Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.29 46 6.4 0.4 1 23 118 141 118 141 0.96

2 6 0.088 14 8.1 0.1 3 20 149 166 148 168 0.92

3 6 0.00013 0.02 17.0 0.1 2 23 181 203 180 203 0.94

4 6 4.5e-07 7.1e-05 24.7 0.7 1 23 209 232 209 232 0.98

5 6 2.3e-05 0.0036 19.3 0.5 3 23 243 263 242 263 0.98

6 6 0.00024 0.037 16.1 0.1 1 23 269 292 269 293 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.29	46	6.4	0.4	1	23	118	141	118	141	0.96
2	6	0.088	14	8.1	0.1	3	20	149	166	148	168	0.92
3	6	0.00013	0.02	17.0	0.1	2	23	181	203	180	203	0.94
4	6	4.5e-07	7.1e-05	24.7	0.7	1	23	209	232	209	232	0.98
5	6	2.3e-05	0.0036	19.3	0.5	3	23	243	263	242	263	0.98
6	6	0.00024	0.037	16.1	0.1	1	23	269	292	269	293	0.94

Coding Sequence: atgcttcaacaaGCAAGTGAAATTTCCGCAGTATCTGTCACATCAGCGTCCCAGCAAAACCCACCGGTGAGCATACAAAATCACGTCGAAGAAATTAGAAAATTGCACGACGAGATCACCGAACTGAAGAAGTCATACTGCCATAAGAACCACGACCGCTCGCGCACGCCACCGCCGCGACACCACAGGCGCAACTCGTACCGAGCGCGTTCGACGTCACGCCTCCGCTCTGGTTCAACTACACCGTCAACgcattcaattttaacaaagcagGGAAGACGGAAAACTAAAGGAGGCGTGGTTCTATCTTCCTATACAATATTCCTGGTCAAGAGAAAACAGCACTCCCCCTTCGAATGCAAGCCTTGCAACAAGCGCTGGGCCCGCTACAGCGGGCTCTGGCTGCACAACAAGACGTCGCACGGCTCGCACAAAGCCGCGTACTGCGTAGAGTGTGACAAGCAGTACCGCGACGTGTACCGCTACCGGTGGCACCTCGCTAACAGCTCCAAGCACTCGCAGCATAAGAAACATAGGATCCCCTGCCCTGGCTGTGACAAGATCTTCTCAAAGAAGATCTATATGAAGGACCACTACAACCTAGTGCATCTCAAGTTTTACAAGTATCGATGCGAACAATGCGATAAGAACTTCATTCGTAACGCTGACCTGGTGAAGCACACTCGTCGCGTCCACGAGGGTATACTACCGCTCAAGAACAAGATATGTTACATATGCGGCAGAGCATTTTCTaccAACAAAATACTAACCAACCACTTACGAACACACACAGGAGAGAAACCCTTTGCCTGTTCTATATGTAACGCGCGCTTCGCACAGAGTACCGCGTTATCTGCACATGCAAGAGCTATACATCATACTATACAGAAATAG
Protein Sequence: MLQQASEISAVSVTSASQQNPPVSIQNHVEEIRKLHDEITELKKSYCHKNHDRSRTPPPRHHRRNSYRARSTSRLRSGSTTPSTHSILTKQGRRKTKGGVVLSSYTIFLVKRKQHSPFECKPCNKRWARYSGLWLHNKTSHGSHKAAYCVECDKQYRDVYRYRWHLANSSKHSQHKKHRIPCPGCDKIFSKKIYMKDHYNLVHLKFYKYRCEQCDKNFIRNADLVKHTRRVHEGILPLKNKICYICGRAFSTNKILTNHLRTHTGEKPFACSICNARFAQSTALSAHARAIHHTIQK

Sequence clustering based on sequence similarity using MMseqs2