Basic Information

Gene Symbol
PLAGL2
Assembly
GCA_949125395.1
Location
OX421333.1:8953061-8954614[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 9.6e-05 0.013 17.3 3.3 1 23 106 128 100 128 0.97
2 7 9e-05 0.012 17.4 1.8 1 23 134 156 134 156 0.96
3 7 4.5e-07 6.1e-05 24.7 1.8 1 23 162 184 162 184 0.97
4 7 0.018 2.4 10.2 2.0 1 23 191 215 191 215 0.94
5 7 0.00027 0.037 15.9 0.2 2 23 223 244 222 244 0.97
6 7 1.6e-05 0.0022 19.7 1.5 1 23 258 280 258 280 0.97
7 7 1.5e-05 0.002 19.9 1.1 1 23 286 309 286 309 0.94

Sequence Information

Coding Sequence
ATGGCCAGCCCGCCACCGAACCCTAACGAAGGCGAGGAGGGCGGCTCCGAGTTCAAAGAGGAGCCGAGCGGGGAACGCGCGGCCGCCCCGCAGAAGACATTCATAGCGCCGCCCGCATCGCAGCTACCTACGAAGCTGCAATACGTGACGCTCGGCGCCTCCGGTCCCAGCGGCATCAAGCAGTTGTTCCGTACGGTAAAGGTTGCTCGTCGTGTGCCCACGCTGCCGCGCAGGACGAGGGAAGGTGAGGGCGGCGCTGGCCCTTCGGCGCCGCCCGCGCCTGAACCCCGCACGCGCCGCGATCATACTAAGCGTCACAGTTGTGACACTTGCGACAAACGTTTCTCCAGCCCTGGTAAGCTCAGCCAGCATGTCCTCTCCCACACCGGTGAGCTACCTTTCTCCTGTGATTTGTGTGACAAGCGTTTCAATTCCAAGTTCAAGCTTGTACGTCATAATCTTATACACAGTGAGGCTCGAGCCTTCGCATGTGCTGTATGCAATAAGACATTTAATCGTAAGGATCACCTCACTAATCATGTTAGAGTGCACAATCCGGTAAAAAAGCTGTACACCTGTGAAAGGCCTGATTGTAGGAAATCGTATACGTCTCATCTGAGTTATCGCAAACATGCTGCCTTGCATTCGGCTGAAGAAGGCAACCTACAGTGTAAAATATGTGATATGACTTTTGCCACACAGCAGGAAATAGTTTATCATCTAAAAGTTCACACAGGTAGtcgtactgtaaaaaatgatTCTGATAAAAAGTTTACATGCAATTACTGCGGTCGAAAATTCTTTACTGCAAAGGATGTAAGGCGGCATCAGGTTGTGCACACGGGCAGGCGTGATTTTCTATGCCCCTACTGCCCCCAAAAGTTTGGACGTAAAGATCACCTGGTAAGGCATGTTAAGAATGCTCATCCTGATGAGTCGTGGAAATCAGCTGCTGTTGGAACATCAAGCGAGCCGCCTCCCGAGGCCTCAGCATTTGAGGAAACTTACACTGAATACCCAATTGAGGGAACAGAttttgaaatttggaatccaccTTCGCCTAAAGAGAGTACATCAGAAGTAGGTCCAACTAGGGTGCCTTCTACAGATATCATAGTAGAAATTGCACCAGAACTTGATATAAAAGTGGAGCCAATAGATATTAAGCTAGAGCAACCAATAATACCAGATATTAAGTTGGAGGAGCCTGAGTCTCCGAGTTGCTCATTGATACCTGTTGAGTACCCAATGATGTATGTAGTGGCTCCACCTTATACTCAAACACCACCTGACTTGCCTTACATAACAACGGAAGAGCTGTCTGATCCATTACAAGCACATTTGCTCCACCAGGCAAATGTAGAGTCCTTGTTGATGAATCCGGGTGAGGGTCCCTCTGGGTTATCAAGCCAAATGCTAGGTCTGCTAGAGGAGAGTGAACCTACGTATACAGGTGATGAGGGTCGTGTACAACAGCGGCTCCCAGCTTTCACGCAGGCTTTCCAGACAGCACAGAGCCCAAAGCCACCTCCGCCGCCACCCCCGCCCCACTAA
Protein Sequence
MASPPPNPNEGEEGGSEFKEEPSGERAAAPQKTFIAPPASQLPTKLQYVTLGASGPSGIKQLFRTVKVARRVPTLPRRTREGEGGAGPSAPPAPEPRTRRDHTKRHSCDTCDKRFSSPGKLSQHVLSHTGELPFSCDLCDKRFNSKFKLVRHNLIHSEARAFACAVCNKTFNRKDHLTNHVRVHNPVKKLYTCERPDCRKSYTSHLSYRKHAALHSAEEGNLQCKICDMTFATQQEIVYHLKVHTGSRTVKNDSDKKFTCNYCGRKFFTAKDVRRHQVVHTGRRDFLCPYCPQKFGRKDHLVRHVKNAHPDESWKSAAVGTSSEPPPEASAFEETYTEYPIEGTDFEIWNPPSPKESTSEVGPTRVPSTDIIVEIAPELDIKVEPIDIKLEQPIIPDIKLEEPESPSCSLIPVEYPMMYVVAPPYTQTPPDLPYITTEELSDPLQAHLLHQANVESLLMNPGEGPSGLSSQMLGLLEESEPTYTGDEGRVQQRLPAFTQAFQTAQSPKPPPPPPPPH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01333127;
90% Identity
iTF_00636834;
80% Identity
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