Basic Information

Gene Symbol
-
Assembly
GCA_963691745.1
Location
OY829500.1:6399098-6407739[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.0031 0.19 12.9 5.9 1 21 805 825 805 826 0.93
2 13 0.00011 0.0069 17.5 0.5 1 23 848 870 848 870 0.99
3 13 0.00096 0.06 14.5 2.4 1 23 876 898 876 898 0.95
4 13 8.4e-05 0.0053 17.8 4.5 1 23 901 923 901 923 0.98
5 13 8e-05 0.0051 17.9 6.0 1 23 929 951 929 951 0.99
6 13 0.00012 0.0074 17.4 1.7 1 23 957 979 957 979 0.98
7 13 0.00015 0.0095 17.0 1.5 1 23 985 1007 985 1007 0.98
8 13 1e-05 0.00063 20.7 2.8 1 23 1013 1035 1013 1035 0.97
9 13 1.5e-05 0.00091 20.2 3.9 1 23 1041 1063 1041 1063 0.96
10 13 0.00086 0.054 14.6 0.4 1 19 1069 1087 1069 1089 0.96
11 13 0.011 0.69 11.2 8.9 1 23 1096 1118 1096 1118 0.97
12 13 2.4e-05 0.0015 19.5 0.9 1 23 1124 1146 1124 1146 0.98
13 13 0.0017 0.11 13.7 1.2 1 23 1152 1174 1152 1174 0.97

Sequence Information

Coding Sequence
ATGGAGGTGTCACTATCGACCGGTTCAAAATTCAACGGCGAAAATTGGCCGTTATGGAAGTTTGAAACGCAAGTATTATTAAAAGGTCGAGggttatttaatattgtttcgGGGaccaagaaaaaaattaaagatgccACTGAAAAAGAATGTGATGGAATGGATGCGCTCGACGCCAAGGCCCAAGAAATTATTGTCACGCGAATGCAGTACGGGCCGCTCGCGCACATTCAATCATGTGAGACGTCGGCGGAGATGTGGACTAAATTGAAGGCAGTGTACGAAAAAGAGTCTGTCGTGAGCGTTCACTTACTCCAACAGAAATTCTTTACCATTGATTTTAGTACGGATTCAGTCGCCACATTCATGTCCAAAATAGAAGACATCCGTGTTAGACTAAAACAAGCTGGTCACCCTGTTGATGATAAGATGGTCATAACTAAAATCCTAATGTCTTTGccagaaaaatataaacattttcgGTCAGCGTGGGAGTCTGCCCCGATTGAAAGACAAACACTCGAAGAGCTGGTGCCACGTTTGCTGCTGGAAGAAGAACGAGCTAATGCCGGAGACGATATGGCGGTCGCGCTCGTGGCACAGCGCAGAGGCAACGGGAGCAGAGCACTGACTGAGTGCGCCGTATGCGGCAAGTCTGGCCATTCCAAAAAGGATTGCTATAAAACCAAGACGTGCGGCTACTGTAAAAAGACGGGCCATCTGACTAAATTTTGCttcttcaaaaataataaattgaaaaagaagAGCAAAGATGACGAGCAAGCCCTAATAGCGTCTGATATGAATAGTTCGTGCGACATTTGGTATATGGATAGTGGTTGCACTCAACACATGTGCAGAAGTCGAGAGAACATGTCAGAATATAAAGATTTGGACTATGAACATTTTGTGCAGCTTGGCGATGGAACAACTATAAAAGCCCTCGGAGTGGGGAGCGTCCGTTTGCAGGCTTATAATGGCACAGATTGGCAGATCGTTAGATTAAAATCTGTTTTGTATGTTCCAGATCTGAACGCGAATCTTTTTTCTGCAACGAGTGCACTAGATAAAGGCTTACAGATGATATCTGACCAAACCATTTGCAAGTTCATGAAAAGCATTTTTGGCTCTGAGGTGTGGTCTCATATTCCCAAGGAACGGCGACGAAAACTAGACAGTAAGGGCAGAAAAGGAATTTTCGTTGGCTATGGCGAGACAACAAAAGGCTACAAGATATTTTATCCAGAGAGCAAAACTTTTTCTTTGGAGAGAGAAATAATAATATCGCCTCATCTTCAGCCACATGTCACTGATAAAGTTGTCGAACAAGTTGCCACGATAAATTTAGATGTAACTATACCACGTGCTACGTCGGTAAATTCATCAGAGGTAGAGACGGTCAACTTTGAACAAAATGTGACATTAAGTCCAGATACGTCCGTTTCATATACAGATGCCGAAGATGTGCCTGTTGACAGCTTCGAGAGTCCTGGAGGTCTCAGTACAGTTCCAATTGAGCAAGCGGATAACATGAATACAAGGATTTTGCGACCAAGAGCAAATTTAAGACCACCTGTTGCTTTACGAGATTATGATATGTCTTACTTTACATTTTTAGATTCTGAAGAGCCTACGTCACTAAAAGAGGCTAAATCTTCTCCATGTGCCTCAAAATGGGAAGAGGCCATGAAGATGGAAATGAAGGCCTTATCCGATAATCAGACTTGGACATTTATTGACAAGCCTGAGGACGGTGTGTTAACTGTAGACATAGTTCAGAACATCATGGACGAAATGTCTAAAGctttcaaaatgaaatatttgggATTGGAAGAACCGAAATGGGACGTTGAGAGCGAAGCGGCCGCGCCGGCAGCTTTAGGCAACGAAGAGCAGGGAAAACTTGAGTTCAATCCACACATAGTCAAACTTGAATCGGATACACAACACGAGAAAGTTGAGTTAAATAACCACCATTGCAAGCATGAATTCAATGCACAACACGAGAAAGTTGAGTTAAATAACCACCATTGCAAACATGAATTGAATGCACAACACGAGAAAGTTGAGTTAAATAACCACCATTGCAAACATGAATTGAATGCACAACACGAGAAAGTAGAGTTAAATGAACACCATTGCAAAAATGAATTGATTGCTCAAAACGAGGAAGTTAAATGGAATGTACATCATGAGGTCAAAATTGAGGTGGAAGTAGAGCCAGAACTGCTGCAACGGCAAGATGCAGGCTACTCCGTGCAAGTCCCGCTGAACAAAGAACGCCCAGGACATGTCAAGAAGGAATTGACGCAGGCCACTGCTGGAAGAGCACTTGATGTGCCCTCGAATCGTACAGAAAACCCTGAGAAGGGCCTGCGTTCCATGGACACCTCCCAACCGGTTGATAACTTGCACTTTTGCAAGATTTGCCATCGAGTGTTCACACATAAACCAAGTCTCAGGACTCATCTTTGCATAGAACCCCAGGAACTAACTGACATGGAGAAGAAAACGCTTCCCAGCGTAATGCATGAAAACATTTACTCATGTGATACTTGTAAGAAAGTGTTTTTGGACAAAAGCTTGTTGATAGATCACATACAAACGCACAACGTCGAGAGAACGTACACCTGTAGGGTGTGCAACAAGGTGTTCAATACTCCCAGCAGTCTGAGGTGTCATACTGACATCCACAGGGATTTTTCATGCGAGTATTGTGATAAAAAATTCCAATTCAAGTCTCATTTAGTTATGCACGAACGTACGCACACCGGAGAGAAACCATATACTTGCCAGATTTGTAATAAACAATTCACACACAAAGCACACATAGTCAGACACACGCGCACACACTCGGGAGACAGACCTCACACATGCCAAATCTGTAAAAGGAACTTTGCTGAAAAACCGACTTTAATGCGGCACATGCAAATTCACACAGGTGAGAAACTATATTCCTGCGAAATCTGTAATAAACAGTTCCGTAATAAAGCTTACATAGAAACGCACAAACGCCTCCATAAAGGTGAAAAACCGCATTCTTGTAAAGTATGCGAAAAGCAATTCACACAGTTGAGTTCCCTGAAGGACCACATGAAGATTCACACGGGCGAGCGGCCGCATTGTTGCGAAGTGTGCAAGAAACGGTTTGTGCAGAAAGCAAACCTGACTATACATATGCGAGGCCACACCGGCGAGAAACCTTATTCGTGTGACGTGTGTAAGAAACTGTTTGCGAGCTCCTCTGCTTTGAGAAAGCATGAGTACTGCCACCTGCAAAAGCCGCATTCATGTCACATTTGTAAGAAACAGTTTACAGAGGACTGTCATTTAATCAGCCATATGAGAATACATACTGGAGAAAAACCATTCACATGCCAAGTTTGTAACAAACAATTCTCATTGCAAGGCTATTTGGATAATCATATGCGAGTGCATACAGGTAAGAACCCGCACTCCTGCCACGTCTGTGACGAACAGTTTTTGAATAAAGCTGCTTTAGCCAGACACGTTCGGATTCACACATGA
Protein Sequence
MEVSLSTGSKFNGENWPLWKFETQVLLKGRGLFNIVSGTKKKIKDATEKECDGMDALDAKAQEIIVTRMQYGPLAHIQSCETSAEMWTKLKAVYEKESVVSVHLLQQKFFTIDFSTDSVATFMSKIEDIRVRLKQAGHPVDDKMVITKILMSLPEKYKHFRSAWESAPIERQTLEELVPRLLLEEERANAGDDMAVALVAQRRGNGSRALTECAVCGKSGHSKKDCYKTKTCGYCKKTGHLTKFCFFKNNKLKKKSKDDEQALIASDMNSSCDIWYMDSGCTQHMCRSRENMSEYKDLDYEHFVQLGDGTTIKALGVGSVRLQAYNGTDWQIVRLKSVLYVPDLNANLFSATSALDKGLQMISDQTICKFMKSIFGSEVWSHIPKERRRKLDSKGRKGIFVGYGETTKGYKIFYPESKTFSLEREIIISPHLQPHVTDKVVEQVATINLDVTIPRATSVNSSEVETVNFEQNVTLSPDTSVSYTDAEDVPVDSFESPGGLSTVPIEQADNMNTRILRPRANLRPPVALRDYDMSYFTFLDSEEPTSLKEAKSSPCASKWEEAMKMEMKALSDNQTWTFIDKPEDGVLTVDIVQNIMDEMSKAFKMKYLGLEEPKWDVESEAAAPAALGNEEQGKLEFNPHIVKLESDTQHEKVELNNHHCKHEFNAQHEKVELNNHHCKHELNAQHEKVELNNHHCKHELNAQHEKVELNEHHCKNELIAQNEEVKWNVHHEVKIEVEVEPELLQRQDAGYSVQVPLNKERPGHVKKELTQATAGRALDVPSNRTENPEKGLRSMDTSQPVDNLHFCKICHRVFTHKPSLRTHLCIEPQELTDMEKKTLPSVMHENIYSCDTCKKVFLDKSLLIDHIQTHNVERTYTCRVCNKVFNTPSSLRCHTDIHRDFSCEYCDKKFQFKSHLVMHERTHTGEKPYTCQICNKQFTHKAHIVRHTRTHSGDRPHTCQICKRNFAEKPTLMRHMQIHTGEKLYSCEICNKQFRNKAYIETHKRLHKGEKPHSCKVCEKQFTQLSSLKDHMKIHTGERPHCCEVCKKRFVQKANLTIHMRGHTGEKPYSCDVCKKLFASSSALRKHEYCHLQKPHSCHICKKQFTEDCHLISHMRIHTGEKPFTCQVCNKQFSLQGYLDNHMRVHTGKNPHSCHVCDEQFLNKAALARHVRIHT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-