACTGCTACGCGAAGCTGAACGAGCTGCACGACTTCCAGAAGCTGTGTGTGGACTCGGTGCAGAAATTCCAGGATCTGGTCTCCAGCAATGCCTTCACGTGCCAGACGAACTTCGATGTTCTGGATCCCAGTGCTGCAGTCGCAGACCTGCCGCCCGACGACGAGGACCACGTCAACTTTGATCCGCTTTTGAATTCCAAGATAGAGATCATTGAGAATGAGGAGGATGTGTTCAAAATGCTGGAAGATGTGGAGAAGGAGGTCGAGGAGGTAGAGAAAGATGAGCTCGGCTCTGCCGAGGAATCCAACGACTCTTCCGTTGAGagcggcaacgacaacgaccaGGACGAGGATTTCCAGCTAAACAGCAGCGATGATGACGTGCCCCTGGCCCAACGGGCCCGACGCGGAAACAGGCGTGGACCCAAAGCCAAGGCCAGCAAACGACCCGTAAAGGAAGATTCGGACGAATTCAGCTCCTTCTCCGACGACTCGGACTCGGATGGCGAGAAGGGCGGTAGGGAGAAGCCCAAGCGCAAAAGGATTCCCGCAGCCGAGCGACACCTCCATCGCCTCATCGACTGCCACATTTGTCATCAGAAGTTCAAGAAGGCCATTCGCTACGAAGAGCACATGAAACACCACAACGATCTCCTCCCCTTCCAGTGCAAGGTGGAGAGCTGCCGGAAGGGATTCACAACGGCCAACGGTCTGCGCGTCCATGTAGAGCATGCCCACACAGAGTCATCGGAAATGCATCCGTGCACCTACGAGGGCTGCAACAAATCCTTTGCCCGGCCCGTGCTGCTCAATTTCCACATGAAGCGAGTGCACAAGGTGGACACGCCCCAGAGGGACTTCCCGTGCACGGAATGCGACAAAGTATTCCGCTGCCCCACGGCCCTCAAGAAGCACATGTACAAGCACACGGGCGAGGAGCTGCCATTCGCCTGTGAGATCTGCGGCAAGCGATTCCCCATCAACAGTGTGCTGAGGGATCACTTGCTGCGGCATGCGGGCATCAAGAACCACGTCTGTCCGTACTGCGGCGTGGGCAAGACCACGCGCCAGGAGTGGAACAAGCACATTCTCACCCACACCAAGGAGAAGAAGTACGAGTGCCGCCAGTGCGAGCACACCTCGCACAACAAGCAGGCCCTGGCCAACCACGTCAAGGTGGTGCACGAGAAGAGGAAGGATTTCGCCTGCCAGTATTGCGGAAAGACCTTCGGCAAGTCGCATGCCTGCAAGATCCATGAGAGAAGCCACACAGGAGAGAAGTGCTGCGAGTGCAAGATCTGCGGCAAGGTCTTCCTCTTCGAGAAGGGCCTCACCAAGCATTTAAAGACGCACGAAAAGTCGGATCTGCCCAGGAACCAGACCACAGTCAATCCATTACTGGCCGAGGTCGCTGCGGCATCCTCCTCCTCAACCATTGCGAAGCCCAGCCCTCACTTGCGTGGGCGTGTGGAAAGAGTAGACATTGCTCAGTTGGCAGGCACTGTGGTGAATCCCATACCGTCTGTTAACCTACCGTCGTGGTCGCCGCAGGTGAACTTTACCAAGAAGGAGGGCCAGCACATGTGCCCGGACTGCGGCAAGGGATTCAACCATGTGAGCAACATGAAGCTCCACTACAAGGTGGTGCATCAGAAAGTGAAGGActtctgctgccgcttctgccCCAAGCGGTTCGCCAAAAAGCAGTATCTGCGCCACCATGAGTACATACACACGGGCGAGAAGCCATACGAGTGCAAGGTGTGCGGCAAACATTTCCGCCAGGAGCAGGTGCTCAAAACCCACATGAAGGTCCACGACAAGCCGCCGAGGCCCCCAAGCAAGCCCAAGGAGCCGGTGGCACCCAAGGCGGAAACGGTCAAGCGACAGCAGCCAAAGAACTTTGAGCAGTACCAGGATCCCGCTGCGGAGCGGgctgccgccaccgccgaACTGTTGGCCTACCAGCTGGAGGAGAACGAGGCCAAGCGGAAGGCGGAGGTGGAACTGCGGAAGATCCAGGAGGCGGCATTCGAGCAGTTGAACAAGCTGCAGAAGCAAACGAACACCTACGATGGCTTCTATGCCCAAAAGGCCGAGGCGGAGGGCACCACCGTCGATGCATTCAAATTGGATCATGTCTGA
Protein Sequence: MNEGSQYSIHTVCRTCLSTLHDTMAYDLFLIPGLAKKLCVCTSLSVEQQDGFPKNLCFNCYAKLNELHDFQKLCVDSVQKFQDLVSSNAFTCQTNFDVLDPSAAVADLPPDDEDHVNFDPLLNSKIEIIENEEDVFKMLEDVEKEVEEVEKDELGSAEESNDSSVESGNDNDQDEDFQLNSSDDDVPLAQRARRGNRRGPKAKASKRPVKEDSDEFSSFSDDSDSDGEKGGREKPKRKRIPAAERHLHRLIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCKVESCRKGFTTANGLRVHVEHAHTESSEMHPCTYEGCNKSFARPVLLNFHMKRVHKVDTPQRDFPCTECDKVFRCPTALKKHMYKHTGEELPFACEICGKRFPINSVLRDHLLRHAGIKNHVCPYCGVGKTTRQEWNKHILTHTKEKKYECRQCEHTSHNKQALANHVKVVHEKRKDFACQYCGKTFGKSHACKIHERSHTGEKCCECKICGKVFLFEKGLTKHLKTHEKSDLPRNQTTVNPLLAEVAAASSSSTIAKPSPHLRGRVERVDIAQLAGTVVNPIPSVNLPSWSPQVNFTKKEGQHMCPDCGKGFNHVSNMKLHYKVVHQKVKDFCCRFCPKRFAKKQYLRHHEYIHTGEKPYECKVCGKHFRQEQVLKTHMKVHDKPPRPPSKPKEPVAPKAETVKRQQPKNFEQYQDPAAERAAATAELLAYQLEENEAKRKAEVELRKIQEAAFEQLNKLQKQTNTYDGFYAQKAEAEGTTVDAFKLDHV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00487459;
90% Identity: iTF_00603534;
80% Identity: -