Basic Information

Insect: Drosophila affinis
Gene Symbol: topi
Assembly: GCA_037356375.1
Location: JAZHFB010000003.1:42967608-42970280[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 11 0.61 51 4.9 2.5 1 21 139 158 139 159 0.92

2 11 3.5e-05 0.0029 18.3 0.6 2 23 238 259 238 259 0.97

3 11 0.00095 0.079 13.8 0.1 2 23 286 307 285 307 0.97

4 11 0.092 7.6 7.5 0.0 2 23 374 395 373 395 0.90

5 11 0.00072 0.06 14.1 0.4 1 21 442 462 442 466 0.90

6 11 0.11 8.9 7.3 0.1 2 23 481 503 480 503 0.88

7 11 9.4e-07 7.8e-05 23.2 1.9 1 23 528 550 528 550 0.95

8 11 0.0021 0.18 12.7 1.0 1 23 556 581 556 581 0.94

9 11 0.46 38 5.3 1.7 1 23 587 609 587 609 0.88

10 11 3.9e-08 3.3e-06 27.6 0.4 1 23 615 637 615 637 0.99

11 11 0.0018 0.15 12.9 2.0 1 23 643 666 643 666 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	11	0.61	51	4.9	2.5	1	21	139	158	139	159	0.92
2	11	3.5e-05	0.0029	18.3	0.6	2	23	238	259	238	259	0.97
3	11	0.00095	0.079	13.8	0.1	2	23	286	307	285	307	0.97
4	11	0.092	7.6	7.5	0.0	2	23	374	395	373	395	0.90
5	11	0.00072	0.06	14.1	0.4	1	21	442	462	442	466	0.90
6	11	0.11	8.9	7.3	0.1	2	23	481	503	480	503	0.88
7	11	9.4e-07	7.8e-05	23.2	1.9	1	23	528	550	528	550	0.95
8	11	0.0021	0.18	12.7	1.0	1	23	556	581	556	581	0.94
9	11	0.46	38	5.3	1.7	1	23	587	609	587	609	0.88
10	11	3.9e-08	3.3e-06	27.6	0.4	1	23	615	637	615	637	0.99
11	11	0.0018	0.15	12.9	2.0	1	23	643	666	643	666	0.96

Sequence Information

Coding Sequence: ATGGATGACGAGAATTTCATGAGCATTGAGCTCGACGATGTGGTGCCCGTTGAGTACACGCTGGCAGAGATCGAGTTTGGCGACGAGTCCCAGTTGAATTTCACCCAACTGCCGGATGCCACAGTGGTTGCCACCAGCGAGGAGCAGAGCCAAGAGCAACTGGTCCAGTTCTTTGCCAGCGCCCCGCCACCCATCATGCAGATGTCCACCGAGGTGGTGCTCCAGCGCACTCTGGAGCACCCGGCGCTGAAGCAGATACTGCAGGAGGCCGACGGCCAGCCGGACTTTGATCCGGCAGCAGAGCAAATGAAAATACGCGAGTTCTTGGCTGGCGTCACCAACAGCAAGATGACCACAGAGGAGTCGGTCTTCCAAGCACAACGCATGAGCACGGCCTCGAATGGGTCCCGCATCTACAAGTGCCGTCACTGCGGCGGTAAGTTCGACGCTGTGTACTTCTCCAGTCACATCTGTTCGTGCGAAGATCCAAAGCCCGTCTACGATGGGCTGGGACATCAGGATAAGCCACGACCTCTGAAGATGTCGACGGAAGCGGGAACGGTGTCGTCGCCACGCTACGTTCGTGGCAGCGAGCGTGTCATCATGGAAAACCAAGTGCGCCTGCGCCGCTACATGAAGGACGAACTGAAGTACGACGTCACCACGGGCGTGGACAGCTCACTGCCCAGGAAGTCGGGCAAGCAGCCCAACGAGTGCAGCATCTGCGAGCGACAGTTCGTGCATGCCTCCGGCCTGGTGCGCCACATGGAGAAGCATGCCTTGAACCTGATCGCTCCAGCGGCCAATGCGCTCTCGAACCCGGCTCCACCTGCCTCCGGCCTGGCTGTGATGATAAAGTGCAACGTCTGTGGCCGCCTCTTCTACGACAGCAAGCTGGCCATGGACCACATCCGTGTCCACTATCCCGAACAGCCGAAGTTGGGCGAACCCCTGACGGGCGAGAACGAAGCCGAAAAGAAGGATTTCAGCAAGAAGATGAAGAAGGGGGACTGGCTCTTCTCGCATGTGCAGTCAAAGAAACGGAGCGGCGATCAGAAGCAGGAGAAGCGACCGTTGGAGGCCGGACTATTCAGCACACTGATCCTGGGCAGCGTGCTGCAGTGCGAGTTCTGCGAGTACGTGTTTGCGGACATTGAGAAGCTGCTCATCCACTCGGCCGCCCACGTGGTGGAGAGGCGCTTCGAGTGCACCGCCTGCAGTATAACGATGAACACGGCCAAGGAGGCCAGTGTCCACTTCCAGACGGAGTGCATCTTCATGCGCGAGGAACTCAAGCAGCTGGACGTCTCGCTGTTTCGGTACTTTGTGTGCAATGTGTGCGAGCAGAAGTTCTCCACCGCAGACCTGCTGCTGGAGCACCGGTACATCTACTACCACTACTTTCCACGCCTCACCGCCGAGGGCGGGCGCCTGCAGCTGCCCTGCGAGTACTGCGATGCCAACTTCTCGCACGCCCTCGCGGTGGAGGCGCACAGCCAGGAGAAGCACATGAACAGGAAGAGGCGCGAGAAGGAGACGCGCCCCAACGGGCCCAGCTACGGCAACGGACGCCTCCGCCAGTACCTGTGCGACGTCTGCGGCAAGTCGTACACCCAGTCCAGCCACCTGTGGCAGCACTTGCGCTTCCACCAGGGAGTCAAGCCCTTTGCCTGCCAGGAGGCCAACTGCGATAGGAAGTTCACCATCCGTCCGGACCTCAACGATCACATCCGCAAGTGCCACACTGGAGAGCGACCGTACCATTGCCTGGTGTGTGGCAAGCGCTTCCTCACCGGCTCCGTCTTCTATCAGCACCGTCTAATACATCGCGGGGAGCGGCGATACGAGTGTGAGGAGTGCGGCAAGCGGTTCTACCGAGCCGATGCCCTGAAGAACCACCAGAGGATCCACACTGGCGAGAAGCCATACAGCTGCCTCTTCTGCACCAAGACATTCCGGCAGCGCGGAGACCGAGACAAGCATATACGTGCACGACACTCCCATTTGGACGCCAACTCGCGTCTTATGATGCAGATGCAGAAGTTCCAGCTGGAGTCGGCGCAAGCGGCAAAGGCCAGAATCCGGCAGGAGCAAAAGGGCGACGGCCACAGCTACTCGACGGAAACATCAGGATCTCATGTCGGTCCTGAGGAAGATGGTCAGAATAACTCCGTTTCGGAAGAACAAGACGGAATGTATGGCGAGCCAATGAATGGATTCACCCTAAACCAATTTGAGATTCAGCAGTATGTGGAGGAGTCCGAGCCCACACCCATGAACGAAGGCGACGATGAAGAACTAATTGTGTACGAAAACCCTGAACCGATGGAGACAACGTCTTATGaaccaaagccagagccgCAGCAAACAACACGGGAGATTCCAGTGAAACCCGAAAGATCAAAGCGTAAGATTGTGGTGGTTAAGAATAATCCATCTCTGCCGCTTTATCCAAATTCGTACATGTAA
Protein Sequence: MDDENFMSIELDDVVPVEYTLAEIEFGDESQLNFTQLPDATVVATSEEQSQEQLVQFFASAPPPIMQMSTEVVLQRTLEHPALKQILQEADGQPDFDPAAEQMKIREFLAGVTNSKMTTEESVFQAQRMSTASNGSRIYKCRHCGGKFDAVYFSSHICSCEDPKPVYDGLGHQDKPRPLKMSTEAGTVSSPRYVRGSERVIMENQVRLRRYMKDELKYDVTTGVDSSLPRKSGKQPNECSICERQFVHASGLVRHMEKHALNLIAPAANALSNPAPPASGLAVMIKCNVCGRLFYDSKLAMDHIRVHYPEQPKLGEPLTGENEAEKKDFSKKMKKGDWLFSHVQSKKRSGDQKQEKRPLEAGLFSTLILGSVLQCEFCEYVFADIEKLLIHSAAHVVERRFECTACSITMNTAKEASVHFQTECIFMREELKQLDVSLFRYFVCNVCEQKFSTADLLLEHRYIYYHYFPRLTAEGGRLQLPCEYCDANFSHALAVEAHSQEKHMNRKRREKETRPNGPSYGNGRLRQYLCDVCGKSYTQSSHLWQHLRFHQGVKPFACQEANCDRKFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQKFQLESAQAAKARIRQEQKGDGHSYSTETSGSHVGPEEDGQNNSVSEEQDGMYGEPMNGFTLNQFEIQQYVEESEPTPMNEGDDEELIVYENPEPMETTSYEPKPEPQQTTREIPVKPERSKRKIVVVKNNPSLPLYPNSYM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00484659;
90% Identity: iTF_00481021; iTF_00473977;
80% Identity: -