Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 7.5e-05 0.0061 17.6 2.8 2 23 62 83 61 83 0.96

2 6 1.3e-08 1.1e-06 29.4 0.8 1 23 89 111 89 111 0.98

3 6 1.1e-07 9.1e-06 26.5 0.6 1 23 117 139 117 139 0.98

4 6 2.4e-05 0.002 19.1 0.1 1 23 145 169 145 169 0.98

5 6 0.00087 0.072 14.2 2.0 1 23 179 202 179 202 0.96

6 6 0.016 1.3 10.3 0.2 2 23 217 238 217 238 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	7.5e-05	0.0061	17.6	2.8	2	23	62	83	61	83	0.96
2	6	1.3e-08	1.1e-06	29.4	0.8	1	23	89	111	89	111	0.98
3	6	1.1e-07	9.1e-06	26.5	0.6	1	23	117	139	117	139	0.98
4	6	2.4e-05	0.002	19.1	0.1	1	23	145	169	145	169	0.98
5	6	0.00087	0.072	14.2	2.0	1	23	179	202	179	202	0.96
6	6	0.016	1.3	10.3	0.2	2	23	217	238	217	238	0.94

Coding Sequence: ATGGATAAGTGTGGAATATGTTTAAAACATGCAGTTCAACTGTTCGAAACTGGCAAGGATGGTGTGTATGCCTGCTTTAAGTGTCAGCCTCTGGTGCCTGAGATATCTATTGGAGAGAACAATTCAGACCAACAAGAGGCACACTCCTCCAACAGTGAAGAgGAGAACGGTGAGCCCTCATTGTACTGTGGTTTATGCCACAAATCATTCCAGAAAAATGTTCAGCTGCAGAACCACTTGCGCAACCACCGTGCTGAGAGAAGATTTGTCTGCACATATTGCAATaaagCATTCTCTCAATCCAACAACTTGAGAGCTCACCTCCGCATCCACACCAATGAGCGACCTTTCAAGTGCTCCGAGTGTGGAAAAGCGTTCACACAGGTGACAAATCTGAACAACCATGTTCGCCTGCACACTGGAGAGAGACCATTCGTGTGCCCCGAGCCTGGCTGCGACAAGGCATATGCGCAGGTGACGAATCTGAACCAGCACCGCAAGCGCCACCTGACGGGGCGGCCCGTCGAGACCACGTACGACTGCACCGTGTGCGGAGAGCAGTTCCAGCAGCGGAACCACATGTACAACCACCGgcGTGAGGTGCACGCGGACGTGAAGAGTCCCTCGCGCAGTCCCAACCAGCGGCGCGTGTGCGTCATCTGCGAACTCAACTTCCCCAACGAGCGCCTGCTGCAGCAACACGTGCACGAACACGTCGCCGCCGGGGACACGCAGCCGCACGACGATGACGACAAGCGCGTGTACCCGTGCGTGTTCTCGACGTGCAGCTGCCTGTTCTCGTCGCCGCGCGAGCACACGGAGCACCTGCTGCGCGCGCACCAGCTGCGCGTGCTCACGCACCGCCACGCGCCGCCGCACCACGCGCCGCCCAAGCGCGGGCGCCCGCCCAAGATATTGAAGGAAGACCCATTGGAGCCGAAGGAAAATATGCAATATCATGAGgTGACCATTATCAAACACCCGCAGCCGCAGTACTTGCCCAAGCTGAAGGTGCAGAGTTTGTTCCAGTGA
Protein Sequence: MDKCGICLKHAVQLFETGKDGVYACFKCQPLVPEISIGENNSDQQEAHSSNSEEENGEPSLYCGLCHKSFQKNVQLQNHLRNHRAERRFVCTYCNKAFSQSNNLRAHLRIHTNERPFKCSECGKAFTQVTNLNNHVRLHTGERPFVCPEPGCDKAYAQVTNLNQHRKRHLTGRPVETTYDCTVCGEQFQQRNHMYNHRREVHADVKSPSRSPNQRRVCVICELNFPNERLLQQHVHEHVAAGDTQPHDDDDKRVYPCVFSTCSCLFSSPREHTEHLLRAHQLRVLTHRHAPPHHAPPKRGRPPKILKEDPLEPKENMQYHEVTIIKHPQPQYLPKLKVQSLFQ

Sequence clustering based on sequence similarity using MMseqs2