Basic Information

Gene Symbol
topi
Assembly
GCA_027574845.2
Location
JAODFZ020034054.1:63-2021[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.00039 0.038 14.8 2.4 2 21 134 153 133 154 0.94
2 10 7.2e-07 7.1e-05 23.3 0.6 1 23 179 201 179 201 0.97
3 10 0.025 2.4 9.1 2.2 3 23 209 229 208 229 0.95
4 10 0.56 55 4.8 0.2 2 12 248 258 247 266 0.83
5 10 2.8e-05 0.0028 18.3 1.3 2 23 332 353 331 353 0.97
6 10 0.14 14 6.7 0.0 1 21 359 379 359 380 0.91
7 10 0.042 4.2 8.3 3.6 2 22 396 416 395 419 0.87
8 10 0.0085 0.84 10.5 0.2 1 23 550 573 550 573 0.96
9 10 0.0065 0.64 10.9 0.4 1 23 577 599 577 599 0.97
10 10 7.6e-06 0.00075 20.1 5.4 1 23 605 627 605 627 0.98

Sequence Information

Coding Sequence
ATGAATAGAAATGATCAGATTGCCTATTTAAAACTACATAGAATACATGCCGGTGGTCAAGTACAATCAATGCAATTGAAAGTAGATTGCAAAGCACAGAAAACAGTTGCAAGGCTTCCAATTCAAGCAGAAGTATTATCGATGTATACCAATATTGATTTCGGAGCGAAATCTGAAGatgattttcaattcaattataccATGAATTTCAACGATTCGACGATTCGCGTCGTCAAATTGGGAGGTATTGAAGATTTGAATCCACTAAACTTCGCCTCGGAAATATCGTCGATATTAAGTGAACAAATCGAGTCGAAACCGAGTTCACCTCAGTCTCCAGAAGAGTCTCCAGGGGTACCAAAACGTGATAGCAAAGTCCCAAACATTCCAACGATGATACGATGCCAAAATTGTGATACAAACTTTCCGACCAAATACCAGTTTCAACGGCACCAATGTGAATTTAATGCTGAGAAAGTCGTATTGAAACCGAATTTGGATGTAAGGGATGTCGAGAAAGGCGTTCGCATGAAATTTGATTGTCCTACGTGTGGTAAGCAATTCGTAAGCAGAAATAATCTAGAGCGACATCTAACCAGCCACGATGAAGACAATATAAACATCTGCGAGTTTTGCAACAAGCATTTTGTAAGCGAAAATCGTTTACGCATTCACAAGGAGAATCATTGCAAGAAAGCAGGTGACATATCCAAATTCTATCGTAGCGATGTGACTGTATGGAAATGTGTGAAATGCCATCAAGTTTTTTCATCGGACGTATATGCCAGCTCACATGCCGAAGCCTGCAACGATATCTTGGACATGGAACAATTCAAAATGTATTCTAGCCAGGAGCCTGATGATGAGCATTTGAAGCGTGAAATCAAGACGTTATTGAATGAAGCACCTGAATTAGCAGTAGAAGGTGAAATGGCGACAATTAACCtaacttattttaaatttattcaaaaaattctaaCCGAACTTTTATTGCAATGTGAATTTTGCAATAAGACGTATGCTGATAAGAAATCATTATTGTTGCATCAAAAGTCGCATACGACTGATGTTAACTATAACTGCGTTGTGTGCAACGTAACATTTGATTCTTATGCACAGGCTGCTAAGCATTGGCTCACAAAATGCTCCAACGaaggaaatttgttttttttgccTAAATTAACCTATTGCCGTTATTGCGATAGAACTTTTAAGTCGCATGAAGTCTTATATtcgcataaaattaaaaagaagcATTACACACCAAAAAAGTACGTTAGTTATGAAATTCCTAAAGctgaaattaaagaaatgcCTCCAGTACAAAAGGAGGAAGATAAAGAaacgataataaaattaattgaagatgttttatgttcaataaaactaaatgagaagGATAAAAATAAAGGCACATCGGAACATGATCATAAGGAAACTAAATATAGTAATCAAATTGACGATTTAACTTCTGTTACAATTAAAACAGAAGTGATGAGTGAGCCAAGTAGTTTAATTATTCCTAAAGAAATACATGAAGCTGAATTGGTCATCTCTGGTAAGAAAAAGCGTGGAAGGAAGCGAAAACATATGGCGCAGTCGAATAAAGTTAAGCGTTTAGCTCTGAATGTTGATCCAGGTTATAAGTATCAATGTGAGCGATGTGTGCGTGTATTTGATACCGTCTTAGATTTGGAATCACATCGTGATAAAGATCATCCAGCCAATTATAAATGTGAAGAATGCGAACAggTGGTGCATAGTTCTAAAGCGTTACTGATACATAGTCGTGCTCATCAAAGCCTTAAGCCCTATGTGTGCGAGATTTGTAAAAGATGCTACTCACAGACGTCCCATTTATGGCAGCATATGCGGTTCCATCAAGgtaggtattaa
Protein Sequence
MNRNDQIAYLKLHRIHAGGQVQSMQLKVDCKAQKTVARLPIQAEVLSMYTNIDFGAKSEDDFQFNYTMNFNDSTIRVVKLGGIEDLNPLNFASEISSILSEQIESKPSSPQSPEESPGVPKRDSKVPNIPTMIRCQNCDTNFPTKYQFQRHQCEFNAEKVVLKPNLDVRDVEKGVRMKFDCPTCGKQFVSRNNLERHLTSHDEDNINICEFCNKHFVSENRLRIHKENHCKKAGDISKFYRSDVTVWKCVKCHQVFSSDVYASSHAEACNDILDMEQFKMYSSQEPDDEHLKREIKTLLNEAPELAVEGEMATINLTYFKFIQKILTELLLQCEFCNKTYADKKSLLLHQKSHTTDVNYNCVVCNVTFDSYAQAAKHWLTKCSNEGNLFFLPKLTYCRYCDRTFKSHEVLYSHKIKKKHYTPKKYVSYEIPKAEIKEMPPVQKEEDKETIIKLIEDVLCSIKLNEKDKNKGTSEHDHKETKYSNQIDDLTSVTIKTEVMSEPSSLIIPKEIHEAELVISGKKKRGRKRKHMAQSNKVKRLALNVDPGYKYQCERCVRVFDTVLDLESHRDKDHPANYKCEECEQVVHSSKALLIHSRAHQSLKPYVCEICKRCYSQTSHLWQHMRFHQGRY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00430028;
90% Identity
iTF_00430028;
80% Identity
iTF_00430028;