Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 1.3e-09 8.8e-07 31.8 0.2 2 23 24 45 23 45 0.97

2 6 3.1e-07 0.0002 24.4 1.7 1 23 51 73 51 73 0.97

3 6 1.2e-06 0.00081 22.5 3.2 1 23 79 101 79 101 0.98

4 6 3.1e-07 0.00021 24.4 0.2 1 23 107 129 107 129 0.96

5 6 5.7e-06 0.0038 20.4 0.5 1 23 135 157 135 157 0.97

6 6 0.00012 0.083 16.2 1.7 1 21 163 183 163 184 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	1.3e-09	8.8e-07	31.8	0.2	2	23	24	45	23	45	0.97
2	6	3.1e-07	0.0002	24.4	1.7	1	23	51	73	51	73	0.97
3	6	1.2e-06	0.00081	22.5	3.2	1	23	79	101	79	101	0.98
4	6	3.1e-07	0.00021	24.4	0.2	1	23	107	129	107	129	0.96
5	6	5.7e-06	0.0038	20.4	0.5	1	23	135	157	135	157	0.97
6	6	0.00012	0.083	16.2	1.7	1	21	163	183	163	184	0.93

Coding Sequence: ATGCGTCTTCAAGACCAAGAGCGACCTCTGGATCTTACGAAGCACACTGTTATAGGGAAGCACGTGTTGCCATGTGGAGAGTGCGGCAAAGTTTTCGACCGACCCTCTCTGCTCAAACGACACATGCGAACTCATACAGGAGAAAAGCCGCATGTGTGTGAGGTGTGTTCCAAGGGATTCTCGACCTCCAGCTCTCTCAACACACATCGTCGAATTCACAGTGGAGACAAGCCTCATCAGTGCAATGTTTGTGGGAAACGTTTCACGGCCAGTTCTAACCTCTATTATCATCGCATGACTCACACCAAGGAAAAACCCCATAAATGTGGACAGTGTGGTAAATCCTTTCCAACTCCTGGAGATTTGAAGGCGCATGTGTATATTCACACCGGGGCTTGGCCTTTCAGATGTGTGGTTTGCAACAGAGGTTTCAGCAAAGCAACCAATTTAAGAAATCATGTCATGTTACATTCAGGAGAGAGGACATTCGAATGCCAACGTTGCGGCAAACGCTTCTCGCTCGCGTGCAATCTGCGAGCGCACAACAAGAGCGGATGTGACACGAGACAGCAGCTAGCGTCTACAGAGGTGCCGGCTCCCAGACCACAATGTGGAGATCCTCGTCTGCAGCAATGCATTCTGTGCTCTATGGTGGCAGAGAGTGTAGTTCCAGCCAAGGATGGTGTTCTACGTGTCCTTGATCTGTGGTCCTTGTCAGCATCCCTGCCTTTGGATATGAGAGCTCTACTACTCATACAGGCTGCCAATGCCTCCAAGGCCTGGAATGTACAGCCAATAATGCAATAG
Protein Sequence: MRLQDQERPLDLTKHTVIGKHVLPCGECGKVFDRPSLLKRHMRTHTGEKPHVCEVCSKGFSTSSSLNTHRRIHSGDKPHQCNVCGKRFTASSNLYYHRMTHTKEKPHKCGQCGKSFPTPGDLKAHVYIHTGAWPFRCVVCNRGFSKATNLRNHVMLHSGERTFECQRCGKRFSLACNLRAHNKSGCDTRQQLASTEVPAPRPQCGDPRLQQCILCSMVAESVVPAKDGVLRVLDLWSLSASLPLDMRALLLIQAANASKAWNVQPIMQ

Sequence clustering based on sequence similarity using MMseqs2