Dtri047988.1
Basic Information
- Insect
- Dasysyrphus tricinctus
- Gene Symbol
- Runx1
- Assembly
- GCA_963921185.1
- Location
- OY992532.1:88507865-88508416[-]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 2.1e-53 3.4e-49 167.8 0.0 3 96 83 176 81 183 0.96
Sequence Information
- Coding Sequence
- ATGCATCTAACGACGACACCAAACGTCACAAATACCAATACATCAAACAACAGCTCCAACAATGCAACAACTGGCACGAGTAATACAACAAATTCAACTACCGGAACTGGatcgaataataataataacactaATACAAATGGCACcaatggcaacactgaaaatACGCCGCCCACAGCAGCGCAACTGCTCAATGAAGCCTATACAAAAATGACATCTGATATATTGGCGGAAAGGACGCTAGGTGATTTTCTAACAGAACATCCGGGTGAATTGATCCGAACCGGAAGTCCGCTTTTGGTTTGTACAGTGCTGCCACCACACTGGCGATCGAATAAAACTCTGCCTGTTGCATTTAAAGTTGTTTCGTTGGGTGATATTGGCGATGGTACAATGGTAACTGTACGAGCGGGTAACGATGAGAATTATTGTGCTGAATTGAGGAATTGTACGGCCGTGATGAAGAATCAAGTGGCGAAATTCAATGATCTGAGATTTGTGGGGCGAAGTGGTCGAGGTAAGTCACATTGCAAGTATTCTACaatccaataa
- Protein Sequence
- MHLTTTPNVTNTNTSNNSSNNATTGTSNTTNSTTGTGSNNNNNTNTNGTNGNTENTPPTAAQLLNEAYTKMTSDILAERTLGDFLTEHPGELIRTGSPLLVCTVLPPHWRSNKTLPVAFKVVSLGDIGDGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSHCKYSTIQ
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00310784;
- 90% Identity
- iTF_00893636; iTF_01253316; iTF_01522341; iTF_01520747; iTF_01396263; iTF_00665409; iTF_01044513; iTF_00309995; iTF_01223164; iTF_00389396; iTF_00240438; iTF_01211675; iTF_00426126; iTF_00334743; iTF_00310784; iTF_00976224; iTF_00974410; iTF_00991537;
- 80% Identity
- -