Doo004722.1
Basic Information
- Insect
- Dicycla oo
- Gene Symbol
- -
- Assembly
- GCA_948252095.1
- Location
- OX411732.1:329553-330482[+]
Transcription Factor Domain
- TF Family
- P53
- Domain
- P53 domain
- PFAM
- PF00870
- TF Group
- Beta-Scaffold Factors
- Description
- P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes [PMID: 20066118, PMID: 12629332, PMID: 1397838, PMID: 6544917, PMID: 19826090, PMID: 19776744, PMID: 6278740, PMID: 221923, PMID: 6318442, PMID: 20030809].This domain is found in p53 transcription factors, where it is responsible for DNA-binding. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilise the protein-DNA complex [PMID: 11780147]. Protein interactions may also serve to stabilise the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability [PMID: 9630226]. The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 11 0.00039 7.6 7.4 1.1 75 113 7 44 2 51 0.76 2 11 0.0015 28 5.6 5.0 63 113 35 84 30 95 0.74 3 11 0.0011 21 6.0 4.8 63 113 55 104 50 114 0.75 4 11 0.00017 3.4 8.6 2.4 62 110 74 121 65 128 0.67 5 11 0.00042 8.2 7.3 2.9 63 112 95 143 90 150 0.75 6 11 0.0003 5.7 7.8 2.2 64 113 116 164 111 171 0.75 7 11 0.0011 21 6.0 2.4 75 113 147 184 142 195 0.72 8 11 0.00015 2.8 8.8 0.6 70 112 162 203 155 209 0.75 9 11 0.0003 5.8 7.8 3.9 58 111 190 242 180 250 0.70 10 11 0.0004 7.8 7.4 5.0 57 112 209 263 199 275 0.71 11 11 0.00021 4.1 8.3 2.9 64 113 236 284 231 304 0.75
Sequence Information
- Coding Sequence
- ATGTCAAGTGAGCCTCACTTAGTGCGGTGTGTACACCGGCGCACAGTTTATGATGGCAACATGTCAAGTGAGCCTCACTTAGTGCGGTGTGTACACCGGCGCACAGTTTATGATGGCAACATGTCAAGTGAGCCTCACTTAGTGCGGTGTGTACACCGGCGCACAGTTTATGATGGCAAGATGTCAAGTGAGCCTCACTTAGTGCGGTGTGTACACCGGCGCACAGTTTATGATGGCAACATGTCAAGTGAGCCTCACTTAGTGCGGTGTGTACACCGGCGCACAGTTTATGATGGCAACATGTCAAGTGAGCCTCACTTAGTGCGGTGTGTACACCGGCGCACAGTTTATGATGGCAAGATGTCAAGTGAGCCTCACTTAGTGCGGTGTGTACACCGGCGCACAGTTTATGATGGCAAGATGTCAAGTGAGCCTCACTTAGTGCGGTGTGTACACCGGCGCACAGTTTATGATGGCAAGATGTCAAGTGAGCCTCACTTAGTGCGGTGTGTACACCGGCGCACAGTTTATGATGGCAACATGTCAAGTGAGCCTCACTTAGTGCGGTGTGTACACCGGCGCACAGTTTATGATGGCAAGATGTCAAGTGAGCCTCACTTAGTGCGGTGTGTACACCGGCGCACAGTTTATGATGGCAACATGTCAAGTGAGCCTCACTTAGTGCGGTGTGTACACCGGCGCACAGTTTATGATGGCAACATGTCAAGTGAGCCTCACTTAGTGCGGTGTGTACACCGGCGCACAGTTTATGATGGCAACATGTCAAGTGAGCCTCACTTAGTGCGGTGTGTACACCGGCGCACAGTTTATGATGGCAAGATGTCAAGTGAGCCTCACTTAGTGCGATGTGTACACCGGCGCACAGTCTCCGCGGTTGCATTGCAATATATCACAGTGATGGTGACGTAA
- Protein Sequence
- MSSEPHLVRCVHRRTVYDGNMSSEPHLVRCVHRRTVYDGNMSSEPHLVRCVHRRTVYDGKMSSEPHLVRCVHRRTVYDGNMSSEPHLVRCVHRRTVYDGNMSSEPHLVRCVHRRTVYDGKMSSEPHLVRCVHRRTVYDGKMSSEPHLVRCVHRRTVYDGKMSSEPHLVRCVHRRTVYDGNMSSEPHLVRCVHRRTVYDGKMSSEPHLVRCVHRRTVYDGNMSSEPHLVRCVHRRTVYDGNMSSEPHLVRCVHRRTVYDGNMSSEPHLVRCVHRRTVYDGKMSSEPHLVRCVHRRTVSAVALQYITVMVT
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -