Basic Information

Gene Symbol
ZEB1
Assembly
GCA_905220455.1
Location
LR999998.1:4657802-4671340[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.0011 0.08 13.8 2.3 2 23 258 280 257 280 0.94
2 11 0.016 1.2 10.1 6.2 1 23 286 308 286 309 0.94
3 11 1.1 79 4.4 0.8 1 23 313 335 313 335 0.97
4 11 0.0024 0.17 12.8 2.5 1 14 339 352 339 363 0.79
5 11 2 1.4e+02 3.6 0.0 2 21 386 405 385 406 0.87
6 11 1.2 89 4.2 0.2 3 23 416 437 416 437 0.90
7 11 2.5e-06 0.00018 22.1 2.5 1 23 441 464 441 464 0.95
8 11 0.0012 0.087 13.7 0.2 3 23 491 511 490 511 0.97
9 11 4.2e-06 0.00031 21.4 0.1 1 23 517 539 517 539 0.98
10 11 0.0012 0.086 13.7 3.0 1 23 545 567 545 567 0.98
11 11 0.0023 0.17 12.8 0.0 1 23 573 596 573 596 0.91

Sequence Information

Coding Sequence
ATGTGGTCCGTTTCTCAAAACATTGATTTTTCGCCAAAAGACGAAGTTAAAAGTGAACTTTTGACTTGTCGGGGCTGCCTTGGCACTGGGCGGCTGTACAACATGACCCAGTACGGGCTGGCAGAGCCCTACCAGCAGTTGGTTGGTGTTGAGGTAAGAGACACCGCCATCCTTCCGCAGCATCTGTGCCAGTTATGTCGAGCCCTGGTGCTCAAGTTTGTGCAGTTTAGAGAGAGATGTCGCCGAGCAGAGATGCTGCTGCAAAACCTCACCATGCTGGCTCCAGTGGTGACGTTAGAAGACATAGCTACCATAGACCGCTCAGCCGAGCAGCTAACACCTCCATACACACACACCACAACAAACATAGTGACATGCTCCGAACAATTTGAAATCGAGATCGAACCGCCTGTCGAACCACAAGAGTTCCCAGATGACTTCAAACAGGACAATTCAGATATTGATGTTAAAAGCAACATGGATTTGGACTTCGCAGAACCGATTTTTGAAGAGGAGGTTCCAGTTAAAAAAACTAGGAAGAGGAAAGGTAAAAAGGAAGTAATTAAAGATGACAGTGAAGTCAAGGAAGAGAAAGTTAAAAAAGCCAGGAAGAATGCTAAGCCACGAGTCAATAATTTGTATACGGATCCTGAAGACAGGTTGAAATTCTCCCAGAAGTACGACGTGGATATAATAGTGATGTCTCGCGAGGACGAGGTGGCGGACATGCTGCAGCGCGCGAGCAGCGCCCGCTACCTGCGCGCGCACAACAAGTGCGAGCAGTGCTACAAGGGCTTCATACACGAGGACACGTTGAGGAGACACGTCAAGGACAAGCACGACCCGAGCATGGAGCACGCGTGCGAGTTCTGTCGGTTCCGGTTCAGCAAGCGCGTGAACTTGACTGGACATTACCGGAGACACCACAAGTACAAATACGTGTGTCGCGTCTGCAGTGTTGTCACGAGGATGAGAGAGCACGCGGTGCAACATTCAAAAATGCACACTCAGAAATTTGAATGCAAATACTGCGGGAAGACTTTCAATACCAAGGGCACGACGTACCACGCGCACGTGCGCTCGCAGCACAGCACGGAGCTGGCGTGGTGCCGCGTGTGCGGCGACGCCTTCACTCTAATCCCCACCCCAGAGCTTCAATGCCCCACATGCAGCACTCAGTTCCTGTCCACCGCCGCGCTGGGGGTGCACATGTCGCGCGGGGTGCAGTGCTCCACGCTGCAGTGGTGTCTGCACTGCGGTCACGGGTTCGATGCCGACGCCGCGCTGAGGGAACACGTGTTGGCTGTGCATAAAGTGCAATATCCGTGCCAGAAGTGCAACAAGGTGTTCAGCCACGAGAGCAAGCTGAACAACCACATGCTGGAGAAGCACAGCGAGGAGGCGGGGGCTGCGGGGGCGGGGGCGGAGGCGCGCGGACGCAAGCGCTACATGAAGGTGGTGCCCGCCATGTGCGACGTCTGCGGGAAGATCATCGCGGATCAGTACCACATGGTGTATCACCAGCGCATCCACACGGGGGAGAAGCCCTACGCGTGTGCCGAGTGCCCCAAGAGATTCCGTATGCCTGAACAACTGCAGAACCACGTGCGGATCCACACTGGCGAGCGGCCGTTTAAGTGCAAGTACTGTCCCAACACATTCAAGACATACCCCGCCATGAGCAGACATCACCTGGTACACACGGGCGTGCGGCGCCACGCGTGCGCGGCGTGCGGCAAGGCCTTCGCCACCGCGGCCGAGATGAAGACGCACGCGCGCGCCGTGCACATGAAGCACCCGCCCGCGCGCCCGCGCCGCCGCCGCGCCGCGCCCTGA
Protein Sequence
MWSVSQNIDFSPKDEVKSELLTCRGCLGTGRLYNMTQYGLAEPYQQLVGVEVRDTAILPQHLCQLCRALVLKFVQFRERCRRAEMLLQNLTMLAPVVTLEDIATIDRSAEQLTPPYTHTTTNIVTCSEQFEIEIEPPVEPQEFPDDFKQDNSDIDVKSNMDLDFAEPIFEEEVPVKKTRKRKGKKEVIKDDSEVKEEKVKKARKNAKPRVNNLYTDPEDRLKFSQKYDVDIIVMSREDEVADMLQRASSARYLRAHNKCEQCYKGFIHEDTLRRHVKDKHDPSMEHACEFCRFRFSKRVNLTGHYRRHHKYKYVCRVCSVVTRMREHAVQHSKMHTQKFECKYCGKTFNTKGTTYHAHVRSQHSTELAWCRVCGDAFTLIPTPELQCPTCSTQFLSTAALGVHMSRGVQCSTLQWCLHCGHGFDADAALREHVLAVHKVQYPCQKCNKVFSHESKLNNHMLEKHSEEAGAAGAGAEARGRKRYMKVVPAMCDVCGKIIADQYHMVYHQRIHTGEKPYACAECPKRFRMPEQLQNHVRIHTGERPFKCKYCPNTFKTYPAMSRHHLVHTGVRRHACAACGKAFATAAEMKTHARAVHMKHPPARPRRRRAAP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00428458;
90% Identity
iTF_00428458;
80% Identity
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