Basic Information

Gene Symbol
-
Assembly
GCA_016069955.1
Location
JACCPG010004428.1:33728-48743[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.0012 0.1 13.5 1.0 3 23 295 316 294 316 0.97
2 13 0.74 63 4.7 0.1 2 19 354 371 353 374 0.86
3 13 0.052 4.5 8.3 1.8 3 23 380 401 379 401 0.93
4 13 8.8 7.5e+02 1.3 1.2 1 8 632 639 632 640 0.90
5 13 0.049 4.2 8.4 1.2 1 23 662 684 662 684 0.92
6 13 0.0017 0.15 13.0 0.5 2 23 690 711 689 711 0.97
7 13 0.83 71 4.6 0.6 5 23 804 822 802 822 0.92
8 13 0.0046 0.39 11.7 0.7 2 23 838 859 837 859 0.97
9 13 1.7e-07 1.4e-05 25.6 2.7 1 23 865 887 865 887 0.98
10 13 1.4e-06 0.00012 22.7 1.3 1 23 892 914 892 914 0.97
11 13 7.7e-05 0.0066 17.2 2.3 3 23 922 943 920 943 0.92
12 13 7.8 6.7e+02 1.5 0.4 1 19 950 968 950 969 0.83
13 13 1.1e-05 0.00093 19.9 1.0 3 23 982 1003 981 1003 0.96

Sequence Information

Coding Sequence
ATGGAGCTTGTGAACGTTAAACCAGAACCTTTAGCCGAAGAATCATTGATTTCTTCATCACTGTCTCACCTGCAGTTCTCTGTCAACATCAAAGTTGAAGAATACAATGAATGTGACATCAAGCAAGAGCCGTTGGACTCTAATGATGCAGAGGTTATAGAAGTACTTGATGATGACACGGATCATGTGGCTGTTAAACGTCACAAAACTAAAGATGCTTTGAAGCCTGCAGTTCCTGTGAAGCGTAGAACAGCTGTTAAGGCAAAGAGGTCTAAGGTTCAAAAAGCCAAACATGAAAATGACGAGAAATCATTCAAAGAATATGTATTAAGCACAGTAAAAATTGCCAGGGAGCTCAGGTACCTGCGCTCCCCATCCTTAGCAGACAAGCTGATGAGCATCGAAGTCCGGAACATGCTCGGTCACACATCAAGACAGTCGATATTAACAGACAAGTATGATAAAATGATAGAAGTTGCCTTTAGTAATTCAAAAGTTTGGTATTACATATCCAAACATGGCGAATATCCAATGTTCTACAAGTGCTACATATGCTATCAGGCTTGGTGGCACCTGTACGACTTCCGGCAACACGTAAAGAGGCACATGGAGCCCCATTTCAAAATACACTTCGAAGATGACTTCCAGTTGTTCAGTACAGGCTATAACATTATTGCATTCGAATATTCCGTACCAGAGGTTACGAATATACCCATAGACGGACTATGCTGGCAGTGTAACCTTGGTTTCGCACATCATATATTAAGGAATGGGTTGCCAGCGTCATGTGAGCAATGTAAGGAGAAGTTACAGTCATGTAGGATGCGACTTAGACACGTTAATACATGTCCAAAGACTGTGTTGGAGTTGAAGTTGTCCTTATGCTCCTTTTGCTTGATTACCTTCAAAACTAAAGACTCACTGAGTAATCATATGATAAGCTACCATTCTGTAAGATCTGACATAATATCTACGACGTATTGCAAAGTGTGTCTCATTTGCAAGGAGAAATATATACAGTACAATGTTCACCCTTGCCCCAAGAAGAAGGTGAAGGATGTTTGCATGTTCTGTCACAGACGGTTCGTTACATCCAACTTGGCAGAGGTCCACGGTCAGATATCCAACCCTGGGAACTGTCCCATATGCCAGGAGAAGTTCAAGAAATCCTGTATGATAACAAGTCACATAGCTCTAAAGCACAGTGCGAATTTTGTCATAGCCTACAAATGTTTGTTGTGCGCGAAGTTCTTGGTCTGTCTAAGCATTGACCATTTGAAGAGGCACATGAAAAAGAAGCATTATGTAAAATATGACAGGAGGAGGACTGGCGCTATCTCGGTAATACTGCCAAAGACATGCTTCGATCCAAATTTCAAGCCTGTCACAGACCAAAGAGTTGAGATCAATCATGTCTCCCTGGTTGGAAATACTGGTCATAAGGGCACCCAGCATCGGACTGAAGTTGGAACTCAAACCGCACAAGTTTCTGCTGTCACATCACCGGTACCTGAAACTTCTATGTTAGAAATGGCAATAAGTCATATCAAACAAACCGAACACCTTGACCGGGCACTTCCCGACCCTGAACCAGAACAGCCAGCTGTCACACAGATCAAAGACGAAGTACTTGGCACAGACGTCGTAGAAGTTAAAGAGGAGCCACTGGAGGACTCGGAGACTGAACAAAGCATCAGCAGAACAGAGTTTGAAAGCATCTTTGGTGTTTTAAGCGATGTGAAAGAGGAAGAACCCCTTGAGGGTATTGAAGTTATAGTGAAGCAGGAGGCCGCCGAGGACTCAGAATTACCAGAGGCTTTACACTTTGAAGATCTCGATGACCCGATAAGTCTCGACCAACCAGAGAATAGCAGCGGGAGGCTGCCCAAAATGTACACTTGCAACAAATGTGGCTACATTGACGTCCACAAACAATATAAATGGCACATAGACAACAACTGTCGGAGTTATAAGAATGACAAGTACGCTTGCTCGCTCTGTGGCAACAGTTTCAGAAATTTGGTGAAGTATTTGCAACATTTCTATCAGCATGGCATCCCCTGCCTGACCTGTCCCGAGTGCAGGCTTACCTTCAAGGAGATATCCAAGTTGACTTACCACGTGAACATGCACATTAAATACAACTTTATCAAGATTAATTTGCTGGATAAAGAGGAGTCGTCCAAGAAGTGTCACTGTAGGCAGTGTATGAGCTCTGTGGAGGTCAGTGAGTATTTTAAGCATTGGGAGAGTCATCTCGCAGCGCGTCTGGAGAGGAGGAGTACTGATGCCGTGGCTGTGGCTAGTGTTGATACAGTGTCGGCGCTGGAACCGGATGTTCTGAAAGCTTTGACAGGTCGTTTGCAGCTAACAGAGTCTGTAAAGCAGATGGCACTTAAGGGGTGCATTGTGTGTAAGAAACGGTTCGTGCGCCTCAACGACTCCAAGCGGCACATCATAGAACACCTGCTGACCGACGCGTACGCCAACAGGCCGGCGAACAAAATGCTCAAGTGCCAAATATGCGGGGACGGGTTCGACAAGCAGGAACGTTTCAAATACCACATGAGGATCCACGGGGCGCTCACCCTGTATAAGTGCGAACTCTGCGACAAGTCGTTCAGTGACTCGAGTAACTTCACCAAGCATAAGAAGATCCACGATATGAAGGTGTTTGTTTGCGACAAATGCTCAAAGAAGTTTGTCAACAAGAGCTCGCTGGAGAAACATATATTGAACCACAGACACTATACTCCAACCAACTGTCAAGAATGCAACAAAGTCTTTTGTTCCGCTTCTGCATACAGGAAACATATGACAGCCAGACACTCAAATGTCAGGAATAGATATAAATGTATTATTTGCAATGAGAAGTTTGATTCGCTAAAGAAAAAGTGGGACCATCTTTGGTTGGTACACAAGGAGAGGAAGAATGATGTTGACTGCAATCTATGTGACAAGTCTTTCCGCAGAAGATTGGACCTCAGGGCGCACTTAAGAAATGATCATCAGATATATATACGCAGAAGACAATATCATAAATCGCACATTATTGGCAGTTCATTAAAACAGGGAAAGACAGAGAAAAAATGTGGTGAGAAGAGAGAAGAAGTGCTTAATACTGTTACAGACACAGTGATTAAAAAAGAACAGTCCGACAGTGACACAGAAGTGGCTAGTAGTGCGATAAGTAGTGTAGAAGTGATCAGTAGTGAGATGAATAGTGAAGTGTTGAAGGGGAACATAATATTCAACGCGAATGGTGTGACTTACTCAGTGATGCCTTCCATCCAGCTGGAGGAGCTGCCGACGCAGGGGCTGGAAACTCTTGTCTTCTTTGAGTGA
Protein Sequence
MELVNVKPEPLAEESLISSSLSHLQFSVNIKVEEYNECDIKQEPLDSNDAEVIEVLDDDTDHVAVKRHKTKDALKPAVPVKRRTAVKAKRSKVQKAKHENDEKSFKEYVLSTVKIARELRYLRSPSLADKLMSIEVRNMLGHTSRQSILTDKYDKMIEVAFSNSKVWYYISKHGEYPMFYKCYICYQAWWHLYDFRQHVKRHMEPHFKIHFEDDFQLFSTGYNIIAFEYSVPEVTNIPIDGLCWQCNLGFAHHILRNGLPASCEQCKEKLQSCRMRLRHVNTCPKTVLELKLSLCSFCLITFKTKDSLSNHMISYHSVRSDIISTTYCKVCLICKEKYIQYNVHPCPKKKVKDVCMFCHRRFVTSNLAEVHGQISNPGNCPICQEKFKKSCMITSHIALKHSANFVIAYKCLLCAKFLVCLSIDHLKRHMKKKHYVKYDRRRTGAISVILPKTCFDPNFKPVTDQRVEINHVSLVGNTGHKGTQHRTEVGTQTAQVSAVTSPVPETSMLEMAISHIKQTEHLDRALPDPEPEQPAVTQIKDEVLGTDVVEVKEEPLEDSETEQSISRTEFESIFGVLSDVKEEEPLEGIEVIVKQEAAEDSELPEALHFEDLDDPISLDQPENSSGRLPKMYTCNKCGYIDVHKQYKWHIDNNCRSYKNDKYACSLCGNSFRNLVKYLQHFYQHGIPCLTCPECRLTFKEISKLTYHVNMHIKYNFIKINLLDKEESSKKCHCRQCMSSVEVSEYFKHWESHLAARLERRSTDAVAVASVDTVSALEPDVLKALTGRLQLTESVKQMALKGCIVCKKRFVRLNDSKRHIIEHLLTDAYANRPANKMLKCQICGDGFDKQERFKYHMRIHGALTLYKCELCDKSFSDSSNFTKHKKIHDMKVFVCDKCSKKFVNKSSLEKHILNHRHYTPTNCQECNKVFCSASAYRKHMTARHSNVRNRYKCIICNEKFDSLKKKWDHLWLVHKERKNDVDCNLCDKSFRRRLDLRAHLRNDHQIYIRRRQYHKSHIIGSSLKQGKTEKKCGEKREEVLNTVTDTVIKKEQSDSDTEVASSAISSVEVISSEMNSEVLKGNIIFNANGVTYSVMPSIQLEELPTQGLETLVFFE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00468497;
90% Identity
iTF_00468497;
80% Identity
-