Basic Information

Gene Symbol
-
Assembly
GCA_949316265.1
Location
OX438898.1:17408745-17410730[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.023 3.2 10.0 0.2 5 23 293 311 292 311 0.96
2 12 0.014 1.9 10.7 0.2 3 23 319 339 317 339 0.94
3 12 0.17 23 7.3 0.2 2 23 347 368 346 368 0.94
4 12 5.5e-07 7.7e-05 24.5 1.0 2 23 374 395 374 395 0.98
5 12 0.0031 0.43 12.7 4.3 1 23 401 423 401 423 0.98
6 12 0.00059 0.083 15.0 0.6 1 20 427 446 427 448 0.94
7 12 6.9e-05 0.0096 17.9 0.2 1 23 481 504 481 504 0.96
8 12 0.0012 0.17 14.0 0.1 3 23 513 533 512 533 0.99
9 12 9.4e-05 0.013 17.5 0.5 1 23 544 566 544 566 0.98
10 12 8.2e-05 0.011 17.7 4.5 1 23 572 594 572 594 0.98
11 12 0.003 0.42 12.8 0.3 3 23 602 622 600 622 0.98
12 12 6.5e-06 0.00092 21.1 0.7 1 23 628 651 628 651 0.96

Sequence Information

Coding Sequence
ATGAACTCCGCATACCAGTTCCGTAAACAGTGCATCAAAATGGACAATGAACTACGTTTACAGCTCAATGCTGTATTAGACATATCTAAAAGTGATAATCTCTCTAAATATGATCATAGTGGTGATGACGACTATATTGGGAACGATCCCATGAAGCAACTTGAAGCTATCATTAAACAAGAGCCTACTGATAGTGATGATGATTACTATTATGTCTTGGTTATTGATGACCCCAAAGATAAAGATAAGGATGAACAACCTGAAGTGATCAACATTAAAGAAGAAGCGTATGAAGTAGATGCTGCAATAACTGAGGCTGAAACTACAACTACTTACACTCAACAACCAACTCAAAGCTCTCAAAGCCAGTTTGAGGACTCAATTGAATCCTTCCTAATGTCCAATACAAAAGTCTCAGCTAATGTACCAGCAACTATTCTAGAAAATGAGGAGGAAAGCCAGGAAACTGACGATCTAGCCATGAACATAGATGAAACGCAGGACAGCATGAATCAAGATCAAGACTATGAAATGGAAGATGAACAAGACGATGAAAACATTGAAACTATTACTTCCAATGTTATTAAAGAACTGCCCAATTCGaaaaattacatcaaaatattgACCGCATCAGACTCTGATGGCACTATTTTGTTGAAAGGTAATGACAGGATCCAATACTTGACTGATTCCCAGCTAGTCACAAATGAAGATGAAGATGGAGATGCATTGTCCCAAGAAGTGATATTCTGTGAAGGTGATGACTCTTCTCAGTTCCAAATACTAAAATATGATGGCTCTGAATTGGTTATTGAGTATGCTGATGACAGCCAAATAGCTACAGTACTACAACAAGAGGATGGTACATTCTTATGTGATTGTGGAGAGCAGTTTGAAGACTTAGGTGATTATCAGAAACATCAGTACAAGCACAATCCAGCTGGAGAACATTTATGCAACTTGTGTGGTAAAGGATTTGAGTCTGCAGAGATTTTGACTGGACACATGTTACTTCACAGCAGTACGGGGCTCTTAATCACTTGTCCTTTCTGCAACCAGCCTATAAGACGTAACGCTTTGACACAGCATATCAAGTACGGTCACAACAATATCAAACCTCGCTGCAATGTTTGTTTCAAAACATTTGCCAATCCCAACAACTTGAAACGTCACATGATGATTCACAGCGGCGTCAGAGAATTCGAATGTGACATCTGTTTCAAGAGATTCCACCAAAAAATCACAATGCAAACACATAGGTTAACACACATGAACCCGTTTTCATGTAACCAATGCGAGCAGTCATTTGAGAATAAGACTGCATTGACCAATCACAAAGAATCTGAAGACTGTTCTAAGTCTAAAGTGATTAAGGTCAAAGAAGAATTAATGAAGACGGTCAAGCAAGAAATCACCACAAATCTTGGAAAATTACTTGGTTATGCCTGTTCGCTGTGCAAGAAGATGTTTTCAGTGGAGTCTGCTCTAGAGCAGCATATTGAGAGCACACACATAGTAGATCCAACAGAATTGCTGTGTTCGGAATGCGGTGAAGTGCTGCCATCTAAGAGAGACATGCAAACTCACATTCTGACACATAAGAACATGAAAGTAAAGAATGCAAAGAGGTTTGAATGCAGCCTTTGTGGTAAAGGATGTTCAAGCCAGGCTATGTTACTGATGCATGAGCGAGTACATACAAATGAGAGGCCTTTCCCATGCCAGCTATGTTCTttacgttttaaaacaaaaactcaTTTACGAACACATCAGCTGACTCATACACGGGAAAAGAAATTTGGTTGCTCAGTTTGTATGAAATTCTTTGCCCTCAAAGGGAACTTGGTGGTTCATCTTAGAACACATACAGGGGAGCGTCCGTATGTGTGCTCAATTTGTGGAGAAGCGTTCATAGACTCTAAATACTTGAAGAAACATAAACTAAAGAAACATTCTATAGACAATGTGCCGTGGAATCAGTACTAA
Protein Sequence
MNSAYQFRKQCIKMDNELRLQLNAVLDISKSDNLSKYDHSGDDDYIGNDPMKQLEAIIKQEPTDSDDDYYYVLVIDDPKDKDKDEQPEVINIKEEAYEVDAAITEAETTTTYTQQPTQSSQSQFEDSIESFLMSNTKVSANVPATILENEEESQETDDLAMNIDETQDSMNQDQDYEMEDEQDDENIETITSNVIKELPNSKNYIKILTASDSDGTILLKGNDRIQYLTDSQLVTNEDEDGDALSQEVIFCEGDDSSQFQILKYDGSELVIEYADDSQIATVLQQEDGTFLCDCGEQFEDLGDYQKHQYKHNPAGEHLCNLCGKGFESAEILTGHMLLHSSTGLLITCPFCNQPIRRNALTQHIKYGHNNIKPRCNVCFKTFANPNNLKRHMMIHSGVREFECDICFKRFHQKITMQTHRLTHMNPFSCNQCEQSFENKTALTNHKESEDCSKSKVIKVKEELMKTVKQEITTNLGKLLGYACSLCKKMFSVESALEQHIESTHIVDPTELLCSECGEVLPSKRDMQTHILTHKNMKVKNAKRFECSLCGKGCSSQAMLLMHERVHTNERPFPCQLCSLRFKTKTHLRTHQLTHTREKKFGCSVCMKFFALKGNLVVHLRTHTGERPYVCSICGEAFIDSKYLKKHKLKKHSIDNVPWNQY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00039097;
90% Identity
iTF_00037092;
80% Identity
-