Basic Information

Gene Symbol
Lman1
Assembly
GCA_029229535.1
Location
CM055259.1:32722794-32734675[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.0033 0.3 12.1 0.4 2 22 92 112 91 112 0.93
2 12 0.33 30 5.8 1.7 1 23 138 160 138 160 0.93
3 12 0.47 43 5.3 2.3 5 23 170 188 165 188 0.92
4 12 0.0002 0.018 15.9 1.6 2 23 196 217 195 217 0.98
5 12 0.13 12 7.1 3.2 1 21 225 245 225 246 0.95
6 12 2.1e-05 0.002 19.0 4.2 2 23 250 271 249 271 0.96
7 12 0.0011 0.1 13.6 1.9 1 19 277 295 277 299 0.91
8 12 7e-05 0.0064 17.4 0.9 1 21 305 325 305 328 0.90
9 12 6.7e-06 0.00061 20.6 3.2 2 23 351 372 350 372 0.96
10 12 4.8e-07 4.4e-05 24.2 1.1 1 23 378 400 378 400 0.99
11 12 6.3e-06 0.00057 20.7 0.9 1 23 406 428 406 428 0.98
12 12 5e-05 0.0045 17.8 0.4 1 23 434 456 434 456 0.98

Sequence Information

Coding Sequence
ATGAAACATGTAGTAacaataaaacaagaaataataacGGAAAATCTGTGTGATCATGTCAAATCAAACGAAgctttaaaaatagaaattaaggAAGAAATTAATGATGTAGATGATATATTTGAAGAAACTCCTGAAGTTAAGACtgaattttttgatgaaactgAAAGTACAGGGGAAGTTATCGAAgATGGCGAGTGTTCTGAAAATGTCTTAAAAATGGAGATTGGAGATGAAGGTCTCCAATATAAGTACGAAGAAAATATACCGATTCATTGTTCTGTTTGTAACAGATCTTTTGAAACTACCGGCGGGTTATTGAATCATTTGAAACGAAGGTTGAGGTGCAGATATCAAACGAAATTTGTTGCCCaattttggaaatgttttttaaaaaaagtcgCCAAGCCTTTTAAATGCCAAGTGTGCCTTAAATatttttcttcgatatatcAAAAAGACAAACACACCGAAGCTCATTTTGGTAAAGCTTGCGTAGCGTGTATTTTCTGCGGTGAATATTTCATCAAACAAAAAGAGTATTTACAACATTACAGACACCATTCGACCAAACAATTCCCTATAAAATGTAAAACTTGCCCTAGAAGGTTTCCCACCAAAACCGTCTACATCAAACATTTAAAAACCCACAAAGACATTTCGAAAAATCGATACAGATGCAAAAAATGCGGCTCGACGCATTCCAAAAAATCGCTATTGCTAAAACATAcgcaaaaagaaaaattaaattgtgcCTATTGTACGAAAACGTTTTGTAAAAAGAGCGACTTGACCAGCCACTTGCGGTCCCACACCGGCGAGAAGCCCTACCAATGCGCGGTTTGCAGCTGGCGATTCAGTTTTAAAGGAAATTTGATCAAACATTGCACCATACACACCGgttataagGCCCACACGTGCGAGATTTGTTTGAAAAGCTTCTCTCGAGCAGATTATCTGAAAAGCCATTACGTCGGTGTACATAAAAGGGAAATTGGTATCCGGAAAAGGCGtcaatacaagaaaaaaattgtcgTTAAGTCGAGGTGTGTTTGTAATATTTGCGATAAAGTGTGTCCTTCCAAAACGTCGTTGACATCTCACATGAGGGTGCACAATAGGGAAGATACGTTTAAATGTACAGTTTGTGACAAATCGTTTCGTTATAAAGGTTTGCTGAACGGTCatatgaaaattcatttgaattatcGCCCGTACGCTTGCGGTTTGTGTCCGAAGACGTTTATAAAGCGAAACGATCTCACTCGTCATACCAAGACGCATACCAAAGAGAAAAACTTCAAATGCGAAATTTGCGGCGATAGATTTTCAAGAAAAGACGTTCTCAGATTGCATTTGAGAGGACATACGGGACAGAGGCCtgATGCTAAAACAGTACATAGAACATTTGAGtacaaatattcattcaaaccTCCGTACTTAGCTCAAAAAGACGGCTCAGTACCATTTTGGGAATATGGTGGTAATGCGATTGCTAGTTCTGAAAATGTAAGAATTGCACCTTCTTTAAAAAGTCAAAAAGGTGCTATATGGACAAAACAGCCAATTAATTTCGATTGGTGGGAAGTTGATATTGCTTTTAGAATAACTGGAAGAGGAAGAATCGGAGCGGATGGTTTAGCGTTTTGGTATACCCAAAACAAAGGATCATTTTCCGGCGATATATTTGGATCTTCAGATCAATGGGTCGGTCTCGGTTTGTTTTTTGATTCATTCGACAATGATAACAAACACAATAATCCCTATATCATGGCGGTATTAAATGATGGAACAAAACAATTTGATCatcaaaatgaTGGTACTACTCAACAACTCGCTGGTTGTCTCCGCGATTTTCGTAATAAACCATATCCTACAAGGGCGAAAAtagaatattatcaaaatacacTTACTGTGTTGTTCAATAACGGAATGACGAATAACGAAAAAGATTTTGATATGTGTTTGAGAGCGGAAAACATAGTTTTACCAAGAGGGGGATATTTTGGAATTTCAGCTGCCACCGGAGGCCTAGCCGACGACCACGACGTCATACATTTCCTCACAAAGAGTTTACACCCCATCGAACAATCTCAACAAAATCAAATCGTAGGAGAGGACCAACAAAAACTGCAACAGGAGTATCAAGAGTACCAACAAAAATTGGAAGCCCAAAAAGCGGAATACAAAAAAGAACACCCAGATGAGCGTAAAGACCCCGACGTGGAAGATTGGTTTGAATCAGAGTCTCAAAGAGAACTAAGACAAATATTCCAAggtcaaaatcaaatatacgagGTTCTCAgagaagttaataaaaaaatcgacgaaattgTCGGAAGACAAGAAAGAACGATGAGTCTTATATCACAACAAGCTTCCATGGTTCAAGGAGGAGGAGCTCCACCACCACCACCTGGTATCCCAGCAGCACAAGTTGGGGATACTATTAGGAGACACGAAGTTGACGCTCTTTTCAACAACCACAATCTTTTCAGTGGATATTTACAAGAGATTAAGCAATTTGTGGTGGAATTGAAACTACGAGCCGACACAATTTTAAACAACCAAGCTAAACAACCTACGGCTCAAGTACAATCTGTCGGATATGATACTCAATCTTTGATCAGTGAAATGCGAGACGGACTGAACCACGTCAAACAGAATTTAGTGCAATTATCTCAAAAAGCACCGGCGCAACAAAATTGTCCAGTAGTAACTTGTGTCAATACAACAACGGTCCTTATGATCGCCGCTGTGCAGTTAGCCATAATATTAGCGTATAATCTTTACAgGGATAGCAGAGAGAGCagtagcaaaaaattttattag
Protein Sequence
MKHVVTIKQEIITENLCDHVKSNEALKIEIKEEINDVDDIFEETPEVKTEFFDETESTGEVIEDGECSENVLKMEIGDEGLQYKYEENIPIHCSVCNRSFETTGGLLNHLKRRLRCRYQTKFVAQFWKCFLKKVAKPFKCQVCLKYFSSIYQKDKHTEAHFGKACVACIFCGEYFIKQKEYLQHYRHHSTKQFPIKCKTCPRRFPTKTVYIKHLKTHKDISKNRYRCKKCGSTHSKKSLLLKHTQKEKLNCAYCTKTFCKKSDLTSHLRSHTGEKPYQCAVCSWRFSFKGNLIKHCTIHTGYKAHTCEICLKSFSRADYLKSHYVGVHKREIGIRKRRQYKKKIVVKSRCVCNICDKVCPSKTSLTSHMRVHNREDTFKCTVCDKSFRYKGLLNGHMKIHLNYRPYACGLCPKTFIKRNDLTRHTKTHTKEKNFKCEICGDRFSRKDVLRLHLRGHTGQRPDAKTVHRTFEYKYSFKPPYLAQKDGSVPFWEYGGNAIASSENVRIAPSLKSQKGAIWTKQPINFDWWEVDIAFRITGRGRIGADGLAFWYTQNKGSFSGDIFGSSDQWVGLGLFFDSFDNDNKHNNPYIMAVLNDGTKQFDHQNDGTTQQLAGCLRDFRNKPYPTRAKIEYYQNTLTVLFNNGMTNNEKDFDMCLRAENIVLPRGGYFGISAATGGLADDHDVIHFLTKSLHPIEQSQQNQIVGEDQQKLQQEYQEYQQKLEAQKAEYKKEHPDERKDPDVEDWFESESQRELRQIFQGQNQIYEVLREVNKKIDEIVGRQERTMSLISQQASMVQGGGAPPPPPGIPAAQVGDTIRRHEVDALFNNHNLFSGYLQEIKQFVVELKLRADTILNNQAKQPTAQVQSVGYDTQSLISEMRDGLNHVKQNLVQLSQKAPAQQNCPVVTCVNTTTVLMIAAVQLAIILAYNLYRDSRESSSKKFY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-