Basic Information

Gene Symbol
-
Assembly
GCA_949768715.1
Location
OX458320.1:24447988-24449328[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 0.0011 0.075 14.6 3.0 5 23 217 235 214 235 0.94
2 4 2.7e-07 1.8e-05 26.0 4.1 1 23 241 263 241 263 0.98
3 4 2.8 1.8e+02 4.0 6.9 1 13 267 279 267 295 0.77
4 4 0.0024 0.16 13.6 0.1 1 20 301 320 301 322 0.94

Sequence Information

Coding Sequence
ATGGTTCACTGTGCTGTTTTTGGTTGCGGTAACAACAACAGCAAAAACTTGAAACGCAACAAAACGGTTAACACCACGAACACTGCCAGAataaattacttttgtttCCCTGCGGATGAACTATTTCGTCAACAATGGATTGCACGGTGCTGTCGAaagaataaattcaattctCGTTATGCAAGGATCTGTTCGGAACACTTTAGAAATGAAGATTTCCTCATGTGTTACAATAGTGAAATATTAGGATATACTCCAGCATATCGCAGACTTAAGTCAGGAGCAATTCCGCAGCTAAAATTACCCaaaaaagataataatttgagAAAAATGGATGGTCTTGATGCTCTCAATGCACTTGAAATTAAAGTAGAACAAGAAGAACTTATAATTAAAGATGAACCGCAAGAAGTTGTGAAAGAATGTTGGTCATTTGAATATGTCAAGTTGGTAACAGATCCTCTTGCCACAAATACAGAGatcaaaCTAGAACCTTCAATATGTGGTGCTGCAAATTTAGATAGCATCCCTGAACAGGGGGTTACGTCAAAATTGCAAACCTATCTCAATTCCAAATTACGATATAAAGTAAAAGATATTGCTGGCAAAATACACATGGTGACTGATAAGAAACCTTACAAACGTCAACATTGCGACAAAAGTTTTACTCAAAACTTCACACTCAAACGGCACAATTCAATTCATGAGGACAGCAAAGCTTTTAATTGCAAACAGTGTGGCAGAAGCTTTAagcaaaagaaatatctcaaaCAACACATGTTAACTCATACAAGGCCTTTCAAATGCCAACGGTGCGACAAAGACTTTACTCGAAATTGGGCCACGGCGTCAAAAGACAACCTGAAACAGCACAAGTTGCTTCATGAGAACAAGAAACCTTTTACTTGCCAACAGTGCGGCAAAGGTTTTGTTGCAAAAGTAGGTCTCAAACTGCACGTCTTACaaggcacatgttga
Protein Sequence
MVHCAVFGCGNNNSKNLKRNKTVNTTNTARINYFCFPADELFRQQWIARCCRKNKFNSRYARICSEHFRNEDFLMCYNSEILGYTPAYRRLKSGAIPQLKLPKKDNNLRKMDGLDALNALEIKVEQEELIIKDEPQEVVKECWSFEYVKLVTDPLATNTEIKLEPSICGAANLDSIPEQGVTSKLQTYLNSKLRYKVKDIAGKIHMVTDKKPYKRQHCDKSFTQNFTLKRHNSIHEDSKAFNCKQCGRSFKQKKYLKQHMLTHTRPFKCQRCDKDFTRNWATASKDNLKQHKLLHENKKPFTCQQCGKGFVAKVGLKLHVLQGTC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00422620;
90% Identity
iTF_00422620;
80% Identity
iTF_00422620;