Dfeb005053.1


Basic Information
Transcription Factor Domain
Sequence Information
Similar Transcription Factors

Basic Information

Insect
Dilophus febrilis
Gene Symbol
pros_2
Assembly
GCA_958336335.1
Location
OY284468.1:63498954-63506090[-]

Transcription Factor Domain

TF Family
HPD
Domain
HPD domain
PFAM
PF05044
TF Group
Helix-turn-helix
Description
Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. Homologues of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here [1]. This homeo-prospero domain binds to DNA.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3 2.4e+04 -6.6 2.5 67 100 1341 1374 1333 1378 0.64
2 2 1.5e-28 1.2e-24 87.3 2.5 1 50 1847 1896 1847 1896 0.99

Sequence Information

Coding Sequence
ATGATGTCATCAGAGGAGGACACAGACAATTTTGGCTTGTACGGAGATAAATTgttaaagaaaacaaaacgAGCCAGACAGCGCGTAGACGCAGGCGAACCAAGAAATAGTTATTCTTCAATACCGAATTTTAGTTCACGACCTTCCCTCATGAGTGGAGGTCTGTATGGGGCTATTTATAGCCAAAATCAACACAATTTTGGATTATTTAATCCAAACGGTTACGGTACTACAAAAATGTTAAACGAAATATTAGCGCGTCAAGTGAAACAAGCACAAGATGCTACCGGTCcggataatattatattatcatcagcATCTGGATCGTCAGCATCATCGACATCATCCACATCGTCGCTTACAATGGAAAGTgctaatattttaaattcaacgagtgatttattaaataataaaaataattgtaatgtgaataataataataataataatagtgcATATGAAAATGCAACAAATGTTATGCATTCCACATCAACATCACCAACATCGATTTTACGTcgtaatacaattaataataataataataataataataataatgtaattgatttagaaaataattgTATAGGTAGTGGTGGTGTTGGTGGCGGTGGAACTATCGTTGATCCTTCTGCCACATCACCAAATTCAAACGATATAGCACATCATAtgttaagaaatattttacaagGAAAAAAGGAATTGATGGCTTTCGATCATGAATTACGATCGGCTGTTGCTAATCATACAAACctcataaataataataataataataacaataataatattaataataataatacaaataacatcaataataataataataataataataataataaaaatttaaataataaaaatatcggAAGTGATCAAACATCCACAactgataataataattgtattattaaaaatattaacacaaatgataataatatccAAATAAAACAAGAATTGGTTAACGGTGAATCTATAATTagtggtaataataataataatagtggtGGTGATTTAAATGATTCTAGTGAATTGAgtgttaataatattataaatagagtGAATTTAATAAGTGAAAATGGATCACTTGATGAATCATCACAAATTAGTGGTGCAATTTCTCAGGATAGATTTCAAGAAAATAGTAATATTAACAGtattagtaaaaataataataataataataatatgaataataataataataataataataataataataatattaataataataacaatgataataaagaaaataataataattcaaataataataatataattaataataatattaatgataaagatttaatagaaaatgaaatgatttgtTTAAATTCTAGATCAGACTCAGACAATTCTTTACCATCATCACCAGCCGGTTctgatgatgatattttaatcaaaGAGGAAAATATGGATATTGATTTAGATAAACAAAGTGTAACATCcccaattaataataataataataatatgaaccataataataataataataacaataatattaacaattataataataatattaataataataataataatatcataaacaATAAAAGTGAACCTTTTGCTTTGGATATGAAAAAGGCACGTGTGGAAAATATAGTATCCTCAATGCGTTCAAGTCCCGTATTGCAATCACAACAGCAGCAGGTAAATGGTTGTAAAAAACGTAAATTATATCATCCGCAACAACATGATAATAGTGCAGCAGAACGATACGCTGCGGTTGCGGCTGGATTAAATTTAGGCTTACACATACAAAGTTTAATGTTAGACGATGACGATGAAGAAGATGAAGATAATGAGCATCCTAATATTCATCAGAAACGTGTGGAAAAAAGCGCATTGGAATCACAATTACGTTCAATGCAAGAAAAGCTTGCAGAAATGcaacaaaaatatgtacaaCTTTGTAACATAATGGAAACTGTTTCCGATGATAATGGTCACGAAATGGATGATGCAGATAGtgatataattgaaaatgatgatattattgaaaaatctGCAAAAAATTTAGTGGAAGAAAAACAAACGATAGTGTCAGCAGCGTCTCAATCATCAGCAGTACCCGTAACTGCATTGGGATCCACCGCAATGTCACGTTTGTCTTTATCTGTAACTCCACCACCATTGCCATTATCAATATCACCATCGGTAACTCCAGCACCAAGCGCATTACCAACAATAGTCCCTcctccaccaccaccgccaccaccaccaccgccgccACCACCGCTTCCTCCTCCACTACCACACTCATTAACATTACCACTTCCATCAAGCTCTAACCTAACATCAACGACATCTCCATCATCGACATCCTCTATAACAACCCATTTACCAACATTGCCTTCATCACAACCGTTAGCAACGTCACTGTTGTCCTTAAAAGATAACGTACCACCGGCATTTTCTCCACATAAATCAAACGATACTTCCACAATGTTAAATCATGTCATGGGAAAAATGATGACAACAAAATTACATTCACAATTAACTCCATCACAGCTAGCGACCTCGAATGCAGCAATTATTCCTGGACCAACATCCATGCATCATCCACATTCGCAACACATTCCACCAAATTTTAATGGAACTCATCCGTTACTGCAACACATTCAACAACATGGATCTACATTGAATTCTCATGAGCACTTAAATGCCCACGCAAATCCCCATCATCCATTTAATAATGCGGCCGCTGCAATGTATTTGGGGATGGGTCAAAAATTTTTTCTTGATCAACAAGAGGCTCGTGTTAAAAAGGAAACCgaacaacaattacaattacaaaatgAACGATTACattcatcaacatcaacatcatctaCCGTATCGTCATCAGCGACAGCAGCAGCTGGTGCAATAACTCCTGTACCGCCACACCAGTTACCACCACATCATCCACATAATCATCACCATTCACatattcaacaacaacaactaccatctcaacaacaacatcaacaacaacagcagcagcagcaacagcagcagcagcaacaacagcagcagcaacaacagcagctACATCAACATAATCATCATTCAACGAATCATCATCTgcatcaacaaaatattacaaataataacaataccaattctaataatcaaaatttattacaacaaAATCAACACCAATCACAATCGCAAAATTTGcatcatcaacatcaccaACATCAGCAGCAACAGCACCAACAGCAAAttcaacagcaacagcaacaacaacaatcacatttattacaaatgtcaaaaaattcaatattaccAACTGATTTAAGTGAACGTTTAAGTTTATTACGTACAAATGCAAATGCTGTGGGTCCAATGAATGGCACCGATTTGGAAGGTTTAGCCGATATTTTAAAAACGGAAATCACCGCCTCGTTATCAAATTTAGTTGATTCGATTGTTACACGTTTCGTTCATCAACGTCGATTCATTAATAAACAATCGGAAGCGGCTGCAGCAGCTGCTGAACAATTAAATAAGGATTTAATGATGGCCACACAATTATTGGATCGTAAATCACCCCGCACAAAGGTAGCAGATCGTTCgacaaataatttacaatcAGGTAAcattagtaataataataataataataataatcataatactaataataatagtgttattaataatcataataacaacaataatattaatacaaatcTAAATAATGGTTCAATGATAAGTAGttcgaataataataaccatagTACTAATACTAATAATAGTGGTATTGCAAATagtaataattgtaataataacatcattaacaacaataataataataataacaataatattaataataacaataatattaataatagtattaatCAATCAATGAACGCATTGAatcatggtaataatattataaatacaaattgtaATGTTAATCAAAATAGTCAATTGATGAATGGTCCACGTTTGAACAGTAACGCATTTTCTCATTTGGGAATTTCGATGCATTTAAATGGGACATCGtctaatgataatattatgaataataataataataatattaataatagcaataacattattaacaataataattgtaatagtaatataaataattcattgaGTTTACCACCTCATTTACGTCCTTCGCCCACAGCATCAATATTTCAGTCACCAAAACCTCCGCAAGGTATGAATCCAGTTGCAGCCGCCgcattatataattcaataaatatactGAATGGTAGTAGCAACGGTCTTATTGGTGGCAGTACAAGTAATGGAAATAACAGTAATGGTAACAGCGTTGGTGGTGGCAGTGGTGCTGGTAATGGAATTGGGCATTCAAATTCATTGAATCcattttgtttaacaaataatGATACCAGAGATCCACCAACACCGGAACAAAATGAAGCTTTAAGTTTAGTGGTGACGCCAAAGAAAAAACGGCATAAAGTAACAGATACTCGAATTACACCGAGAACAGTCAGTAGAATATTAGCTCAAGATAGTAACATCACAAATTCGTTAACTAATCACATTGATCATCTTACCAATAACAATACcaataatatgttaaataacaacagtaataataacaataataataataacaatcataataataataataataacaacaataattttcattcgaataataacaataataataataataccaacaataataataatagtattacTAATAATACAAATTCGATGAATAACAAATCGTATAATACACAATCAAGTACATCGGCGAATACACCAACAGATAGTCCATCACCTCGATCCGCTTATCATACAGGTTTATTAACATCCTCATCAATACCATCTCATACAACACAATCATCATTATCCTTAAGTCAATCGTCTGTATTACAATCATTATCAAATGGACAcatgcaacaacaacaacaacaacaacatcaatcACATCAACAAAATCAACATTCACCAACGCATCCTCATACACCTCAATCATCATCACAACCGACAACACCTCAATCGTTAGCCGCGGCAACCGCAACGGCAGTCGCCGTATCAACGTCATCGtgtacaacaacaacgacaCCAACATCAACACCTACATCATTATTACCGGTATCGTTACCAACATCCGTTGCAATACCAAATCCGTCATTGCACGAATCACAGGTATTTTCACCGTATAGCCCATTTTTTAATCATCATAGTTCGCATGGTCTACCGCATGCCCCACAAACGGCACAATTACATAATCATATGAAAATGTCATCGAGTCCACCGGGTTTCGGTGGCGGTATGATGGATCCAAGAGATTCACCTCCATTGCCACCCCATCATTCAACAATGTTACATCCAGCATTATTGGCAGCTGCACATCACAGTACATCACCCGATTATGGACTTATGCGTTCATCGATGGACATGAATGATCGTAATTCCGATTGTAATTCAGCTGATATGTCTTTTGATGGAATGCAACAAAACATATCATTTTCAAATGAACAATATTTTCAaaaacaacAAATGATGTCTTTGACATCGGTAAATTCATCGACATTAACACCAATGCATTTACGTAAAGctaaattaatgtttttttggGTGCGTTATCCAAGTTCGGCtgtattaaaaatgtattttcctgatataaaatttaataaaaataatacagcACAATTGGTGAAATGGTTTTCTAATTTTCGGTGa
Protein Sequence
MMSSEEDTDNFGLYGDKLLKKTKRARQRVDAGEPRNSYSSIPNFSSRPSLMSGGLYGAIYSQNQHNFGLFNPNGYGTTKMLNEILARQVKQAQDATGPDNIILSSASGSSASSTSSTSSLTMESANILNSTSDLLNNKNNCNVNNNNNNNSAYENATNVMHSTSTSPTSILRRNTINNNNNNNNNNVIDLENNCIGSGGVGGGGTIVDPSATSPNSNDIAHHMLRNILQGKKELMAFDHELRSAVANHTNLINNNNNNNNNNINNNNTNNINNNNNNNNNNKNLNNKNIGSDQTSTTDNNNCIIKNINTNDNNIQIKQELVNGESIISGNNNNNSGGDLNDSSELSVNNIINRVNLISENGSLDESSQISGAISQDRFQENSNINSISKNNNNNNNMNNNNNNNNNNNNINNNNNDNKENNNNSNNNNIINNNINDKDLIENEMICLNSRSDSDNSLPSSPAGSDDDILIKEENMDIDLDKQSVTSPINNNNNNMNHNNNNNNNNINNYNNNINNNNNNIINNKSEPFALDMKKARVENIVSSMRSSPVLQSQQQQVNGCKKRKLYHPQQHDNSAAERYAAVAAGLNLGLHIQSLMLDDDDEEDEDNEHPNIHQKRVEKSALESQLRSMQEKLAEMQQKYVQLCNIMETVSDDNGHEMDDADSDIIENDDIIEKSAKNLVEEKQTIVSAASQSSAVPVTALGSTAMSRLSLSVTPPPLPLSISPSVTPAPSALPTIVPPPPPPPPPPPPPPPLPPPLPHSLTLPLPSSSNLTSTTSPSSTSSITTHLPTLPSSQPLATSLLSLKDNVPPAFSPHKSNDTSTMLNHVMGKMMTTKLHSQLTPSQLATSNAAIIPGPTSMHHPHSQHIPPNFNGTHPLLQHIQQHGSTLNSHEHLNAHANPHHPFNNAAAAMYLGMGQKFFLDQQEARVKKETEQQLQLQNERLHSSTSTSSTVSSSATAAAGAITPVPPHQLPPHHPHNHHHSHIQQQQLPSQQQHQQQQQQQQQQQQQQQQQQQQQLHQHNHHSTNHHLHQQNITNNNNTNSNNQNLLQQNQHQSQSQNLHHQHHQHQQQQHQQQIQQQQQQQQSHLLQMSKNSILPTDLSERLSLLRTNANAVGPMNGTDLEGLADILKTEITASLSNLVDSIVTRFVHQRRFINKQSEAAAAAAEQLNKDLMMATQLLDRKSPRTKVADRSTNNLQSGNISNNNNNNNNHNTNNNSVINNHNNNNNINTNLNNGSMISSSNNNNHSTNTNNSGIANSNNCNNNIINNNNNNNNNNINNNNNINNSINQSMNALNHGNNIINTNCNVNQNSQLMNGPRLNSNAFSHLGISMHLNGTSSNDNIMNNNNNNINNSNNIINNNNCNSNINNSLSLPPHLRPSPTASIFQSPKPPQGMNPVAAAALYNSINILNGSSNGLIGGSTSNGNNSNGNSVGGGSGAGNGIGHSNSLNPFCLTNNDTRDPPTPEQNEALSLVVTPKKKRHKVTDTRITPRTVSRILAQDSNITNSLTNHIDHLTNNNTNNMLNNNSNNNNNNNNNHNNNNNNNNNFHSNNNNNNNNTNNNNNSITNNTNSMNNKSYNTQSSTSANTPTDSPSPRSAYHTGLLTSSSIPSHTTQSSLSLSQSSVLQSLSNGHMQQQQQQQHQSHQQNQHSPTHPHTPQSSSQPTTPQSLAAATATAVAVSTSSCTTTTTPTSTPTSLLPVSLPTSVAIPNPSLHESQVFSPYSPFFNHHSSHGLPHAPQTAQLHNHMKMSSSPPGFGGGMMDPRDSPPLPPHHSTMLHPALLAAAHHSTSPDYGLMRSSMDMNDRNSDCNSADMSFDGMQQNISFSNEQYFQKQQMMSLTSVNSSTLTPMHLRKAKLMFFWVRYPSSAVLKMYFPDIKFNKNNTAQLVKWFSNFR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-