Basic Information

Insect: Drosophila acutilabella
Gene Symbol: zfh1
Assembly: GCA_035046005.1
Location: JAWNOK010000003.1:6146699-6151021[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 2.9e-05 0.0023 18.5 1.0 1 23 149 171 149 171 0.97

2 15 0.0009 0.07 13.8 1.2 3 23 179 199 177 199 0.94

3 15 9.8e-05 0.0076 16.9 0.1 1 23 352 374 352 374 0.98

4 15 0.00091 0.071 13.8 2.2 1 23 380 402 380 402 0.98

5 15 3.4e-05 0.0026 18.3 3.2 1 23 433 456 433 456 0.96

6 15 0.00065 0.05 14.3 1.9 1 23 498 520 498 520 0.95

7 15 0.075 5.8 7.8 1.8 1 23 526 549 526 549 0.97

8 15 0.029 2.2 9.1 0.4 3 19 558 574 557 575 0.95

9 15 0.00017 0.013 16.1 5.6 1 23 584 606 584 606 0.97

10 15 0.044 3.4 8.5 1.2 2 23 612 633 611 633 0.96

11 15 9.9e-06 0.00077 20.0 1.0 1 23 642 664 642 664 0.98

12 15 0.0011 0.088 13.5 0.1 3 23 672 692 670 692 0.97

13 15 6e-05 0.0047 17.5 0.5 1 23 698 720 698 721 0.95

14 15 0.17 14 6.6 0.3 1 23 731 753 731 753 0.96

15 15 0.0043 0.33 11.7 0.2 1 23 1292 1314 1292 1314 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	2.9e-05	0.0023	18.5	1.0	1	23	149	171	149	171	0.97
2	15	0.0009	0.07	13.8	1.2	3	23	179	199	177	199	0.94
3	15	9.8e-05	0.0076	16.9	0.1	1	23	352	374	352	374	0.98
4	15	0.00091	0.071	13.8	2.2	1	23	380	402	380	402	0.98
5	15	3.4e-05	0.0026	18.3	3.2	1	23	433	456	433	456	0.96
6	15	0.00065	0.05	14.3	1.9	1	23	498	520	498	520	0.95
7	15	0.075	5.8	7.8	1.8	1	23	526	549	526	549	0.97
8	15	0.029	2.2	9.1	0.4	3	19	558	574	557	575	0.95
9	15	0.00017	0.013	16.1	5.6	1	23	584	606	584	606	0.97
10	15	0.044	3.4	8.5	1.2	2	23	612	633	611	633	0.96
11	15	9.9e-06	0.00077	20.0	1.0	1	23	642	664	642	664	0.98
12	15	0.0011	0.088	13.5	0.1	3	23	672	692	670	692	0.97
13	15	6e-05	0.0047	17.5	0.5	1	23	698	720	698	721	0.95
14	15	0.17	14	6.6	0.3	1	23	731	753	731	753	0.96
15	15	0.0043	0.33	11.7	0.2	1	23	1292	1314	1292	1314	0.97

Sequence Information

Coding Sequence: ATGAACAATCAGGATTATGGCGGCATCCAATGGATACAGCAGCACGCATCTGCAGTCGACTCCGAAACGGATATGCTGGAAAGCGGCGCAGGCGACAGCGAGGTGACTGCAGCTTATTTGGTGAACGGCAATGCCACCGACGAGGATCTTGATCATATGGCGGCCGAGAATCTAATATTCATGGCCCGAGATGGTCAGCTAAGCGAAATAATAGCTGCCAATGAATCGGGTGGTGGCACGGTGCTCATCACCGACGGGGGCGTCGCTTATGCTGAGTCATTCGACGATGACGCCCAAGTGGTCACCGAGGAGATCATCACTGATGATTGGGTGCAGCATCAAGGCGCAGAGCGTGTGGAAATCGCCGCTGAGCAAATTGCTGGCAATGCAAATGCGCTGGAGCTACTGGATATGGAGCAGGACGAGTATACGGCACTGCGTCCCTATCCGTGTGATTTTTGTAGCCGGCGTTTTCGCAAAAAGGCCAGTCTCAACAATCATATGCTGGCGCATCAGAACGATCGTCCTCATCTGTGTAAACTCTGTGGAGCACGTTTCTCCCGTCGTGCTGAGCTCATCAGTCACTTCAAGGCACATGCCGAGGCACAGGATGCAGCGGATGCGGAggctgcagcggcagcgtcGATTAAATTTGAACCACAACAGACACAGCGACAAGTGGACGATCATTTCTATGAACAGGAGTGGCCACTGTACCATGAGCAGGAGCAACTACAGGATCAAACCCAGCAAGTGGAACAGGAACAAATTACCGTGGCCAGTCAGGTAGTGCAAGAAGCCAGCTATGCGGCAGTAAGCAATGTGCCAGCACCAACTGCCGCCCGCGGTCGCATCAGTCGCCTCAAGCCCAAGGAGGAGAGTAGCCAGTACATAGTGATTGCGGAGAAACAGACGCCAGATGAGCTGGCCCAGTTTGTAGACTGCGAGGAGCCGCTAACGGTGACTGCCACATCCAGTGATGCCAACAATGCCAAGGACAATGGCCAGGTCATGGACTCCTCTCGTTTCCCAGTGCTAGACGACAGCAAACCCTTCGTGTGCCAGCAATGCGGCTTAGCATTTGCCCGCGAGAAGGCGCTGGTGTCACACATCAAGAATCATCGCGTGGACTCGCCGTTTGAGTGTAATCAGTGCCAGGAAATGTTCTGGGACAATCACAGTCTGCAGGAGCATCAGAAGACACATCAGTTCGAAGAGAGCAATTCAGAGTATGATCCCGCTTCAGCGGGTGAGGACAGCGCCAGTGAATCTGAGCCAGATCAGCTATATGGAGAATTTTACTGCAGCGAATGTGGCATATCATTTCACAGGCAGGACCTGCTCCGACGTCACACCAAGCAGCAGCATAAGCTGTCCATGGCCAGCACTATGGCCTCCAATCCTGATGCGGAGGGCAGTGTAGATGCCGATGttgatggcgatggcgatatGGACGTCGATGGGGATGGTGAGAATACCAAAGATGCGACACATTGTTGTCATACCTGTGGCAAGTCATTCCCCAGCGCCTTAGAGCTACTTGCTCATGCCGAGATTCATGCACGTTTCCCGCCCTTCAAATGTGTCCTGTGTGGCAGTAGCTTCTATGAGGAGCAGGCCATCAAGCGGCATCTGCACACACGACATCCCCACGAGCTGAAGCCTAACTCGTGTGTGCTCTGTGGCAAGGAGTGTCGGGATCGCAAGGCCTTGATTAAACACGCCTGGGATCACTCTCGCGAAAAGTGCCACTCGTGCTCCAAGTGCGGCAAGAATTTCCACAACAAGGCGCGTCTGAAGCGGCACATGGCCTCGCATCGGGACAAGTCGGTGGTGTGCGAGGTCTGCCACGAGGAGTTCCCCGACGGACGCACACTGTCCAATCATCGGCATTCGCATAGCACCACATCGCCGGGCAAACTGTTTCCCTGCCACGAGTGCGGAAAGACCTTTGGCTCACGCAGCTCTCAGCAGATTCATGTGCGCATACATACGGGTGAGCGGCCCTACGGTTGTCGCTACTGCTGGAAGGCCTTTGCCGATGGCGGCACACTGCGCAAGCATGAGAGAATTCACACTGGCGAGAAGCCCTATGCCTGCTCCGTGTGTCCACGTGCATTCAACCAACGTGTAGTTCTCAGGGAGCACATTCGATCCCATCACTCGGGATTGGATTCAGTGCGTGGCACATATCATTGCACCGTCTGTGCAGCCGATCTGACCACATCCAATGAGCTCATCCAGCATCTCATTCAACACAGCGACACGAACACAGCCAAACAACGACAGCCAATCACTGGTCCCCGCAAGTATAAGCGTCGCAGAAAACTGCAGCCACATGAGATTGCTCATCTACGGGCGGAGAACAAGGATGAAGAGGATTATGGCAGCGATATGGATCTCTGTGATCTGGATATGGAAAATGTCGATGATCTCTTCGAGGCGGCGGAACCAGTGCCAGCCAAAAAGGAGAAACGCAAACGAACGGCCGGGGCCAAAACGACGTCAGTGCCCACAAATGGCGTCTCCACATCCGCtctgaacaacaacagcaacaataacaacaacacaagtAAAGTAGCCAATGGAAATCAGGATCGCCTGTGGGAGGAGAAGTTCCTGCAGGCTAATGGCAGTGGCGGTGGCACTGTACCCGCCTCCAATCCCTTGTCGGAGGATACGTTTAAGAATTTCTTTCCGATTGATTCATTGGTAGTGGTTAATGATACCACGCTGCAGCCCGTAAGCTCCTCAAGCGCCGGTGCCACCGTTGTGTCCAAGACACGACGTAGTGCCAAACAGGCGACTGGAGCAGCAGCGGGAGCAGGAGCCGCAGAAGAGTGCAGCAAGAGCAGTGCCTCCGCATCCTCAGGTagtcgcagcagcagtcgccgGAAAACTGCCAAATCCAACAAGAACTCCAGCACAACGACAGCCACAGCGAGCAGTTCGCGTCCCCGCATGATCCATACGGAAAAGTCACGGGTTAGTGGCGAGAATTCATCGAAACGGGCTCGGGGCAGATCCTATGTGACCAGAACAAGCACCAGCGAGAGCAGCCAGCTGGGTCTGGTCAAGTCTAGTGGTGTTGCCAGTTCCCGCATTGTGGATGACTATGAGATTATATCACCTGCCACACAGCCACCAAATCAGATCAGCTCAAGTCCGCTGCACATCAAGCTGGAACAggagcagcatcatcatcatcatcagcagccaCATCGTGTACCCCTCATGTACGATGACACACATCTGTTGATAGAGAAGAACTACGAGAAGTTTAATCCCAGCATTGTCAATGATCTCGAGGAGATCTTACGTAGTCCACTCAAACATGATCGGAATGCTCGTCTGCGTTTCACCAGCGAATCCTCAACAACGCCCCAGTTTCTGCCGGAGGAGGAGCagaatttaatcaaaattgaGCCCACGTCACCGGATCTAAGGGAAATGGTTGAGAGTCAGCAGCGTGTAAGTGCCACTGGTCATACAACTACGCCCTCATCCTCCTCGTCGTCGGCACGAACCTCACGTCATCTGCGCCAGCTCACTGCCAATTCTGGTTCACGGACGGCGACCAAACGACACCATCagcaccacagcaacagcagcaccagtaGCACTACCAAGTCCATGTCCGCCTCCAGTTCTAAGAAATCCACATCATCTTCGTTGTCTGCCAGCAGTAAATCCAACTCTTATCTTGGTTACGGCGTCGTGGACTCGTACAATGTGGGAGTTGCTACCAATACCAGCTCCTCGGACGTGAGCTCAGGTTTCTTTTCCATCTCCGAGGTGGTGTCCGCTGCCGATGCCGCCGACGCAGCCGCCAAGGCAGCAGCGGCCAATAAACCGGAGCGTCGTGCACGCTGCTTTGAGTGTGAGATGTGCTCGGCCAATTTCCCGGATCGTGCTCAGCTGCTGGAGCATGTGCACATACACATTTGA
Protein Sequence: MNNQDYGGIQWIQQHASAVDSETDMLESGAGDSEVTAAYLVNGNATDEDLDHMAAENLIFMARDGQLSEIIAANESGGGTVLITDGGVAYAESFDDDAQVVTEEIITDDWVQHQGAERVEIAAEQIAGNANALELLDMEQDEYTALRPYPCDFCSRRFRKKASLNNHMLAHQNDRPHLCKLCGARFSRRAELISHFKAHAEAQDAADAEAAAAASIKFEPQQTQRQVDDHFYEQEWPLYHEQEQLQDQTQQVEQEQITVASQVVQEASYAAVSNVPAPTAARGRISRLKPKEESSQYIVIAEKQTPDELAQFVDCEEPLTVTATSSDANNAKDNGQVMDSSRFPVLDDSKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNHSLQEHQKTHQFEESNSEYDPASAGEDSASESEPDQLYGEFYCSECGISFHRQDLLRRHTKQQHKLSMASTMASNPDAEGSVDADVDGDGDMDVDGDGENTKDATHCCHTCGKSFPSALELLAHAEIHARFPPFKCVLCGSSFYEEQAIKRHLHTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCHEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDSVRGTYHCTVCAADLTTSNELIQHLIQHSDTNTAKQRQPITGPRKYKRRRKLQPHEIAHLRAENKDEEDYGSDMDLCDLDMENVDDLFEAAEPVPAKKEKRKRTAGAKTTSVPTNGVSTSALNNNSNNNNNTSKVANGNQDRLWEEKFLQANGSGGGTVPASNPLSEDTFKNFFPIDSLVVVNDTTLQPVSSSSAGATVVSKTRRSAKQATGAAAGAGAAEECSKSSASASSGSRSSSRRKTAKSNKNSSTTTATASSSRPRMIHTEKSRVSGENSSKRARGRSYVTRTSTSESSQLGLVKSSGVASSRIVDDYEIISPATQPPNQISSSPLHIKLEQEQHHHHHQQPHRVPLMYDDTHLLIEKNYEKFNPSIVNDLEEILRSPLKHDRNARLRFTSESSTTPQFLPEEEQNLIKIEPTSPDLREMVESQQRVSATGHTTTPSSSSSSARTSRHLRQLTANSGSRTATKRHHQHHSNSSTSSTTKSMSASSSKKSTSSSLSASSKSNSYLGYGVVDSYNVGVATNTSSSDVSSGFFSISEVVSAADAADAAAKAAAANKPERRARCFECEMCSANFPDRAQLLEHVHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00579414;
90% Identity: iTF_00569124;
80% Identity: -