Basic Information

Gene Symbol
-
Assembly
GCA_949316265.1
Location
OX438913.1:6296098-6309379[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.0033 0.46 12.6 1.9 1 23 416 438 416 438 0.98
2 10 0.027 3.7 9.8 1.7 2 23 446 468 445 468 0.97
3 10 0.00065 0.091 14.9 0.5 1 23 499 522 499 522 0.97
4 10 0.0046 0.65 12.2 0.8 2 23 527 549 526 549 0.95
5 10 4.7 6.6e+02 2.7 0.9 3 21 563 581 562 586 0.91
6 10 2.3 3.3e+02 3.7 0.1 2 23 634 656 633 656 0.93
7 10 0.22 31 6.9 2.3 1 20 675 694 675 697 0.82
8 10 1.4e-06 0.00019 23.3 2.2 1 23 703 725 703 725 0.98
9 10 2.8e-06 0.00039 22.3 2.5 1 23 732 754 732 754 0.97
10 10 4.3e-05 0.006 18.6 1.1 1 23 760 783 760 783 0.94

Sequence Information

Coding Sequence
ATGAAGTGTTGTATAGAAAGCTGTGGAAATACTGGAAAAGGGAAGAAAAGTGCTTCCATTACAGAAAGAATCACTTATCATACTTTCCCAAAAGATCTGGAAAAGCGTGAACTATGGCTGAAATCCCTCGGTATACCAAACTTGGTGCCAACGAGTCGAACACTGGTTTGTTCCGACCATTTCAATGAAGAGGATTTTATCGTTACTCAGAATGGAATCAGAAAGATCAAAGTTGGAAGGGTGCCATGCGTTAAGACCTGTAAACTATGTCTATCATTGAACACCAAgatgtacaaaataaaagatcATGGTTTGGACAAAATGTATCAAGATATCATCGGAATTCCGCCAAGCACAGACCCCCTGAACAGACTCCCAATGGGTATATGTTGGGAGTGCACCGCGCGGCTGCAGTCAGCCTCTGCATTCAGATCTAAAGCGCTTTTCAGCGATGCATTGCTGCAAGATCACCTAAAGACCAACGCCGATCTAACCATCATCGACATAAAAAACATACATGGACAACAAGTTAATTTAAGATCTGGCCTAGCCATACAAGAAGTTTTCAGATTTAATAGTCACAATGGCGAAGAATATGCCCCAAACACTTTTATAAAAACAGAAGTTATAGGCATACCTAACAACGAGGAAATGGAAGTAGACGTACAACACTTAGTAACAGAAAGAATCACTATTAAAGACGAACGAAAAAATGAAGATATTATTGAAAATTGTCCCGACACTGATTTCAAAACCGAAATAGATCTCATTCCTAATAATGAAATCGAGATTCTTGAAGATGAAACATtttttgatgatgatgttgatgcctTTAGTGATAATGATAATATCGAAACAgttattgaaaatgtttttgtcGAAGAATCAAGAAAAGGTGTTGATAAAGTATTGAAAGAGCCTGTAATAAAAAAGATCAATTTTAAGGCTAATTTGGCAGAAATTATGGAGACGAacgatgatgaattgatgaatTTGGCCAAGAATTTTGCAagtgaagatgatgatgacgaagatgaatttaaaataaacctcgTGAATAAGACTGTTAAGTgtgttaaaattaaagaaaggaaGACAAAAACTCGTCCGAAGAAAAAGCAACCTTATGTAAAGCCGCGCATACCAATAGATGAGAATATTTTCTCTATGAAAATACTAAGTGACGAGGACTTGAGACAAGAAATAATCGCCAGACGAGAATCAGAGAAGTATAACATGGCCCCGTTCAAATGTAAAGTGTGCTTCAAAGGATTTGCTACCGGGGACAAGAGAGAAAGGCATATGACTAAACATAGTGAGCAAAGTGGTCCGATAAAATGTAACGTATGCCATGTCCGTATGAAGAAAGCCAGAGAATTGCGCGCGCATATAAAAAGACAGCACACTGAGGAGTTTATATGTAAACTTTGTCCGTTGGTCACTAGGATTCGGAACGTCGCATTAGGACACATGAAGTACCACGCCGGTAACAAGTACGAGTGCCCGCAATGCTCCGTTGAGTTTGAGAAACAGACAACGTTACTAAACCACCTCCGTCTGAAACACATGTCCTCGTGTGTATGTGAACTGTGTGGGTACACGTTCGTTGGTAAGAAAGGCGTGGAGGTGCACAAACGAATGCGGCATAAGTTCTTTGATACTAAAacTGTATTCAAAGGTCCACATTGTGATGTTTGTGACGTGAAGTTCTTGACAGAGAAGGCCTATGACCGACATTTGAGGTTGTCTTCTAAACATATATCGGAGGATGACCCtAACCGTTTAAGTAATGACCCCTCCATAAAGCAGCGGCGGATCGGCGCCGTACCTTATCGCAACATTAGAAGACCAGTCATACATCGTAAGGACAAGAACGCTCCAATAACTACTGGGCCTGTTACTTGTGAACAGTGTGGCATAGAACTGGAAAGTCTTCGTGTATACACGAACCACTTCAGGTACGCTCACCCGGGCGTCAATCGCACGCAGTTCGCGGTCACTACGGGCGCGGGACCCACGCCTTATATGTGCGAGCATTGTGGGAAATTTTTCTtgAATTCAACGACCCTAGCCTGCCACATGTGGGTCCACACTGGACGGAAGCTCTTCCAATGCGATCACTGCAACAAGGCGTTCAGTATGAAATCTAACCTCGCGGGTCACATGAAGCAACATGAAGGCGTACGAAAATTGCATGAGTGTCGCGTGTGCGGGAAAGGCTTTACGTTCAGCTATAATCTTACGAGGCATATGTTTGTACACACGGGCCTCAGGCCGTTCAAATGTGAAGCCTGTGAGAAAACGTTCCGTACATCAACCGAGCTACGCGCACATATCGACCATGTGCATTTGAAGAAACCCAGACCTAAGCGAATCAGACGCAGGGCGAACAAGTGTGATATGCCCACTTTAGAGTATTAG
Protein Sequence
MKCCIESCGNTGKGKKSASITERITYHTFPKDLEKRELWLKSLGIPNLVPTSRTLVCSDHFNEEDFIVTQNGIRKIKVGRVPCVKTCKLCLSLNTKMYKIKDHGLDKMYQDIIGIPPSTDPLNRLPMGICWECTARLQSASAFRSKALFSDALLQDHLKTNADLTIIDIKNIHGQQVNLRSGLAIQEVFRFNSHNGEEYAPNTFIKTEVIGIPNNEEMEVDVQHLVTERITIKDERKNEDIIENCPDTDFKTEIDLIPNNEIEILEDETFFDDDVDAFSDNDNIETVIENVFVEESRKGVDKVLKEPVIKKINFKANLAEIMETNDDELMNLAKNFASEDDDDEDEFKINLVNKTVKCVKIKERKTKTRPKKKQPYVKPRIPIDENIFSMKILSDEDLRQEIIARRESEKYNMAPFKCKVCFKGFATGDKRERHMTKHSEQSGPIKCNVCHVRMKKARELRAHIKRQHTEEFICKLCPLVTRIRNVALGHMKYHAGNKYECPQCSVEFEKQTTLLNHLRLKHMSSCVCELCGYTFVGKKGVEVHKRMRHKFFDTKTVFKGPHCDVCDVKFLTEKAYDRHLRLSSKHISEDDPNRLSNDPSIKQRRIGAVPYRNIRRPVIHRKDKNAPITTGPVTCEQCGIELESLRVYTNHFRYAHPGVNRTQFAVTTGAGPTPYMCEHCGKFFLNSTTLACHMWVHTGRKLFQCDHCNKAFSMKSNLAGHMKQHEGVRKLHECRVCGKGFTFSYNLTRHMFVHTGLRPFKCEACEKTFRTSTELRAHIDHVHLKKPRPKRIRRRANKCDMPTLEY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00446570;
90% Identity
iTF_00446570;
80% Identity
iTF_00447236;