Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 1e-06 0.00026 23.9 3.7 1 23 116 138 116 138 0.99

2 6 6.9e-06 0.0018 21.3 1.6 1 23 144 167 144 167 0.95

3 6 0.00012 0.031 17.4 1.0 1 23 173 196 173 196 0.95

4 6 8.5e-06 0.0022 21.0 1.1 1 23 204 227 204 227 0.96

5 6 0.018 4.6 10.6 4.9 1 19 235 253 235 258 0.93

6 6 1e-05 0.0027 20.7 0.4 1 23 266 288 266 288 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	1e-06	0.00026	23.9	3.7	1	23	116	138	116	138	0.99
2	6	6.9e-06	0.0018	21.3	1.6	1	23	144	167	144	167	0.95
3	6	0.00012	0.031	17.4	1.0	1	23	173	196	173	196	0.95
4	6	8.5e-06	0.0022	21.0	1.1	1	23	204	227	204	227	0.96
5	6	0.018	4.6	10.6	4.9	1	19	235	253	235	258	0.93
6	6	1e-05	0.0027	20.7	0.4	1	23	266	288	266	288	0.98

Coding Sequence: ATGGCATCTTCAGAAAAAACAGCAAATACTTTCACCCAACAAGTGTCTCCAGAATTCAAGATCTACGAGATGAAAAACAAAGTAGGGAAATATCCGAGAAAATCTTCTCCTCAAATTACAAACGCCATTTATGATAATAAAATCGCCCAATGGAATAAACTCTCAGATGAAGAATTAGCCAATAAACGCCTTTATGTTGATTTAACCCAAAGGCGCCCAGAAATTCTTAATAATCCCCTATTTCAAACTAAGGTAATAACAACAAGAAGTACAGATGaaaagaaaattgaagataatttTGTTGAAGAGAAGACTGTGAATTTTGAGTACCAGGGAGAATCTCAGTTTAAATGTGAAACTTGCTTCAAGCCCTTCTcaaaaaaatcttatttacaaCGTCATCAAAAAGTACACGCCAATgatgaaaaatttaaatgtttattGTGTTTAAAAACTTTTGCCGATAATTCTAACCTAAAAAGACATTACTTATACTTACATAGTGGGAATAAGATGTTCAAATGTACAATCTGTGCCATGACCTTTGTAGAAAATTCTGGTCTAAAGAGGCATTATCTTTATAAACATAGTAATGAAGAGGAAAAAAGGTACAGGTGTAAGATATGTTCCAAGAAATTCGTAGAAAATGGAGGCCTTAAGAGGCATATTTTGTACAAACATAGTGGTGAAATAGGTAAGAGGTATAAGTGTACTATTTGTTCGAAACAATTCGTGGAGCATTGGATGCTGAAAAGGCATTGTTTGTACAAGCATAGTGGGGGTATGGGTAAGAGATTTAAGTGTAGAATATGTTCTAAAGAATTCGTCGAAAATGGCGGACTCAAACGACATTTAAATGTACATTTATAA
Protein Sequence: MASSEKTANTFTQQVSPEFKIYEMKNKVGKYPRKSSPQITNAIYDNKIAQWNKLSDEELANKRLYVDLTQRRPEILNNPLFQTKVITTRSTDEKKIEDNFVEEKTVNFEYQGESQFKCETCFKPFSKKSYLQRHQKVHANDEKFKCLLCLKTFADNSNLKRHYLYLHSGNKMFKCTICAMTFVENSGLKRHYLYKHSNEEEKRYRCKICSKKFVENGGLKRHILYKHSGEIGKRYKCTICSKQFVEHWMLKRHCLYKHSGGMGKRFKCRICSKEFVENGGLKRHLNVHL*

Sequence clustering based on sequence similarity using MMseqs2