Daff009133.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila affinis
Gene Symbol
ewg
Assembly
GCA_037356375.1
Location
CM074802.1:9970892-9975420[+]

Transcription Factor Domain

TF Family
Nrf1
Domain
Nrf1_DNA-bind domain
PFAM
PF10491
TF Group
Basic Domians group
Description
In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3.1e-108 3.5e-104 347.4 0.0 1 212 47 257 47 258 0.98
2 2 0.084 9.4e+02 -0.4 3.9 86 117 375 406 336 422 0.66

Sequence Information

Coding Sequence
ATGCTCGACGAGGACATCCAGAGCCTgggcagcgacgacgacgaggaggatcAGTTCAGCAGCGATGGGAGCCTGTACGACGCGGAGCTCGGCTCGATACCCGTCAACGATGACGTGGCCCATCAGCTGGCCGCCGCCGGACCAGTcggggtggcggcggcagcggccatCGCCAGCTCAAAGAAGCGCAAGCGGCCGCACTGCTTCGAGACAAACCCGTCAGTGCGCAAGCGGCAGCAGAACCGGCTGCTGCGCAAGCTGCGTGGCATCATCTACGAGTTCACGGGTCGCGTCGGCAAGCAggcggtggtgctggtggcaACGCCAGGCAAGCCCAACACCAGCTACAAGGTGTTCGGCGCCAAGCCGCTGGAGGACGTGCTCCGCAACCTGAAAAACATCGTCATGGACGAGCTGGACAATGCCCTGGCGCAACaggcgccgccgccgccccagGACGACCCGTCGCTGTTCGAGCTGCCCGGCCTAGTGATCGACGGGATACCAACGCCCGTCGAGAAGATGACCCAGGCCCAGTTGCGGGCCTTCATTCCACTGATGCTCAAGTACTCGACGGGACGGGGCAAACCCGGCTGGGGACGGGAGTCGACGCGGCCACCCTGGTGGCCCAAAGAGCTGCCGTGGGCCAATGTGCGGATGGACGCCCGCTCCGAGGACGACAAGCAGaagATCAGCTGGACGCATGCGCTACGCAAGATCGTGATCAACTGCTACAAATATCATGGGCGGGAGGACCTGCTGCCGACCTTTGCCGACGACGATGACAAGGTGAACGCTTTGATCTCGCAATCGggcgacgaggacgaggacatgGAGCTATCCAGCACGCCCACCATCCACACAGTGACAACAATGACGCCACCGTCAGGGAACAGCAATcagccgcagcaggtCAATGTGGTAAAGATCAACAGCGCCGGCACGGTGATCACCACCCACACAGCGCAGACCAACTCCCCGGCCCCGACGATCATCCAGAGCACCAACAACCAGCACGTGACCACCACGGCCACCTTGCCGGCCTCCACCAAGATCGAGATATGCCAGGCGCCGGCCCAAcaacaccaccagcagcagcaacagcagcaccagcaacaacagcaacagcagcagcaacaacatcatcaacagcaacagcagcagcaccaccagcagcagcagcaacaacagcaccaccagcaacaCCACCTCCCCGCCGGCAGCACCGTTCACATTCAGCCAATCAGCGGCGGCCAGCCGCAGACCATACAGCTGACGACCGCCAGTGGGACGACCACGGCCACCGCTGTTCCAACGACGGCCGCCGCCGTAAGTGCCGCCGCCCAGGCAGCGGCCGCAGCCCAGAACTCGGCCGCCCAGACCGTCACTGCCCAGCAGATAGCGAATGCCCAAGTTTGCATCGAGCCCATAACGCTGAGCGACGTTGATTACACCACGCAGACTGTTCTCTCGCAGAACGCTGATGGCACGGTGTCCCTCATCCAGGTGGATCCCAACAATCCCATTATCACGCTGTCGGATGGCACAACCGCCCAGGTTCAGGGCGTGGCAACGCTGCATCAGGGAGAGGGTGGAGCCACCATCCAGACCGTACAAAGTCTCACCGATGTCAACGGGCATGAGAACATGACCGTGGATCTGACCGAGACGCAAGATGGCCAAATCTATATCACCACCGAGGATGGGCAAGGCTATCCCGTCTCCGTGAGCAATGTGATCTCGGTGCCCGTCTCCATGTACCAGTCGGTGATGGCCAAtatgcagcagctgcagacgAACAGCGACGGCACCGTGTGCCTGGCCCCCATGCAGGTAGATACCAGTGCCACGCGCACCTCCAGCTCGGCCTCAGGGTCTCAGCCGCCGGCCAGCCAACAATCCCTGCAGTGCTACTCGCTGATCAGCGCCGGCCATGCCGTTCTGGGCAGAcgcggtggcagtggcgcgACCCTGGGGCACCACCAGTCGCTTACGTTGGCAGCTCCGGGGGCTCGCTACTATCTGGCGGCAGCGCCGGCGGCCACCGCAACCATTAATCACAGTAGCAGTAGCAATCATAGTAGCAGTAGTACGGGCTTTAATATCCACCAGAACCATAACCACCATctccacaacaacaacaacaacaatagtacccttgccaacaacaacaacaacagcagcagcagcatcaataACATTAGCATTAAGAGGGGGTCCCTCCCAATTCTGCTGGCAACTCCCAATCCCACTGCCCTTGCAACCACGACAAGCACCACCACGACGGCAGCTACCACAACACGCTCCACGCGACGTGTGGCGGCGACCACCAAGGCGGGAACCTTGGCACAAAAGCGTCGCAAGCCCGGGAGGAGCAGCCGCAAGGCACCCACAAAGGCGGCTGGCGAGACGTCCGCCTCCAGCGGATCCCCTGTGGGCATAGGCTCCTCcgcggcagcaacagctgccgCCATACGTTGCGTGGACAGTGCCAGTCTGACGAacatgcagctgcagctgccagcCAAGACTATTAAGTTGGAGAATTTTGAGTAG
Protein Sequence
MLDEDIQSLGSDDDEEDQFSSDGSLYDAELGSIPVNDDVAHQLAAAGPVGVAAAAAIASSKKRKRPHCFETNPSVRKRQQNRLLRKLRGIIYEFTGRVGKQAVVLVATPGKPNTSYKVFGAKPLEDVLRNLKNIVMDELDNALAQQAPPPPQDDPSLFELPGLVIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGRESTRPPWWPKELPWANVRMDARSEDDKQKISWTHALRKIVINCYKYHGREDLLPTFADDDDKVNALISQSGDEDEDMELSSTPTIHTVTTMTPPSGNSNQPQQVNVVKINSAGTVITTHTAQTNSPAPTIIQSTNNQHVTTTATLPASTKIEICQAPAQQHHQQQQQQHQQQQQQQQQQHHQQQQQQHHQQQQQQQHHQQHHLPAGSTVHIQPISGGQPQTIQLTTASGTTTATAVPTTAAAVSAAAQAAAAAQNSAAQTVTAQQIANAQVCIEPITLSDVDYTTQTVLSQNADGTVSLIQVDPNNPIITLSDGTTAQVQGVATLHQGEGGATIQTVQSLTDVNGHENMTVDLTETQDGQIYITTEDGQGYPVSVSNVISVPVSMYQSVMANMQQLQTNSDGTVCLAPMQVDTSATRTSSSASGSQPPASQQSLQCYSLISAGHAVLGRRGGSGATLGHHQSLTLAAPGARYYLAAAPAATATINHSSSSNHSSSSTGFNIHQNHNHHLHNNNNNNSTLANNNNNSSSSINNISIKRGSLPILLATPNPTALATTTSTTTTAATTTRSTRRVAATTKAGTLAQKRRKPGRSSRKAPTKAAGETSASSGSPVGIGSSAAATAAAIRCVDSASLTNMQLQLPAKTIKLENFE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00563636;
90% Identity
iTF_00603090;
80% Identity
-