Basic Information

Insect: Drepana falcataria
Gene Symbol: topi_2
Assembly: GCA_945859695.1
Location: CAMAOO010000044.1:3651432-3654514[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.0023 0.14 12.8 1.0 1 23 15 39 15 39 0.97

2 9 1.1e-05 0.00066 20.1 1.7 1 23 45 70 45 70 0.96

3 9 0.00014 0.0088 16.6 2.9 1 23 80 102 80 102 0.98

4 9 0.0049 0.3 11.7 1.4 1 23 108 130 108 130 0.95

5 9 0.0054 0.33 11.6 1.0 1 23 136 158 136 158 0.97

6 9 0.00027 0.017 15.7 1.8 1 23 161 184 161 184 0.97

7 9 2.3e-06 0.00014 22.2 2.9 1 23 191 213 191 213 0.98

8 9 7.6e-06 0.00047 20.6 0.9 1 23 222 247 222 247 0.95

9 9 0.023 1.4 9.6 1.6 1 23 252 274 252 274 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.0023	0.14	12.8	1.0	1	23	15	39	15	39	0.97
2	9	1.1e-05	0.00066	20.1	1.7	1	23	45	70	45	70	0.96
3	9	0.00014	0.0088	16.6	2.9	1	23	80	102	80	102	0.98
4	9	0.0049	0.3	11.7	1.4	1	23	108	130	108	130	0.95
5	9	0.0054	0.33	11.6	1.0	1	23	136	158	136	158	0.97
6	9	0.00027	0.017	15.7	1.8	1	23	161	184	161	184	0.97
7	9	2.3e-06	0.00014	22.2	2.9	1	23	191	213	191	213	0.98
8	9	7.6e-06	0.00047	20.6	0.9	1	23	222	247	222	247	0.95
9	9	0.023	1.4	9.6	1.6	1	23	252	274	252	274	0.96

Sequence Information

Coding Sequence: ATGGATGAGTGGATGCCAGTTCAAAAACCAGAAAAGAAGTTACACAAATGTCCGCACGAAGGTTGTGTAGCAACTTTCAACAGACCATATAGATTGGAACAGCACATTCTACTGCACTTTAATTTTAGGCCATATATATGCACACAAATTGATTGTAAGAAATCATATTCTAGTAAAAGCCACTTGGATCGCCATGTAAATAGTGTACACTTGGGCATGAAAAGAGAAATTGAAGCATACAGCTGTCCGTCATGCCTGAAACTGTATGCAAATCACCAGAACCTCAAAAGGCACATGAAGTCCCATATAAAGAGAATGTCATTCTCTTGTGATGTTTGCAATTTGGAATTTAAAAATGATAATCAGCTTAGCACACATAAGTATCAGCACACTGGTGTCAAACCATTTATATGTGACATGTGTTCTGAAGCATTCCTTACTCTGTATGAAAAGAAGAGACATATGAGGTACCATAAAATGTACAACTGCGAGGAATGTGGCATACAATTTAACCATTGGAACAAGTACAGAGAGCATAAAAAATCCGCTCATGATAAAAGGGATGGGGACTTTGTCTGTGATCAATGTGGGAAGTCATTCAAACAAAGATGTGAAATACTGAGACACATCAAAACCCATACAAGACCATACTTTAATAAAATATTTATGTGCCCACATGCAAATTGTGAAAGAGTATACACGACGAAAAGCAACTTAAAGCAACACATTGCAGTAAAACATATGCAAATATTTCACATATGTATGCTGTGCAATGCTCGCTTATCAACGAAGGCAAAATTAAATTATCATCTGAAACTGCATGAACGAAATGGTATGGTGATTCCAGAAGAGGCTCACAATAATACTGGTCCATTGATTCCCAAAAACGAGCCTGAAGAATTAGATGATGCTCAAGACAATCCATCTTTAGACCTAAATGAGCTACAAATACTGGAAATTAAGGTAGAACCCCAAGATATACTTGAACCTCCCAGTCCAGAATCTGAGAGTGACATGAAATCAGAAAATGATGAGGAAATGACATAA
Protein Sequence: MDEWMPVQKPEKKLHKCPHEGCVATFNRPYRLEQHILLHFNFRPYICTQIDCKKSYSSKSHLDRHVNSVHLGMKREIEAYSCPSCLKLYANHQNLKRHMKSHIKRMSFSCDVCNLEFKNDNQLSTHKYQHTGVKPFICDMCSEAFLTLYEKKRHMRYHKMYNCEECGIQFNHWNKYREHKKSAHDKRDGDFVCDQCGKSFKQRCEILRHIKTHTRPYFNKIFMCPHANCERVYTTKSNLKQHIAVKHMQIFHICMLCNARLSTKAKLNYHLKLHERNGMVIPEEAHNNTGPLIPKNEPEELDDAQDNPSLDLNELQILEIKVEPQDILEPPSPESESDMKSENDEEMT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00724204;
90% Identity: iTF_00724204;
80% Identity: -