Basic Information

Gene Symbol
-
Assembly
GCA_949125395.1
Location
OX421311.1:9548746-9549879[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.029 4 9.5 0.2 3 23 63 84 61 84 0.93
2 9 4.2e-05 0.0057 18.5 0.3 2 23 153 174 152 174 0.97
3 9 0.024 3.2 9.8 0.1 1 23 178 200 178 200 0.97
4 9 0.00027 0.037 15.9 4.9 1 23 205 228 205 228 0.97
5 9 0.44 59 5.8 1.0 2 23 236 258 235 258 0.95
6 9 0.00011 0.014 17.2 2.0 2 23 266 288 265 288 0.95
7 9 4.4e-05 0.0059 18.4 1.9 1 23 294 316 294 316 0.98
8 9 5.7e-06 0.00076 21.2 0.7 1 23 322 344 322 344 0.99
9 9 8.3e-07 0.00011 23.8 2.8 1 23 350 373 350 373 0.97

Sequence Information

Coding Sequence
ATGATCACAATAGAAAGACCTTCAAAACTGAGCGTAGAAGTGAAGTTTATATCAAAACGATCCAGGGTCGACGATAATACAAAGGGTTTTATGTCTGAGACAGCGAAGAACAAGCTGAATTTAACGCATATTTTGCTCAATTCTAACGCCAACCTCATTCGATGTAAAGATAGCCTAGGTTACGGCTGCACATTTTGCCTAAAAAAGTTTCCTGAACCCATCAAACTGAAGAAACATGTCCTCGAAGTGCATAATAACGACAAAGTAATAAAATCTGCAAGAATGTTTGAACATGTCCTCAAGCTTGACATAACTTACTTAAATTGCGCTCTTTGTGATAAAGACATAGAGAAACTCGATGATTTTATGTTTCATTTGAAACATGAACATaagaaaaatatgtacttggatGCCAAAACTCATATCGTTCCCTTCAGATTCGATACATCAGAATTGAAATGCGCTATATGTCCTACAGAATTTAGTTCGTTTAAACTGCTACAGGAACATATGAATTCCCACTTTGGAAATTACATATGTGAAGTATGTGGCGCCGGTTTCGTAACAGACAGACTTAGGATTTCCCACGTCAAGCGCCATGGCAGCGGAGAATTCAAATGCGATCACTGtgataaaacatttaataatcAGACTAAAAGACGAGAGCACGAAAAAAGAGTACATCTTGGTTTCAATGCGAGGAACAAATGTAAATTTTGCGCAGAAAGGTTTGACGATTACTGgaaaaaagtaaaacatatGGTCAAAGATCATGGGGAACCACCGGTTGTTCTTAACTGTACAGCCTGTGATCGTACTTTTAACAACCAGAGATCGTTGTCACGGCACACGAAGAAAGATCATCTTTTGGAGCGAAGACACAAATGCGGCGAATGTGATATGAAATTTTTTGGTAAAAGTAGTTTAGTGAAACACATGGCCAAGCATACTGGTTTAAGGAAATTTAAATGCGACATTTGTTTAAAGGCGTACGGACGGAAAAATACTTTGAGGGAACATATGAGGATACACACTAATGACAGAAGATTCTCATGCACACACTGTGGACAAGCTTTTGTGCAGAAATCCAGTTGGCGGAGTCATATGCGTTCAAAACACGGAGAGCAAGTATAG
Protein Sequence
MITIERPSKLSVEVKFISKRSRVDDNTKGFMSETAKNKLNLTHILLNSNANLIRCKDSLGYGCTFCLKKFPEPIKLKKHVLEVHNNDKVIKSARMFEHVLKLDITYLNCALCDKDIEKLDDFMFHLKHEHKKNMYLDAKTHIVPFRFDTSELKCAICPTEFSSFKLLQEHMNSHFGNYICEVCGAGFVTDRLRISHVKRHGSGEFKCDHCDKTFNNQTKRREHEKRVHLGFNARNKCKFCAERFDDYWKKVKHMVKDHGEPPVVLNCTACDRTFNNQRSLSRHTKKDHLLERRHKCGECDMKFFGKSSLVKHMAKHTGLRKFKCDICLKAYGRKNTLREHMRIHTNDRRFSCTHCGQAFVQKSSWRSHMRSKHGEQV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00157506;
90% Identity
iTF_01360995;
80% Identity
-