Dfeb017554.1
Basic Information
- Insect
- Dilophus febrilis
- Gene Symbol
- Hsf_2
- Assembly
- GCA_958336335.1
- Location
- OY284472.1:22911573-22914885[+]
Transcription Factor Domain
- TF Family
- HSF
- Domain
- HSF_DNA-bind domain
- PFAM
- PF00447
- TF Group
- Helix-turn-helix
- Description
- Heat shock factor (HSF) is a transcriptional activator of heat shock genes [1, 4]: it binds specifically to heat shock promoter elements, which are palindromic sequences rich with repetitive purine and pyrimidine motifs [1]. Under normal conditions, HSF is a homo-trimeric cytoplasmic protein, but heat shock activation results in relocalisation to the nucleus [2]. Each HSF monomer contains one C-terminal and three N-terminal leucine zipper repeats [3]. Point mutations in these regions result in disruption of cellular localisation, rendering the protein constitutively nuclear [2]. Two sequences flanking the N-terminal zippers fit the consensus of a bi- partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus [3]. The DNA-binding component of HSF lies to the N terminus of the first NLS region, and is referred to as the HSF domain.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 4 2.8e-35 2.2e-31 108.7 0.9 1 100 30 129 30 129 0.96 2 4 0.5 4e+03 -1.2 2.0 62 88 273 300 251 310 0.59 3 4 0.66 5.2e+03 -1.6 1.9 79 89 483 493 413 512 0.60 4 4 2 1.6e+04 -3.2 0.1 71 88 550 567 537 574 0.63
Sequence Information
- Coding Sequence
- ATGGAAGATTCAAAATACTACGATAAAACTTCAGGTGCAGATGATGGTGCTGCTTCTGCTGCTGCAGCAGCAAATAATATACCTGCATTTTTGGGAAAACTTTGGAGACTTGTTGAAAGCACCGCAACCAATCCTTTGATAGCATGGAATTCtCATGGTAATggttttattatcaaaaatcaaacacaattttcaaaacaattattaccattaaattttaaacataataaCATGGCAAGTTTCATTCGACAATTAAATATGTatggATTTCATAAAGTATCATCAATTGATGATGGTTGTTTACGTTTTGATCGTGATGAtattgaattttctcatcaatattttcaaaggggacatattaatttattggaaaaaattaaacgtAAAATTCCACCGGGAAAATTAGCACAAATTGCTGCTGCTGGTGGCGGCACtggtgataataataataatgcattaaCATACGATTCGACGTCGTCGTCGTCCGGTCCATCAATAAAAAcggaaaatgtaaataaagTTTTAAGTGAAGTAAAATTATTACGTGGTCATCAACAATCATTggatacaaaatttacaacaATTCAACAGGAAAACCAAGCATTATGGAGAGAAATAGCTGTTTTGCGACAAAAACatgaaaaacaacaacaaattgttaataaattaatacaatttttagtAACAATTGTACAACCACAACGAAATGCATCCGGTATGAATTGTctaaaaaaacattatcaaTTGATGATTGATGATATACCGGAAAATGAAcgaaaaaggaaaaaattcaatgaaacGACAAAAAGAGAGCACCATCAACTGCAACaccaacagcaacaacaacaacaacaacaacaacaacgtcAACTTCAACATTCAAATCAACAACTACAACAACGATCTGGACCGGTTATTCATGAAGTAAGTGATGAAGAGGTACAAATTGACgatatttatgatgatgattatgacGCTGATGATATTGACATCTCAGAAGCTTTATCACCATATGTTTTATCACCGGGCCCTGATCCTGATGAGAGTTCCGCTGCCGCCGccaccaccatcaccaccagtaatatgaatgaaaaccaacaaattgataatatattggCAACAACAACTAGTAGtagtaacaataataataataatcaaattatcaataataatgatttggATAATAATCAAACagtatatattgatattggCAATGGTGATGGCAACGgttttaatatgaatataaataataataacaataatcaagataaatctaatattatagattacaataatttttatataattgacaATAATGAAATACCTATCGTAAATTATGGATTAGAACAAAATGCATCGATTCCtactattaataataacgtaaatattagcaataataataataatattaataatcaacaacaacaacaagaagaACTACAACAACgccagcagcagcagcaacaacaacaacaacaacaacaacaacaacaacaacaaatacaacCAAAACAAGAATTACAACAATCTTCAAATACATCAtcacaattaaattataatccTCTTATAAACAATCTATCGAATCCAATGGTTTCCGAGGATTTACTTAAAacaaatcaatcaaaattagcccttactaaatataataatacaattaataataataataataatctttataaGCATCCAAATATTATGAGATTAAATTCaagAGAAGAATTAAATGATCATTTGGATACAGTACAAAATAATTTGGATtcaataaaagaatatttacgTACGGATGAATATCCATTCGATCCAAATTCAATATTGAATGTTaATACTACAAATGATACCTCAAAATCATTACTGCCGGTAGATGATTCATAtcaaaattttgataatatggAATTATcagattttttaaatgaaaattcaaacGGAACCAATTTAGCGATTATGCCAATGaatgaAAATTCAATTGGAAAATCAGACGGAACGTTAAATACACCAAAAGTGGAAAAAACTGCATTGTCATTTGATCGAAAATGA
- Protein Sequence
- MEDSKYYDKTSGADDGAASAAAAANNIPAFLGKLWRLVESTATNPLIAWNSHGNGFIIKNQTQFSKQLLPLNFKHNNMASFIRQLNMYGFHKVSSIDDGCLRFDRDDIEFSHQYFQRGHINLLEKIKRKIPPGKLAQIAAAGGGTGDNNNNALTYDSTSSSSGPSIKTENVNKVLSEVKLLRGHQQSLDTKFTTIQQENQALWREIAVLRQKHEKQQQIVNKLIQFLVTIVQPQRNASGMNCLKKHYQLMIDDIPENERKRKKFNETTKREHHQLQHQQQQQQQQQQQRQLQHSNQQLQQRSGPVIHEVSDEEVQIDDIYDDDYDADDIDISEALSPYVLSPGPDPDESSAAAATTITTSNMNENQQIDNILATTTSSSNNNNNNQIINNNDLDNNQTVYIDIGNGDGNGFNMNINNNNNNQDKSNIIDYNNFYIIDNNEIPIVNYGLEQNASIPTINNNVNISNNNNNINNQQQQQEELQQRQQQQQQQQQQQQQQQQQIQPKQELQQSSNTSSQLNYNPLINNLSNPMVSEDLLKTNQSKLALTKYNNTINNNNNNLYKHPNIMRLNSREELNDHLDTVQNNLDSIKEYLRTDEYPFDPNSILNVNTTNDTSKSLLPVDDSYQNFDNMELSDFLNENSNGTNLAIMPMNENSIGKSDGTLNTPKVEKTALSFDRK
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -