Basic Information

Insect: Drosophila acutilabella
Gene Symbol: topi
Assembly: GCA_035046005.1
Location: JAWNOK010000061.1:155819-158393[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 4.8e-06 0.00037 21.0 0.8 2 23 238 259 238 259 0.97

2 9 0.0079 0.62 10.9 0.1 2 23 285 306 284 306 0.95

3 9 0.006 0.47 11.2 0.1 2 23 342 363 341 363 0.96

4 9 0.0078 0.6 10.9 0.4 1 21 410 430 410 434 0.90

5 9 4.8e-07 3.8e-05 24.1 1.9 1 23 496 518 496 518 0.95

6 9 0.00049 0.038 14.7 1.1 1 23 524 549 524 549 0.96

7 9 0.42 33 5.4 1.7 1 23 555 577 555 577 0.88

8 9 3.7e-08 2.8e-06 27.7 0.4 1 23 583 605 583 605 0.99

9 9 0.00068 0.053 14.2 1.2 1 23 611 634 611 634 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	4.8e-06	0.00037	21.0	0.8	2	23	238	259	238	259	0.97
2	9	0.0079	0.62	10.9	0.1	2	23	285	306	284	306	0.95
3	9	0.006	0.47	11.2	0.1	2	23	342	363	341	363	0.96
4	9	0.0078	0.6	10.9	0.4	1	21	410	430	410	434	0.90
5	9	4.8e-07	3.8e-05	24.1	1.9	1	23	496	518	496	518	0.95
6	9	0.00049	0.038	14.7	1.1	1	23	524	549	524	549	0.96
7	9	0.42	33	5.4	1.7	1	23	555	577	555	577	0.88
8	9	3.7e-08	2.8e-06	27.7	0.4	1	23	583	605	583	605	0.99
9	9	0.00068	0.053	14.2	1.2	1	23	611	634	611	634	0.95

Sequence Information

Coding Sequence: ATGGAtgaaaatgtggaaatgtTTGTGGATGGTGAGTTTGTCATGGCGGAGTTTGAATGCGAAGCCGAAATGGTGGATCGCAGTGGAGAATTGCAAGAGGGTGCCACTGTACTGGTGGCCAATGAGTCCGATGGCATTGTGAATTATGAAGATTTGAGCAAGCTCTTTGATCTATCGAGTGTCATAGAAATTGAAGCTGGCGACGATACCGTTGAACGAACATTAGCCGATCCGGTTTTGAAGGAAATACTTCAGAAAACCGATGATAAGATTGACTTTGATCCGAAGGCAGAGCAGGAGAAATTGCGTGAATTTCTTGCAGTTgctaacaataacaataaaattgccAGCAAGAAAAGTGTGCCAGCTCTAGGGGGCGCTCCGAATTCACAGCCTGTTATTGCGCCATCAACATCAAATTCCTTTCGTATTATCAAATGTTCCAATTGCAGTGGTCTCTTTGATACGCCCTCTTTCCAGACCCACAACTGTGACTACGATGCCAATCAGAAACCACTTGCAGTTCCTCCAAAGATGCCACCACCTCCGGACAAAGTGGTGGCTTTGCCAGCCATGAAACCGCCCAGCGAACGTATCATTGTTGAGAATCAGGTGCGCATACGTCGCTATATGAAGGAAGAGCTCAAGTATGATCTGGAAACAGGTGTGGACAGTTCCAAGGTCAAGAAGTCCTTGACTAAGGGCCCCAATGAGTGCAGCATTTGTGATCGCAAGTTTGTCCATGCCTCGGGGTTAGTGCGTCACATGGAGAAGCATGCCCTGGACTTGATTCCCACGCAGACCAATGTGCAGAATACAGCAATGGCTGCACTGGGTCTGCTTGTTGTGCTCAAATGCGACATCTGTGGTCGCATCTTCTATGATGTGAAGCTAGCACTGAAGCACGTCTCTGTGCATTTTCAACCAGCGACTGCATCCAAAAAGTCGCagattttaaatgaaaGATGTCACTGCACTGCGGATAACGAACACTTTTCCACGCTTATACTGAGCAACGTGCTCCAGTGCGAGTTTTGTGACTACATCTTTGCCGATGTGTCTTTCCTGTTGAATCATTCAGCTACTCATGTGCCGGAGCGACGGTTTGAGTGTACCGCTTGTGATCTGCGCATGACCACCGCCAAGGAGGCCAGCGTACACTATCAGACCGATTGTGTGTACATGCGGGAGGGATTAAAGCAGTTGCAAACGTCTCCCAATCGCTATTTTGTGTGCAACGTCTGTGAACTGAAGTTTGCCAATGTAGAAACGCTCCAGGAGCATCGCTACAGCAGCTACCACTACTTTCCACGTCTAAGCGAAAGTGGCAAGCGTTTGCTCCTTCCCTGCGAGTTTTGTGCCATTAATTTTGAGTATGCCCATGAGATTCAACCGCACTACGAGGAGAAGCATCTGAATAAAAAGAAGCGTGAGAAGGAAATGCGTAGTAATGGTAATCCAACAACTGTGGGGCGTTTGCGACAATATCTATGCGACATTTGTGGCAAGTCCTATACCCAATCAAGCCACTTGTGGCAGCACTTGCGTTTCCATCAGGGTGTGAAGCCCTTCGTTTGCCAGGAGGAAAACTGTGGACGCAAGTTCACAATACGTCCGGATCTCAATGATCATATTCGCAAGTGTCATACGGGAGAGCGACCGTATCATTGTCTGGTATGTGGTAAACGCTTTCTGACTGGCTCTGTTTTTTATCAGCATCGTCTAATTCATCGCGGCGAGCGGCGTTACGAGTGCGATGAGTGTGGCAAGCGATTCTACCGAGCGGATGCTCTGAAAAACCATCAACGTATTCACACGGGCGAGAAACCATATGATTGTCCGTTCTGCACAAAGACATTTCGTCAGCGTGGCGATCGTGATAAACATGTTCGTGCACGTCACTCTCACTTGGATGCGAATGCACGTTTAATGATGCAGATGCAGAAGTTTGAACTGGAAACAGCAGCTGCATTGAAGGCCAAGCAAATGCAAGAGACAAATgataatgattttatttcggATCCGTCCTCTGTTTCATTGGCCCATTTGGCACCTTCCTCTATTATGTCAGATCAGCAGTATGAGATGGTTGAAATTGATCCCAATGATTTTTGCGAAGCTCCCGATTTTGTACAAATGCCAATGCCGATGGATAATACAGATTATGAGGTTATTAACTATGGAGGTATTGAGGGAATGGACCCCATTGAGGCGCCACAGTTTCCAATGGACAGCGCTaaagttgtagttgtagaAAATAACTCGTCGCAGCCATTTTATTTCTAA
Protein Sequence: MDENVEMFVDGEFVMAEFECEAEMVDRSGELQEGATVLVANESDGIVNYEDLSKLFDLSSVIEIEAGDDTVERTLADPVLKEILQKTDDKIDFDPKAEQEKLREFLAVANNNNKIASKKSVPALGGAPNSQPVIAPSTSNSFRIIKCSNCSGLFDTPSFQTHNCDYDANQKPLAVPPKMPPPPDKVVALPAMKPPSERIIVENQVRIRRYMKEELKYDLETGVDSSKVKKSLTKGPNECSICDRKFVHASGLVRHMEKHALDLIPTQTNVQNTAMAALGLLVVLKCDICGRIFYDVKLALKHVSVHFQPATASKKSQILNERCHCTADNEHFSTLILSNVLQCEFCDYIFADVSFLLNHSATHVPERRFECTACDLRMTTAKEASVHYQTDCVYMREGLKQLQTSPNRYFVCNVCELKFANVETLQEHRYSSYHYFPRLSESGKRLLLPCEFCAINFEYAHEIQPHYEEKHLNKKKREKEMRSNGNPTTVGRLRQYLCDICGKSYTQSSHLWQHLRFHQGVKPFVCQEENCGRKFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECDECGKRFYRADALKNHQRIHTGEKPYDCPFCTKTFRQRGDRDKHVRARHSHLDANARLMMQMQKFELETAAALKAKQMQETNDNDFISDPSSVSLAHLAPSSIMSDQQYEMVEIDPNDFCEAPDFVQMPMPMDNTDYEVINYGGIEGMDPIEAPQFPMDSAKVVVVENNSSQPFYF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00534049;
90% Identity: iTF_00569171; iTF_00478921;
80% Identity: -