Basic Information

Gene Symbol
ZIC4
Assembly
GCA_004959915.1
Location
RPCZ01000037.1:1705957-1718458[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.00056 0.04 14.6 5.2 1 23 264 286 264 286 0.98
2 9 0.31 22 5.9 0.1 1 23 293 315 293 315 0.96
3 9 0.14 10 7.0 0.3 1 23 319 342 319 342 0.96
4 9 0.11 7.9 7.4 6.1 1 23 349 371 349 372 0.94
5 9 1.8e-05 0.0013 19.3 0.2 2 21 378 397 378 402 0.93
6 9 1.7e-05 0.0012 19.4 0.2 1 23 452 475 452 475 0.96
7 9 0.00024 0.018 15.7 0.9 1 23 481 504 481 504 0.97
8 9 0.00048 0.035 14.8 2.5 1 23 513 535 513 535 0.97
9 9 1.8e-05 0.0013 19.3 0.2 1 23 541 564 541 564 0.96

Sequence Information

Coding Sequence
ATGGAGACTCATCATAGCTTAGTTGAGATCGAATATAAACCGGAATTAGACGCGCCTAAAACTATATGCCGCTGTTGTCTTTCAACCGACCGTCGGGTCGTGAAAATTGAGAATTATCGTGAACTTTTCGTTGAATTGGCTGATATAATAGTGTCCGATTCCGATGGTCTCCCTCAATGGCTCTGCTGGGAATGCAGCTGTCTACTGATGAAGAGTGTACGCTTCAAGCAAAAAGTATTGAAAGCTCATCTTACACTATACAACTATCATAGTCGATGTGCTCCGTTCCCTATAGATGGCCAGGATCCTGAACTGACTAAGTATGCTAACCCACAACTGAGCAGCTCGGCCACATTAGTCATAGATAATGTCAAGACTAAAACAGGATACCATAAACATGAGAAAATCCACTTCATGCCCCCGTCGGATGAAACTCACTTTCTCGATGAAGAAGTTCCTCTTAAACTGGAGACTGAAGATGATGTACCACTACAGGAGATACGTGAAAATAAGTTGAAAGACATGGGACTAGATGGCTTCATAACAGAATCTACTCAAGAGAAGAAAGAAAAGaccaaaaaagttaaaaagaaaGTTAAGATAAGAGTTACGGATAATTTTAAGACGGAGAATGAGTTAGATGAACCACAAGAGGCTAAGACACCAAAGAAACGAAATCTACGGAGAACTATAGACATAGATGAGAACAAGATAAGAGTCATCACACTCGACCCGGCTGAACAACTTAGGCAGAGACAGGCTGAGAACGAAGCGACGCTGAAATTTCCCTTCCAATGCCATCTTTGCTTCAAAGGTTTCAACTATGAAGAGAAGCTCAAGAATCACATGTTCAAACACAGTCcgGCTCGCGGCAGCTACAAGTGTGAGGTGTGCAGCATGTACCTGCCCACACCATACTCTGCCTCTGTGCACGGACTCACTCACACGATGAGGTATGAGTGTGTGCAGTGTGGTAGACGGATGACCGACAGGCTGGCTATAGTCAATCATTACAGATCTCAACACGAGGGTGTGCTCTCGGTCTACACTTGTCACATATGTGGGAAAGTATCAAAtAATGACAAGACTCACCGCGGCCACATGAGGAATCATCACTCTGGCTCGCGGGCTGTCTGCAGAGAGTGTGGGAAGAGCTTCGTTAATAATGACTCACTGGCCGAGCACATGCTGAACCAGATAAGACACCACCTCGTGAAGCACAGCGACCACAAGGACTTCTACTGTGTGGAGTGTGACGTGAGgagaGGAACAAGTAATAATCGGAAGGAGCAAGGTCTGGGGAGTACGGAGGATGAGAGAACAACTAAACATAAAGACAAGAAAAGTCTCAAGTTCGCGTGCTCATTATGCCCGAAACGTTTTGACACCGCCGCCCTACTAACAACACACACTCGGGTCCAACACGAAGGTTCAAGACCACATCGCTGCGAGGAGTGTGGGGCTTCGCTGGCGACCCGCGCGTCCCTACACAAGCACGCGCGCTCCGTGCACCGGGGACTTCGCCCCCCGCCCTCACATATATGCCACGCGTGCGGAAAATTGTTCCGAGCGAGATCTACATTAGTGAATCATGTTAGAACACATACTGGAGAGAAGCCCTACCCCTGTGAGGATTGTGGGCGGAGGTTCGCGCAACGAACGGCCATGAGGACGCATGTGAAGCTGGTACATATGAAACAGAGAGGGAGGGAGGATTAG
Protein Sequence
METHHSLVEIEYKPELDAPKTICRCCLSTDRRVVKIENYRELFVELADIIVSDSDGLPQWLCWECSCLLMKSVRFKQKVLKAHLTLYNYHSRCAPFPIDGQDPELTKYANPQLSSSATLVIDNVKTKTGYHKHEKIHFMPPSDETHFLDEEVPLKLETEDDVPLQEIRENKLKDMGLDGFITESTQEKKEKTKKVKKKVKIRVTDNFKTENELDEPQEAKTPKKRNLRRTIDIDENKIRVITLDPAEQLRQRQAENEATLKFPFQCHLCFKGFNYEEKLKNHMFKHSPARGSYKCEVCSMYLPTPYSASVHGLTHTMRYECVQCGRRMTDRLAIVNHYRSQHEGVLSVYTCHICGKVSNNDKTHRGHMRNHHSGSRAVCRECGKSFVNNDSLAEHMLNQIRHHLVKHSDHKDFYCVECDVRRGTSNNRKEQGLGSTEDERTTKHKDKKSLKFACSLCPKRFDTAALLTTHTRVQHEGSRPHRCEECGASLATRASLHKHARSVHRGLRPPPSHICHACGKLFRARSTLVNHVRTHTGEKPYPCEDCGRRFAQRTAMRTHVKLVHMKQRGRED

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00421570;
90% Identity
-
80% Identity
-