Basic Information

Gene Symbol
-
Assembly
GCA_947568885.1
Location
OX387699.1:6503172-6506059[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 19 9.9e-05 0.0061 17.5 4.3 1 23 37 60 37 60 0.95
2 19 0.47 29 6.0 0.6 3 23 88 108 86 108 0.96
3 19 0.1 6.4 8.0 1.0 2 23 131 153 130 153 0.93
4 19 0.0025 0.15 13.1 0.1 1 23 159 181 159 181 0.95
5 19 5.4e-05 0.0034 18.4 2.0 1 23 189 212 189 212 0.94
6 19 0.018 1.1 10.4 0.3 1 23 217 240 217 240 0.92
7 19 0.0014 0.088 13.9 1.6 1 23 247 270 247 270 0.93
8 19 0.00047 0.029 15.4 0.8 3 23 278 298 276 298 0.94
9 19 8.9e-05 0.0055 17.7 3.9 1 23 304 326 304 326 0.98
10 19 1.2e-08 7.7e-07 29.8 0.6 1 23 332 354 332 354 0.99
11 19 8.9e-06 0.00055 20.8 3.3 1 23 399 421 399 421 0.98
12 19 5.3 3.3e+02 2.7 1.1 2 23 448 469 447 469 0.91
13 19 0.041 2.5 9.3 0.5 2 23 491 513 490 513 0.96
14 19 0.0069 0.43 11.7 1.1 3 23 521 541 520 542 0.94
15 19 0.2 12 7.1 2.6 1 23 547 570 547 570 0.84
16 19 0.59 37 5.6 5.6 1 23 575 598 575 598 0.95
17 19 6.4e-05 0.0039 18.1 1.5 1 23 603 626 603 626 0.97
18 19 0.0013 0.081 14.0 0.2 1 23 632 654 632 654 0.97
19 19 0.01 0.63 11.2 0.1 1 23 662 684 662 684 0.98

Sequence Information

Coding Sequence
ATGGAGAGCACAGACCTGGGTGCCCGCAAACGGGAGGAACTGACCAAACTGCTCACCATTATGATAGAGAACTCCACCGTCATACCCTTCAAATGGCACGCCAACGGTTTCCTGTGCTTCTACTGTGGCTGCCCCTTCACCGACTCTTCAGCTCTCAAGCACCACACCAAGACTGAACACGAGAACGCCAAACTCAAAACTATCTTGAGAACCACTGTTGCGAAAAGCAGGAGCATTAAACTCGATGTGTCAGAGCTAGCTTGCAAGAAATGCAGCGAACCTATGCGCAGCTTACAACAGTTCTTCATCCATATTAAACAACATGGTTTTACAATAAATGAAGAGGCTTCACATTGCTGCTATCCATTCATTCTTACTGATAATGATATGTCCTGTCTTGAATGTGGGATGTCTTTTAGATTTTTCGGCCCTCTTTTAATTCACACACACAAATATCACACCAAAACTGAGCCGTTCCTTTGTGAAATATGCGGGCAAGGATTTATAGCTAAAGCGAACGTGGAAAGCCATCGGAAAATACACAACAAAAAGTCCAATTGCAATTATAACTGCAAAGAGTGTGATAAAACATTCCCTTCACAGTACAAACTCAATTATCATTTCGAAAAAGTCCATACTCCAGCCAAATTCAAGTGTCCTAAATGTCCAGAAGTTCTAGGCAGCCAATACTTGAAGAAACGTCATTTGGCTTTCGTACATGATGTGAAAAGCGCGCAGTTTAAATGTGACGAGTGTCAGAAGATTTTCTCGTTGAAAAACAAGTTGCTTCAGCATAAATCACAGGTGCATTTGAAAGAAAGAAACATTGCCTGCGAAATTTGTGGACACAAAGTGTTCAGTAAAGATCTCTTGAAGCGGCATATGGTGAAGCATGATGATTCTAGACCGTTTGAGTGTGAATTCTGCAAGAAAACTTTTCAAAGAAAGAAGACCTTGGAGTACCACAGGAGGATACATACGAACGACAAGAGGTATCAGTGCAAGGAGTGTGGGAGGTCGTTCGTGCAGTGGACGAGCCTCAAGCTGCATATGAGAGTGCATTATTCCAATCCAAAGAAGCACGACCTCCGCGTCCCAACGCAAATCGAATGGCAAAAGGCAGCCGCCCGTCGCTACGTCCACTCCGTCCTAACCCACTCCTCCCTCCTCCCCTTCCGTTGGCGCGGCAACCGCTACATCTGCTTCTACTGCCACTACACCTTCACCGAGGCCTCCAGCTTAAGGGCACACACCAGGACACACCAAAACCTGGCCATTATGAAGCATTTAACACAAACTAGGGACTTCGCTCCTATAAAGGTAGACATCAGAGAAACTTTAAAATGCCTCAAGTGTAAACACGAGGAAGATAGCTTAGAAGGACTAATTACGCATCTTAAAACACACAAACTGATAGGAGATATAGACCAGGAGTGTTTCTTGCCTTTCAAGCTAGCTGATAATCAGATATCTTGCTTGAAATGTGCTAAATCTTATCAGTCTTTCGGCATGCTATACTCTCATATGAATAAAGTTCATTTGGAAGGCACTAAGCGCATTTGCGAGGCGTGCGGTGAAAGTTTTTTCTCAGATTTCAGTTTAAGAAAGCATGTGCAGTCGCATCACTCTAATTCCGACTTCAAATGTAGCCATTGCAACGAGAAATTTAAGTTGGACGCGAATAGGATTAGCCACGAATATAAAGAGCATAACATCAAGTCTTTCAAATGCTACAAATGCGACGAAATGTTCGGTTCGCATTACTTAAGACGTCTGCACTTGCATAGTACTCATATGAAGATGGAATTCACGTGTCAGGAGTGTTCTAAAACCTTTCTAAACAAGTCTTTACTGAATCGACACGTGAATAGGGTTCATTTGAAGGAGAAAAACTTCACGTGCCCGGTTTGTGGGGACAAGTTCTTTGATCTGGGCACTTTGAACGTGCATGCGAAGAAGCATTCGTATAGCCCGCAGAAGAGTTTTCAATGTAGGGTTTGCTTGTTGGTTTTCGGTGGGAAGATGGAGCTGAATGATCATATGGTGACTCATGCGGGGCAGTCGCTGTCATTGAAGTAA
Protein Sequence
MESTDLGARKREELTKLLTIMIENSTVIPFKWHANGFLCFYCGCPFTDSSALKHHTKTEHENAKLKTILRTTVAKSRSIKLDVSELACKKCSEPMRSLQQFFIHIKQHGFTINEEASHCCYPFILTDNDMSCLECGMSFRFFGPLLIHTHKYHTKTEPFLCEICGQGFIAKANVESHRKIHNKKSNCNYNCKECDKTFPSQYKLNYHFEKVHTPAKFKCPKCPEVLGSQYLKKRHLAFVHDVKSAQFKCDECQKIFSLKNKLLQHKSQVHLKERNIACEICGHKVFSKDLLKRHMVKHDDSRPFECEFCKKTFQRKKTLEYHRRIHTNDKRYQCKECGRSFVQWTSLKLHMRVHYSNPKKHDLRVPTQIEWQKAAARRYVHSVLTHSSLLPFRWRGNRYICFYCHYTFTEASSLRAHTRTHQNLAIMKHLTQTRDFAPIKVDIRETLKCLKCKHEEDSLEGLITHLKTHKLIGDIDQECFLPFKLADNQISCLKCAKSYQSFGMLYSHMNKVHLEGTKRICEACGESFFSDFSLRKHVQSHHSNSDFKCSHCNEKFKLDANRISHEYKEHNIKSFKCYKCDEMFGSHYLRRLHLHSTHMKMEFTCQECSKTFLNKSLLNRHVNRVHLKEKNFTCPVCGDKFFDLGTLNVHAKKHSYSPQKSFQCRVCLLVFGGKMELNDHMVTHAGQSLSLK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00411708;
90% Identity
iTF_00411708;
80% Identity
-