Dcer002955.1
Basic Information
- Insect
- Dascillus cervinus
- Gene Symbol
- -
- Assembly
- GCA_949768715.1
- Location
- OX458316.1:17881132-17884067[-]
Transcription Factor Domain
- TF Family
- HSF
- Domain
- HSF_DNA-bind domain
- PFAM
- PF00447
- TF Group
- Helix-turn-helix
- Description
- Heat shock factor (HSF) is a transcriptional activator of heat shock genes [1, 4]: it binds specifically to heat shock promoter elements, which are palindromic sequences rich with repetitive purine and pyrimidine motifs [1]. Under normal conditions, HSF is a homo-trimeric cytoplasmic protein, but heat shock activation results in relocalisation to the nucleus [2]. Each HSF monomer contains one C-terminal and three N-terminal leucine zipper repeats [3]. Point mutations in these regions result in disruption of cellular localisation, rendering the protein constitutively nuclear [2]. Two sequences flanking the N-terminal zippers fit the consensus of a bi- partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus [3]. The DNA-binding component of HSF lies to the N terminus of the first NLS region, and is referred to as the HSF domain.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 8 0.01 2e+02 3.7 0.0 8 49 30 67 23 76 0.78 2 8 0.0044 88 4.8 0.0 8 49 118 155 111 165 0.79 3 8 0.011 2.1e+02 3.6 0.0 14 48 214 246 200 251 0.77 4 8 0.0043 85 4.9 0.0 8 49 298 335 290 345 0.79 5 8 0.0045 90 4.8 0.0 14 49 394 427 380 437 0.79 6 8 0.008 1.6e+02 4.0 0.1 8 49 478 515 470 561 0.83 7 8 0.0041 81 4.9 0.1 14 49 574 607 560 650 0.84 8 8 0.0049 97 4.7 0.0 14 48 666 698 652 703 0.77
Sequence Information
- Coding Sequence
- ATGATTTTAGATCCACGACAACAGCTTGCCGCCGCATCGGCGCGGCTGAGCGGTGGTTACCGACTCTGGCAGTTTCAGCTTGAGAAACTGCTGGAGCCGGGAACTGATTACTTAGCGTGGTCGAGCGACAATCTGCACTTCAACATAATCGACCGGAACGAACTGGCGAGGCAGTGGGGCATGTTCAATAACAAGAACATGACCCCGGTGAAAATCGCTAGATCCCTAcgTGCACTATTTCgagacattcataaaatatggtcGTTTTTTACAGATCCACGACAACAGCTTGCCGCCGCATCGGCGCGGCTGAGCGGTGGTTACCGACTCTGGCAGTTTCAGCTTGAGAAACTGCTGGAGCCGGGAACTGATTACTTAGCGTGGTCGAGCGACAATCTGCACTTCCACATAATCGACCGGAACGAACTGGCGAGGCAGTGGGGCATGTTCAATAACAAGAACATGACCCCGGTGAAAATCGCTAGATCCCTAcgTGCACTATTTCgagacattcataaaatatggtcGTTTTTTACAGATCCACGACAACAGCTCGCCGCTGCATCCGAGCGGCTGAGCCGGTGGAGCCACCATGGTTACCGAATCTGGCAGTTTCTGCTTGAGAAACTGCTGGAGCCGGGAACTGATTACTTAGCGTGGTCGAGCGACAATCTGCACTTCAACATAATCGACCGGAACGAACTGGCGAGGCAGTGGGGCATGTTCAATAACAAGAACATGACCCCGGTGAAAATCGCTAGATCCCTAcgTGCACTATTTCgagacattcataaaatatggtcGTTTTTTACAGATCCACGACAACAGCTTGCCGCCGCATCGGCGCGGCTGAGCGGTGGTTACCGACTCTGGCAGTTTCAGCTTGAGAAACTGCTGGAGCCGGGAACTGATTACTTAGCGTGGTCGAGCGACAATCTGCACTTCCACATAATCGACCGGAACGAACTGGCGAGGCAGTGGGGCATGTTCAATAACAAGAACATGACCCCGGTGAAAATCGCTAGATCCCTAcgTGCACTATTTCgagacattcataaaatatggtcGTTTTTTACAGATCCACGACAACAGCTCGCCGCTGCATCCGAGCGGCTGAGCCGGTGGAGCCACCATGGTTACCGAATCTGGCAGTTTCTGCTTGAGAAACTGCTGGAGCCGGGAACTGATTACTTAGCGTGGTCGAGCGACAATCTGCACTTCCACATAATCGACCGGAACGAACTGGCGAGGCAGTGGGGCATGTTCAATAACAAGAACATGACCCCGGTGAAAATCGCTAGATCCCTAcgTGCACTATTTCGagatattcataaaatatggtcGTTTTTTACAGATCCACGACAACAGCTTGCCGCCGCATCGGCGCGGCTGAGCGGTGGTTACCGACTCTGGCAGTTTCAGCTTGAGAAACTGCTGGAGCCGGGAACTGATTACTTAGCGTGGTCGAGCGACAATCTGCACTTCAACATAATCGACCGGAACGAACTGGCGAGGCAGTGGGGCATGTTCAATAACAAGAACATGACCCCGGTGAAAATCGCTAGATCCCTAcgTGCACTATTTCgagacattcataaaatatggtcGTTTTTTACAGATCCACGACAACAGCTTGCCGCTGCATCCGAGCGGCTGAGCCGGTGGAGCCACCATGGTTACCGAATCTGGCAGTTTCTGCTTGAGAAACTGCTGGAGCCGGGAACTGATTACTTAGCGTGGTCGAGCGACAATCTGCACTTCCACATAATCGACCGGAACGAACTGGCGAGGCAGTGGGGCATGTTCAATAACAAGAACATGACCCCGGTGAAAATCGCTAGATCCCTAcgTGCACTATTTCgagacattcataaaatatggtcGTTTTTTACAGATCCACGACAACAGCTTGCCGCTGCATCCGAGCGGCTGAGCCGGTGGAGCCACCATGGTTACCGAATCTGGCAGTTTCTGCTTGAGAAACTGCTGGAGCCGGGAACTGATTACTTAGCGTGGTCGAGCGACAATCTGCACTTCCACATAATCGACCGGAACGAACTGGCGAGGCAGTGGGGCATGTTCAATAACAAGAACATGACCCCGGTGAAAATCGCTAGATCCCTAcgATCCACGACAACAGCTTGCCGCTGCATCCGAGCGGCTGAGCCGGAGGAGCCACCATGGTTACCGGCTCTGGCAGTTTCTGCTTCAGAAACTGCTAGAGCCGGGAACCCTATACATCGCCTGGTCGAACGACAACCTCGACTTTCATTTACTCGACCGCAATGA
- Protein Sequence
- MILDPRQQLAAASARLSGGYRLWQFQLEKLLEPGTDYLAWSSDNLHFNIIDRNELARQWGMFNNKNMTPVKIARSLRALFRDIHKIWSFFTDPRQQLAAASARLSGGYRLWQFQLEKLLEPGTDYLAWSSDNLHFHIIDRNELARQWGMFNNKNMTPVKIARSLRALFRDIHKIWSFFTDPRQQLAAASERLSRWSHHGYRIWQFLLEKLLEPGTDYLAWSSDNLHFNIIDRNELARQWGMFNNKNMTPVKIARSLRALFRDIHKIWSFFTDPRQQLAAASARLSGGYRLWQFQLEKLLEPGTDYLAWSSDNLHFHIIDRNELARQWGMFNNKNMTPVKIARSLRALFRDIHKIWSFFTDPRQQLAAASERLSRWSHHGYRIWQFLLEKLLEPGTDYLAWSSDNLHFHIIDRNELARQWGMFNNKNMTPVKIARSLRALFRDIHKIWSFFTDPRQQLAAASARLSGGYRLWQFQLEKLLEPGTDYLAWSSDNLHFNIIDRNELARQWGMFNNKNMTPVKIARSLRALFRDIHKIWSFFTDPRQQLAAASERLSRWSHHGYRIWQFLLEKLLEPGTDYLAWSSDNLHFHIIDRNELARQWGMFNNKNMTPVKIARSLRALFRDIHKIWSFFTDPRQQLAAASERLSRWSHHGYRIWQFLLEKLLEPGTDYLAWSSDNLHFHIIDRNELARQWGMFNNKNMTPVKIARSLRSTTTACRCIRAAEPEEPPWLPALAVSASETARAGNPIHRLVERQPRLSFTRPQ
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00421988;
- 90% Identity
- iTF_00421988;
- 80% Identity
- iTF_00421988;