Basic Information

Gene Symbol
-
Assembly
GCA_012273795.1
Location
CM022556.1:1598479-1621409[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.015 1 10.3 0.2 1 23 252 275 252 275 0.95
2 12 5.7 3.8e+02 2.2 0.2 2 23 283 304 282 304 0.91
3 12 0.77 50 5.0 0.8 1 19 308 326 308 329 0.84
4 12 0.002 0.13 13.1 0.2 1 20 337 356 337 358 0.94
5 12 0.0047 0.31 12.0 1.0 2 21 365 384 365 385 0.92
6 12 0.00055 0.036 14.9 0.6 2 23 401 422 400 422 0.94
7 12 0.00011 0.0074 17.0 0.5 1 23 427 449 427 449 0.98
8 12 0.00018 0.012 16.4 5.3 1 21 458 478 458 483 0.94
9 12 0.0058 0.38 11.7 2.0 1 23 491 514 491 514 0.89
10 12 0.0068 0.45 11.5 0.1 1 23 520 543 520 543 0.93
11 12 0.0048 0.31 11.9 0.9 3 20 556 573 554 577 0.91
12 12 0.0019 0.12 13.2 0.8 1 23 587 610 587 610 0.98

Sequence Information

Coding Sequence
atgaaagaaattaaCATAAACATCGAAGGATACAATGTCAATGGCATTTGCGTTGGCTGCTTGCATTTTAAACGTAAAATGTACTATCACGACGATATAAAAGAGTTCTACAAAATTATAGGAAATATCGATGTTCCAGATGGTCTAGACATTCAGCTCTGTTGGGAATGTTATGCTGCAGTGAGGAAAATGAAAGAGTTTCAACAGAAAATAGTGAAGTCATATGAATTTCTTATTAATTACTCTATGCatTCTCCGTTCCTGAACTCTCCTGAAGATTTCACGAAGCATGCTGTCTCAAGCTTAAAGATATCAGAAACTGATATCCATTCATGTGGAGTTGCCAGTGAGAGCAATATTGACCCAGTTTCGGAAATTAAGGAGGATATCAAGGATGAAATAGACATTGAGTATGaatTATTACCGGTCAAAGAAGAACCGGACATATCGCAAGACTCTCAATTCTCTGATGACATGTTCCAAGACCCCGAAGTCACGTCTGAGGATGACATTCAACTGTCGaagctgaagaagaagaaggtcAAGAAAGAGAAGAAGAGTAAGAAGAAGGGGAGGAGGAAAGAGAAAGATTCGGAAGAGACGATCCAAGCAGATCAGCCGCCACCGGACAAAATCAGTCGTAAGCTAAAGAATCTGCCACCGGACCTGGTGGAAATCTACACGATGTCGGAGGAGGAGATGTGGCAGATACGTTATCAGGACGTGTGCAGTAAGGAGTTCACGAAGTTGAAGTACAGGTGCGATGACTGCGTCATTGCTTTCAATACTTCCAAGCTGAGGGAGGAACATCTCAATGGGAAACATAAGAATaaaGGCGACGGTTCCCAATGCGATGTGTGCAAAGCCTATTTCCTAGTCAAAGACAATATATCCGCGCATAGATCTCTGCACGCGGCTGCATATAGGTGTAAGGAGTGTGATATGAAGACCACCCTCAAACGGGTAATGGCCAAACATGGCTGTATACAAAAGAGAAATTCCGAAGAGTACAGTTGCGCCACCTGTGGGAATATTTTTAGTACGAAATCAAAACTGTCGTACCATAGGATAGTGTGCGACCAAGAGCGGCCGCAGTGCGACTGCTGCGGGAAGGTGTTCGCGAACAAAATGACACTCAAGTATCATCTCAAAATTTTACCCCAAAACAAAGACGAGAAGACGAAAGAGAAAGTCGTGATACCCTGCAAAGGATGCGAGAAGGTGTTTCATTCCAAGAAGAGTTATAGGGCGCATGTTGTAATACACGACGGTCTAACTTACCCGTGTCAAGTGTGCGGCAAGTTGTTCCAGTGGAAGCGTAACTTGGCCCGCCATATGCGGAACCATCGGGAGAGGGACGCCGGAGCACTGCACGAGTGTAGGGAGTGCGGGAAGACATTCTCTAGCCGAGACTGCTATAATAATCATATGAAACTCAGCAAAAAACATGCCACGGAATTGACTTATGCCCACGAGTGCAACTTCTGTGGCAAGAAGTTCccgactaagtggtgcatggtGGACCATGTAGACTGGGATCACCTAAAACGTATTAAGTATAGATGCGGCATTTGTTTTAaggcaTTCAAAACGGCGAAAATAATGGTCGCCCacattaataatatacacaAGGATAAGAAAAAAGAAGTGGACGGCGAACATTTATGTGAAATTTGTGGCAAATCATATAAGACTGTGAAGAGACTGAAGAGTCACGTGTGGTCGATGCACACAAACCGGGCGACCAGCAAGAACACGTACACCTGCAAGATATGCCCGGCCACCTTCACGTGGCAGACCTCCATTTACAAGCACATGAAGATGATGCACGACACGAAACGGAATAAGAGTAATAGAGCGCCGTCGGTGTACAAAAAGCAGGAGTCCTATAATGACATTAAGCTTCCTAATCCAATGGAATATTTCCAACCGAATATAACCAATAATTTAACACAGAACATCAGTTTATTGTAA
Protein Sequence
MKEININIEGYNVNGICVGCLHFKRKMYYHDDIKEFYKIIGNIDVPDGLDIQLCWECYAAVRKMKEFQQKIVKSYEFLINYSMHSPFLNSPEDFTKHAVSSLKISETDIHSCGVASESNIDPVSEIKEDIKDEIDIEYELLPVKEEPDISQDSQFSDDMFQDPEVTSEDDIQLSKLKKKKVKKEKKSKKKGRRKEKDSEETIQADQPPPDKISRKLKNLPPDLVEIYTMSEEEMWQIRYQDVCSKEFTKLKYRCDDCVIAFNTSKLREEHLNGKHKNKGDGSQCDVCKAYFLVKDNISAHRSLHAAAYRCKECDMKTTLKRVMAKHGCIQKRNSEEYSCATCGNIFSTKSKLSYHRIVCDQERPQCDCCGKVFANKMTLKYHLKILPQNKDEKTKEKVVIPCKGCEKVFHSKKSYRAHVVIHDGLTYPCQVCGKLFQWKRNLARHMRNHRERDAGALHECRECGKTFSSRDCYNNHMKLSKKHATELTYAHECNFCGKKFPTKWCMVDHVDWDHLKRIKYRCGICFKAFKTAKIMVAHINNIHKDKKKEVDGEHLCEICGKSYKTVKRLKSHVWSMHTNRATSKNTYTCKICPATFTWQTSIYKHMKMMHDTKRNKSNRAPSVYKKQESYNDIKLPNPMEYFQPNITNNLTQNISLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00432574;
90% Identity
iTF_00432574;
80% Identity
-