Basic Information

Gene Symbol
ZFX
Assembly
GCA_963930735.1
Location
OZ005742.1:250782669-250784985[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 2.2e-05 0.01 18.8 1.9 1 23 236 258 236 258 0.99
2 10 1.2e-06 0.00056 22.8 2.0 1 23 264 286 264 286 0.98
3 10 0.00026 0.12 15.4 1.3 3 23 300 320 299 320 0.98
4 10 3.8e-05 0.018 18.1 1.1 2 23 327 348 326 348 0.97
5 10 1.2e-06 0.00055 22.8 1.6 1 23 354 376 354 376 0.99
6 10 3.8e-06 0.0018 21.2 0.1 1 23 382 404 382 404 0.96
7 10 1.2e-05 0.0056 19.7 0.5 1 23 410 432 410 432 0.96
8 10 2.2e-06 0.001 21.9 0.3 1 23 438 460 438 460 0.98
9 10 0.00046 0.22 14.6 7.1 1 23 466 488 466 488 0.98
10 10 8.3e-05 0.039 17.0 1.7 1 23 494 516 494 516 0.98

Sequence Information

Coding Sequence
ATGCCATTCCTTCAAAATATCCCTGAAGaactaaaattgaataaaatatgcCGAGCATGCTTAGGAGAAAAGGGAGATATGCGTCCACTGTATGGATCGTGCCTAGATGATATGCTACGAGCTGTAGCTCAAGTTAAGGTACAAATTGGCGATGGACTGCCAGAATCTTTGTGTTTACAGTGTGTATTACAAGTAAGCCGGGCATTTCGATTTAAGCAACAATGCGAACGTTCTGATCACACTTTGAGAAATTATATAGGCCAAGAAGAGATACAAATTGACGATAACGACAAATTCATTATTGTAGATTCGACACAAGAGCCAGAGTCAGAACTTGTCCAACATATAACCAATTCTACTCAAGATGATAAATCATGTCTACTGATTTTTGAAGAACTGAATGGTGAACAACAAGATTTATTAGCTGTTGCCACTGGACAAAATAGTGCAGTAATTGAAAACGATGATATCGTCCAGGGTCAGATTAATGCTGCACTTGGGATTGTGCTTGATGAAGAAACCATTAAAATTGAGAATTTTACTGTTCAACATAATGCAGAAAATAGAATACATAGTTCCGAAATATTTTatgaAGATAACATGGAAAGAGATGATGAAATCTTTGAAACTATTCCCTCTGAAGAATGCTATTCTAATGAGAACGACGAAAAGgATCATGAGTTTCATCTCCATCCGACTATAAGTTTTAAGTGTCAGGTCTGCAGCAAAGAGTTTCCAAAACGTCGCATGTGGAGACGACATATGAAAATTCATGATCCAGTTAAACCACACGTATGCAAAGAATGTGGAATGTCATTTACTGAAGGATCGAATctaaaaaaacacataaaaaagcACACTGGAGAACTGAGAAATGTTGTAGGAAAACCGAATTTATGTTCCGTGTGTggTAAAGGTTTTAAATGGGCTAGTTCCTTGTCGAAGCACATGAATCATCATACAAAGAAAAAAATCCTGAATTGCCCCCACTGTCCTAAGTATTATGTGGAAAATAGATCACTTCGAATACATTTAAGAACTCATACAGGAGAAAAACCTTACGTCTGTGATGTTTGTAAGAAAGGATTCACTCAAATGTGTAATCTAGAGAAACACATTAGAGTTCATACAGGTGAAAAACCTTTTTTATGTCCAATTTGTGGTAAGGGATTCTCTCAAAGCGGATATGTTGCTGTTCACTTACGTTCGCACACAGGCGAAAAGCCATACCTTTGTACAACATGTGGTAAAACATTTGCTGGATCAAATTCATTAACAATTCATAAACGAATTCATACTGGAGAGAAACCTTTTGTTTGTAATATTTGTAAGAAGGCATACGGACGTCAGGAATCGCTTGCAATGCATTTACGAACACACACAGGAGAGAAGTCTCACTCATGTTCAATTTGCAGTCGAGGATTCACTTGTTCCAGTCATCTAACAATTCATATGAGAACGCATACAGGAGAGAAGCCATATGTTTGTAAAATATGTTCGAGGAAATTTGTTAGTTTTAATAGTCTTAAGTCGCATGCTAAAAGTCACAAGGATGTACATCAGGCGATAAATCCAAATGAcgttaaattacatttaaaaactGAACACATTAGTGGAGATTGCAATAATCAACAAGAACTAGTACAAAGTACAATTGTAATTGTTCCTGAACAAATTGTACAAGAAGATTCGAAACATTTTTCGATATTAACTCTGaaccaatga
Protein Sequence
MPFLQNIPEELKLNKICRACLGEKGDMRPLYGSCLDDMLRAVAQVKVQIGDGLPESLCLQCVLQVSRAFRFKQQCERSDHTLRNYIGQEEIQIDDNDKFIIVDSTQEPESELVQHITNSTQDDKSCLLIFEELNGEQQDLLAVATGQNSAVIENDDIVQGQINAALGIVLDEETIKIENFTVQHNAENRIHSSEIFYEDNMERDDEIFETIPSEECYSNENDEKDHEFHLHPTISFKCQVCSKEFPKRRMWRRHMKIHDPVKPHVCKECGMSFTEGSNLKKHIKKHTGELRNVVGKPNLCSVCGKGFKWASSLSKHMNHHTKKKILNCPHCPKYYVENRSLRIHLRTHTGEKPYVCDVCKKGFTQMCNLEKHIRVHTGEKPFLCPICGKGFSQSGYVAVHLRSHTGEKPYLCTTCGKTFAGSNSLTIHKRIHTGEKPFVCNICKKAYGRQESLAMHLRTHTGEKSHSCSICSRGFTCSSHLTIHMRTHTGEKPYVCKICSRKFVSFNSLKSHAKSHKDVHQAINPNDVKLHLKTEHISGDCNNQQELVQSTIVIVPEQIVQEDSKHFSILTLNQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00455364;
90% Identity
iTF_00455364;
80% Identity
-