Basic Information

Transcription Factor Domain

TF Family: AP-2
Domain: TF_AP-2 domain
PFAM: PF03299
TF Group: Basic Domians group
Description: Activator protein-2 (AP-2) transcription factors constitute a family of closely related and evolutionarily conserved proteins that bind to the DNA consensus sequence GCCNNNGGC and stimulate target gene transcription [PMID: 2010091, PMID: 1998122]. Four different isoforms of AP-2 have been identified in mammals, termed AP-2 alpha, beta, gamma and delta. Each family member shares a common structure, possessing a proline/glutamine-rich domain in the N-terminal region, which is responsible for transcriptional activation [PMID: 2010091], and a helix-span-helix domain in the C-terminal region, which mediates dimerisation and site-specific DNA binding [PMID: 199812]. http://www.ebi.ac.uk/interpro/entry/IPR013854
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 1.3 7.1e+03 -2.5 0.1 139 139 142 142 90 174 0.55

2 3 1.2 6.2e+03 -2.3 0.1 150 150 238 238 197 277 0.55

3 3 2.5e-19 1.3e-15 58.6 0.0 1 41 280 320 280 321 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	1.3	7.1e+03	-2.5	0.1	139	139	142	142	90	174	0.55
2	3	1.2	6.2e+03	-2.3	0.1	150	150	238	238	197	277	0.55
3	3	2.5e-19	1.3e-15	58.6	0.0	1	41	280	320	280	321	0.97

Coding Sequence: AATGTTGACTTGCGCGGATTACAGCATTCTCTTACACCTCAACAACATAGCATGTTTGTGTCCGAACAACAACAACAACATAGAATTCTTCAACAACAAACCACCGTTACTTCAGCAACTGATATTGGACCACAACAACCGCAACAAACTCCTCAACAATTTTCACCATCAAGTACTTCAGAATATACATTTGCAGCGTATAATGGAAGTGGTGCAGATTTGTATTTACAGCCAACTCCTCAACGTTATATTATGTGCTCACATCAAAACCAACAGCAACAACAATTGATTCGAATTCAACAGCGCTATAATACTATTCAACCTCACTACACTAACCAGTCGCAAGAAACTCGAATTGACTATTTAAACAATGTCCTTCCACGCCAATGCTCAGATGTCGAATTTCTACACCATATAAATCAGCAACAACATTGTATACTTCAACAACAAAATGTTGGATTATCGCCACAACAACAGCATTTGTTGAATCAAATGCAACAACAAAGTGGCCATTTTTCTGGAACACCAGCGTCTACTAATTCATTACTTAAAGTGGAAAGCGAGGGAGACCCCTCTTCTGACGAATCAAACGTTGGTGACCATAGTGGCGTAATTCGTAAAGCTAGCCAAGTTCAATCATCTGTTACTGACAGCTCGCTTTTGTCAAACGTTTCTTCTTCTTTTCAAAATATTCATAACAACAATAATAATAACGTAAGTGCCATTCGCAACAGTTCTGTGTTAGGACTTTCATCTTCAGCCCCACAAAGTTCAACTCAATCGGTTAATACAATGTTACAGCAAGAAGCTTCTTCCTTTGTAAATTCAATGCATGTTTTTTGTTCAGTACCAGGTCGCTTAAGTTTACTGAGCTCTGCTGCCAAATACAAAGTTACAGTGGGCGAAATACAGAGAAGAATCAATCCACCAGAATGTCTCAATGCATCTGTTTTAGGAGGAATTTT
Protein Sequence: NVDLRGLQHSLTPQQHSMFVSEQQQQHRILQQQTTVTSATDIGPQQPQQTPQQFSPSSTSEYTFAAYNGSGADLYLQPTPQRYIMCSHQNQQQQQLIRIQQRYNTIQPHYTNQSQETRIDYLNNVLPRQCSDVEFLHHINQQQHCILQQQNVGLSPQQQHLLNQMQQQSGHFSGTPASTNSLLKVESEGDPSSDESNVGDHSGVIRKASQVQSSVTDSSLLSNVSSSFQNIHNNNNNNVSAIRNSSVLGLSSSAPQSSTQSVNTMLQQEASSFVNSMHVFCSVPGRLSLLSSAAKYKVTVGEIQRRINPPECLNASVLGGI

Sequence clustering based on sequence similarity using MMseqs2